Migraine is a neurological disease, which affects women three times more than men, and is classified by the World Health Organization as the 6th most disabling disorder in the world. Migraine is classically characterized by throbbing, unilateral pain often accompanied by nausea, vomiting and sensitivity to light, sounds and sensory stimuli. Additionally, prodromes such as fatigue and irritability may occur up to 48 hours before the headache, and postdromes such as malaise and fatigue may last up to 24 hours afterward. Thus, migraine appears to be more than a simple headache and affects multiple brain areas involved in the regulation of autonomic, affective, cognitive and sensory functions.

Our goal is to better understand the mechanisms underlying the appearance of migraine attacks as well as the chronicization of this pathology. For this we study the role of different factors on the occurrence of migraine attacks, such as the influence of the female hormonal cycle, the importance of diet with an interest in tryptophan, inflammatory mechanisms, as well as the relationships between activation of the trigeminal system which integrates facial pain and external stimulations (light, sound, touch, etc.) which are both symptoms of migraine and triggering factors. Finally, with a therapeutic objective, we are developing new non-pharmacological treatment protocols with transcranial magnetic (rTMS) and electrical stimulation (tDCS), while studying their mechanisms of action on brain activity.