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Molecular and Cellular Pain Modulators Axis

Field of research

The “Microbial Metabolites and Chronic Pain” research axis explores the interactions between metabolites derived from the intestinal microbiota and the nervous system in the context of chronic pain. We are studying the role of the intestinal microbiota and its metabolites in the mechanisms of pain chronicization, in particular the involvement of the AhR/IL-22 pathway. We are also interested in the impact of microbial and/or tissue metabolites on the disturbances in “well-being” associated with chronic pain. Finally, we characterize new probiotics with anti-hyperalgesic potential, by evaluating their neuromodulatory power.

Team leaders

Members

Publication HAL

Journal articles

2023

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Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, et al.. A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience, 2023, 26 (4), pp.673-681. ⟨10.1038/s41593-023-01286-8⟩. ⟨hal-04268925⟩
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https://hal.science/hal-04268925/file/Grandjean-Nature-Neuroscience-2023.pdf


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Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha Ahmed, et al.. Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases. Biomolecules, 2023, 13 (2), pp.342. ⟨10.3390/biom13020342⟩. ⟨hal-04010965⟩
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https://hal.science/hal-04010965/file/2023_Khoury%20et%20al_Biomolecules.pdf


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Thibault Léger, Aurélien Brun, Kassandra Lanchais, Jean-Paul Rigaudière, Arnaud Briat, et al.. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sciences, 2023, 327, pp.121826. ⟨10.1016/j.lfs.2023.121826⟩. ⟨hal-04162926⟩
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Nazarine Mokhtar, Stephane Doly, Christine Courteix. Diabetic Neuropathic Pain and Serotonin: What Is New in the Last 15 Years?. Biomedicines, 2023, Pathological Mechanisms in Diabetes 2.0, 11 (7), pp.1924. ⟨10.3390/biomedicines11071924⟩. ⟨hal-04323925⟩
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https://hal.science/hal-04323925/file/Mokhtar%20et%20al.%2C%202023%20Biomedicines.pdf


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Nazarine Mokhtar, Marcin Drop, Florian Jacquot, Sylvain Lamoine, Eric Chapuy, et al.. The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats. Biomolecules, 2023, Recent Advances on 5-HT6 Receptors, 13 (2), pp.364. ⟨10.3390/biom13020364⟩. ⟨hal-04094286⟩
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https://uca.hal.science/hal-04094286/file/Mokhtar%20et%20al.%2C%202023.pdf


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2022

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K. Delanoe, F. Marchand, E. Lingueglia, Emmanuel Deval. Canaux ASIC senseurs de l’acidification, lysophosphatidylcholine et douleur chronique. Douleur et Analgésie, 2022, 35 (4), pp.231-238. ⟨10.3166/dea-2022-0238⟩. ⟨hal-04011485⟩
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Lauriane Delay, Julie Barbier, Youssef Aissouni, Alexandra Jurczak, Ludivine Boudieu, et al.. Tyrosine kinase type A–specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis. Pain, 2022, 163 (7), pp.e837-e849. ⟨10.1097/j.pain.0000000000002492⟩. ⟨hal-04316536⟩
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Amélie Démosthènes, Benoît Sion, Fabrice Giraudet, Xavier Moisset, Laurence Daulhac, et al.. In-Depth Characterization of Somatic and Orofacial Sensitive Dysfunctions and Interfering-Symptoms in a Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mouse Model. Frontiers in Neurology, 2022, 12, pp.789432. ⟨10.3389/fneur.2021.789432⟩. ⟨hal-03552469⟩
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https://uca.hal.science/hal-03552469/file/fneur-12-789432.pdf


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Cyril Goudet, Fabien Marchand. Editorial: Molecular mechanisms of nociception. Frontiers in Molecular Neuroscience, 2022, 15, pp.1025230. ⟨10.3389/fnmol.2022.1025230⟩. ⟨hal-03805607⟩
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https://hal.science/hal-03805607/file/2022%20Goudet%20%26%20Marchand%20FIMN%20Molecular%20Mechanisms%20of%20Nociception.pdf


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Alexandra Jurczak, Lauriane Delay, Julie Barbier, Nils Simon, Emerson Krock, et al.. Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3–dependent sensitization. Pain, 2022, 163 (8), pp.1542-1559. ⟨10.1097/j.pain.0000000000002543⟩. ⟨hal-04061760⟩
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https://hal.science/hal-04061760/file/Antibody_induced_pain_like_behavior_and_bone.17.pdf


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Guy Khalaf, Claudia Mattern, Mélina Begou, Odile Boespflug-Tanguy, Charbel Massaad, et al.. Mutation of Proteolipid Protein 1 Gene: From Severe Hypomyelinating Leukodystrophy to Inherited Spastic Paraplegia. Biomedicines, 2022, 10 (7), pp.1709. ⟨10.3390/biomedicines10071709⟩. ⟨hal-03798606⟩
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https://hal.science/hal-03798606/file/biomedicines-10-01709.pdf


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Maha Mabrouk, Mohamed El Ayed, Amélie Démosthènes, Youssef Aissouni, Ezzedine Aouani, et al.. Antioxidant effect of grape seed extract corrects experimental autoimmune encephalomyelitis behavioral dysfunctions, demyelination, and glial activation. Frontiers in Immunology, In press, ⟨10.3389/fimmu.2022.960355⟩. ⟨hal-03768907⟩
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https://hal.science/hal-03768907/file/fimmu-13-960355.pdf


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Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, et al.. Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity. Frontiers in Molecular Neuroscience, 2022, 15, pp.880651. ⟨10.3389/fnmol.2022.880651⟩. ⟨hal-03855415⟩
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https://hal.science/hal-03855415/file/Pidoux%20et%20al_Front%20Mol%20Neuro%202022.pdf


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Annabelle Réaux-Le-Goazigo, Benoît Beliard, Lauriane Delay, Line Rahal, Julien Claron, et al.. Ultrasound localization microscopy and functional ultrasound imaging reveal atypical features of the trigeminal ganglion vasculature. Communications Biology, 2022, ⟨10.1038/s42003-022-03273-4⟩. ⟨hal-03649783⟩
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https://hal.science/hal-03649783/file/Reaux-2022-Ultrasound%20localization%20microscopy%20and%20functional%20ultrasound%20imaging%20reveal%20atypical%20features%20of%20the%20trigeminal%20ganglion%20vasculature.pdf


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Kusumika Saha, Benoit Chevalier, Stéphane Doly, Nesrine Baatallah, Thomas Guilbert, et al.. Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites. Cellular and Molecular Life Sciences, 2022, 79 (10), pp.530. ⟨10.1007/s00018-022-04554-1⟩. ⟨hal-03783229⟩
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https://hal.science/hal-03783229/file/RevisedArticle%232CMLSTracked.pdf


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2021

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Mélina Bégou, Benoit Sion. Can chronopharmacology improve the therapeutic management of neurological diseases?. Fundamental & Clinical Pharmacology, 2021, 35 (3), pp.564-581. ⟨10.1111/fcp.12659⟩. ⟨hal-03554969⟩
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Christine Courteix, Alain Eschalier, Christophe Mallet. L’évaluation de la douleur chez l’animal de laboratoire. Douleur et Analgésie, 2021, 34 (2), pp.114-122. ⟨10.3166/dea-2021-0145⟩. ⟨hal-03418812⟩
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https://uca.hal.science/hal-03418812/file/DOULEUR_ANALG-S-20-00043.pdf


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Stéphane Doly, Pierre-Yves Martin, Christine Courteix. Récepteur 5-HT6 et mTOR. Médecine/Sciences, 2021, 37 (5), pp.547-549. ⟨10.1051/medsci/2021049⟩. ⟨hal-03229327⟩
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https://hal.science/hal-03229327/file/msc200385.pdf


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Marcin Drop, Florian Jacquot, Vittorio Canale, Séverine Chaumont-Dubel, Maria Walczak, et al.. Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide. Bioorganic Chemistry, 2021, 115, pp.105218. ⟨10.1016/j.bioorg.2021.105218⟩. ⟨hal-03324439⟩
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https://hal.science/hal-03324439/file/154-2021-BC.pdf


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A.M. Hamieh, G. Mallaret, M. Meleine, A. Lashermes, S. Roumeau, et al.. Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. Brain, Behavior, and Immunity, 2021, 93, pp.226-237. ⟨10.1016/j.bbi.2021.01.020⟩. ⟨hal-03516251⟩
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Delay Lauriane, Barbier Julie, Aissouni Youssef, Jurczak Alexandra, Boudieu Ludivine, et al.. TrkA specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis. Pain, 2021, Publish Ahead of Print, ⟨10.1097/j.pain.0000000000002492⟩. ⟨hal-04327575⟩
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Delay Lauriane, Barbier Julie, Aissouni Youssef, Jurczak Alexandra, Boudieu Ludivine, et al.. TrkA specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis. Pain, 2021, Publish Ahead of Print, ⟨10.1097/j.pain.0000000000002492⟩. ⟨hal-03426453⟩
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Vanessa Pereira, Sylvain Lamoine, Mélissa Cuménal, Stéphane Lolignier, Youssef Aissouni, et al.. Epigenetics Involvement in Oxaliplatin-Induced Potassium Channel Transcriptional Downregulation and Hypersensitivity. Molecular Neurobiology, 2021, 58 (7), pp.3575-3587. ⟨10.1007/s12035-021-02361-6⟩. ⟨hal-03511787⟩
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2020

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Jérôme Busserolles, Ismail Ben Soussia, Laetitia Pouchol, Nicolas Marie, Mathieu Meleine, et al.. TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects. British Journal of Pharmacology, 2020, 177 (20), pp.4782-4795. ⟨10.1111/bph.15243⟩. ⟨hal-03512213⟩
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https://uca.hal.science/hal-03512213/file/BPH-177-4782.pdf


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Jérôme Busserolles, Stéphane Lolignier, Nicolas Kerckhove, Célian Bertin, Nicolas Authier, et al.. Replacement of current opioid drugs focusing on MOR-related strategies. Pharmacology and Therapeutics, 2020, 210, pp.107519. ⟨10.1016/j.pharmthera.2020.107519⟩. ⟨hal-03490336⟩
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https://hal.science/hal-03490336/file/S0163725820300474.pdf


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Tanguy Chaumette, Lauriane Delay, Julie Barbier, Ludivine Boudieu, Youssef Aissouni, et al.. c-Jun/p38MAPK/ASIC3 pathways specifically activated by nerve growth factor through TrkA are crucial for mechanical allodynia development. Pain, 2020, pp.1. ⟨10.1097/j.pain.0000000000001808⟩. ⟨hal-02464551⟩
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https://hal.science/hal-02464551/file/PAIN-D-19-00901_R2.pdf


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Mélissa Cuménal, Marie Selvy, Nicolas Kerckhove, Célian Bertin, Margaux Morez, et al.. The Safety of Medications used to Treat Peripheral Neuropathic Pain, Part 2 (Opioids, Cannabinoids and Other Drugs): review of Double-Blind, Placebo-Controlled, Randomized Clinical Trials. Expert Opinion on Drug Safety, 2020, pp.1-18. ⟨10.1080/14740338.2021.1842871⟩. ⟨hal-02997543⟩
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https://uca.hal.science/hal-02997543/file/Medications_safety_2_-_EODS.pdf


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Dimitra Gkika, Stéphane Lolignier, Guillaume Grolez, Alexis Bavencoffe, Georges Shapovalov, et al.. Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity. FASEB Journal, 2020, 34 (6), pp.7483-7499. ⟨10.1096/fj.201902270R⟩. ⟨hal-03512394⟩
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https://uca.hal.science/hal-03512394/file/The%20FASEB%20Journal%20-%202020%20-%20Gkika%20-%20Testosterone%25u2010androgen%20receptor%20The%20steroid%20link%20inhibiting%20TRPM8%25u2010mediated%20cold.pdf


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Pierre-Yves Martin, Stéphane Doly, Al Mahdy Hamieh, Eric Chapuy, Vittorio Canale, et al.. mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment. Progress in Neurobiology, 2020, 193, pp.101846. ⟨10.1016/j.pneurobio.2020.101846⟩. ⟨hal-02906397⟩
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https://uca.hal.science/hal-02906397/file/Martin-Prog-Neurobiol.pdf


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Mark G H Scott, Stefano Marullo, Stéphane Doly, Kusumika Saha, Hervé Enslen, et al.. Mechanical GPCR activation by traction forces exerted on receptor N-glycans. ACS Pharmacology & Translational Science, 2020, ⟨10.1021/acsptsci.9b00106⟩. ⟨hal-02493908⟩
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https://hal.science/hal-02493908/file/ACS%20Perspective%20.pdf


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Marie Selvy, Mélissa Cuménal, Nicolas Kerckhove, Christine Courteix, Jérôme Busserolles, et al.. The safety of medications used to treat peripheral neuropathic pain, part 1 (antidepressants and antiepileptics): review of double-blind, placebo-controlled, randomized clinical trials. Expert Opinion on Drug Safety, 2020, 19 (6), pp.707-733. ⟨10.1080/14740338.2020.1764934⟩. ⟨hal-02997564⟩
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https://uca.hal.science/hal-02997564/file/Medications_safety_-_EODS.pdf


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2019

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David André Barrière, Al Mahdy Hamieh, Ricardo Magalhães, Amidou Traore, Julie Barbier, et al.. Structural and functional alterations in the retrosplenial cortex following neuropathic pain. Pain, 2019, 160 (10), pp.2241-2254. ⟨10.1097/j.pain.0000000000001610⟩. ⟨hal-04327523⟩
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Hichem Bouchenaki, Mélina Bégou, Laurent Magy, Rodolphe Hajj, Claire Demiot. Les traitements pharmacologiques des douleurs neuropathiques. Thérapie, 2019, 74 (6), pp.633-643. ⟨10.1016/j.therap.2019.04.003⟩. ⟨hal-03332441⟩
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https://hal.science/hal-03332441/file/S0040595719300691.pdf


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Ombeline Danton, Aimé Somboro, Baba Fofana, Drissa Diallo, Lassine Sidibé, et al.. Ethnopharmacological survey of plants used in the traditional treatment of pain conditions in Mali. International Journal of Herbal Medicine, 2019, 17-18, pp.100271. ⟨10.1016/j.hermed.2019.100271⟩. ⟨hal-02462026⟩
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https://hal.science/hal-02462026/file/S221080331930017X.pdf


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Zoé Virion, Stéphane Doly, Kusumika Saha, Mireille Lambert, Francois Guillonneau, et al.. Sialic acid mediated mechanical activation of β 2 adrenergic receptors by bacterial pili. Nature Communications, 2019, 10, pp.4752. ⟨10.1038/s41467-019-12685-6⟩. ⟨hal-02485670⟩
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https://hal.science/hal-02485670/file/s41467-019-12685-6.pdf


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2018

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Arnauld Belmer, Emily Quentin, Silvina L. Diaz, Bruno Guiard, Sebastian P Fernandez, et al.. Positive regulation of raphe serotonin neurons by serotonin 2B receptors. Neuropsychopharmacology, 2018, 43 (7), pp.1623-1633. ⟨10.1038/s41386-018-0013-0⟩. ⟨hal-01703916⟩
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https://hal.science/hal-01703916/file/Belmer_Text_NPP_Fig05022018.pdf


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Alexandros H Kanellopoulos, Jennifer Koenig, Honglei Huang, Martina Pyrski, Queensta Millet, et al.. Mapping protein interactions of sodium channel Na V 1.7 using epitope‐tagged gene‐targeted mice. EMBO Journal, 2018, 37 (3), pp.427 – 445. ⟨10.15252/embj.201796692⟩. ⟨hal-03512558⟩
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https://uca.hal.science/hal-03512558/file/The%20EMBO%20Journal%20-%202018%20-%20Kanellopoulos%20-%20Mapping%20protein%20interactions%20of%20sodium%20channel%20NaV1%207%20using%20epitope%25u2010tagged.pdf


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Yao Potchoo, Edem Goeh-Akue, Findibe Damorou, Stéphane Lolignier, Barima Massoka, et al.. Antihypertensive Drug Regimen for High Blood Pressure Associated with Modifiable Cardiovascular Risk Factors Among Hypertensive Patients Attending Campus Teaching Hospital of Lomé, Togo, West Africa. Journal of Pharmaceutical and Pharmacological Sciences, 2018, 3 (1), pp.1-9. ⟨10.29011/2574-7711⟩. ⟨hal-03111109⟩
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https://uca.hal.science/hal-03111109/file/a13566b472cb096ad2632f0c2dda1d2d9449.pdf


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Laura Poupon, Sylvain Lamoine, Vanessa Pereira, David Barriere, Stéphane Lolignier, et al.. Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. Neuropharmacology, 2018, 140, pp.43-61. ⟨10.1016/j.neuropharm.2018.07.026⟩. ⟨hal-02065469⟩
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https://hal.science/hal-02065469/file/Poupon_Targeting_TREK-1_CombinedAAM.pdf


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Ramin Raouf, Stéphane Lolignier, Jane Sexton, Queensta Millet, Sonia Santana-Varela, et al.. Inhibition of somatosensory mechanotransduction by annexin A6. Science Signaling, 2018, 11 (535), ⟨10.1126/scisignal.aao2060⟩. ⟨hal-03512530⟩
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2017

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Youssef Aissouni, Abderrahim El Guerrab, Al Mahdy Hamieh, Jérémy Ferrier, Maryse Chalus, et al.. Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis. Scientific Reports, 2017, 7 (1), pp.43617. ⟨10.1038/srep43617⟩. ⟨hal-04317279⟩
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https://hal.science/hal-04317279/file/srep43617.pdf


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T. Chaumette, E. Chapuy, E. Berrocoso, M. Llorca-Torralba, L. Bravo, et al.. Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. European Journal of Pain, 2017, 22 (1), pp.127-141. ⟨10.1002/ejp.1097⟩. ⟨hal-04317243⟩
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Chouki Chenaf, Eric Chapuy, Frédéric Libert, Fabien Marchand, Christine Courteix, et al.. Agomelatine: a new opportunity to reduce neuropathic pain. Preclinical evidence.. Pain, 2017, 158 (1), pp.149 – 160. ⟨10.1097/j.pain.0000000000000738⟩. ⟨hal-01659567⟩
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Stephane Doly, Emily Quentin, Raphaël Eddine, Stefania Tolu, Sebastian P Fernandez, et al.. Serotonin 2B receptors in mesoaccumbens dopamine pathway regulate cocaine responses. Journal of Neuroscience, 2017, 37 (43), pp.10372-10388. ⟨10.1523/JNEUROSCI.1354-17.2017⟩. ⟨hal-01593826⟩
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https://hal.science/hal-01593826/file/Doly_JN_final.pdf


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Amandine Dupuis, Anne-Sophie Wattiez, Jérémy Pinguet, Damien Richard, Frédéric Libert, et al.. Increasing spinal 5-HT 2A receptor responsiveness mediates anti-allodynic effect and potentiates fluoxetine efficacy in neuropathic rats. Evidence for GABA release. Pharmacological Research, 2017, 118, pp.93-103. ⟨10.1016/j.phrs.2016.09.021⟩. ⟨hal-04317276⟩
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Alexandra Jean, Laetitia Laurent, Sabira Delaunay, Stéphane Doly, Nicole Dusticier, et al.. Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress. Cell Reports, 2017, 21 (4), pp.901-909. ⟨10.1016/j.celrep.2017.10.003⟩. ⟨hal-01667516⟩
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https://hal.science/hal-01667516/file/PIIS2211124717314201.pdf


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Imane Moutkine, Emily Quentin, Bruno P. Guiard, Luc Maroteaux, Stephane Doly. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT 2C protomers. Journal of Biological Chemistry, 2017, 292 (15), pp.6352-6368. ⟨10.1074/jbc.M117.779041⟩. ⟨hal-01593841⟩
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https://hal.science/hal-01593841/file/JBCrev2_LM.pdf


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Lusliany J Rondón, Marie-Chantal Farges, N Davin, B Sion, a M Privat, et al.. L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration. European Journal of Nutrition, 2017, 57 (7), 11 p. ⟨10.1007/s00394-017-1508-x⟩. ⟨hal-01594068⟩
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Montserrat Ruiz, Mélina Bégou, Nathalie Launay, Pablo Ranea-Robles, Patrizia Bianchi, et al.. Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathology, 2017, 28 (5), pp.611-630. ⟨10.1111/bpa.12571⟩. ⟨hal-01662573⟩
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Delphine Vivier, Ismail Ben Soussia, Nuno Rodrigues, Stéphane Lolignier, Maïly Devilliers, et al.. Development of the First Two-Pore Domain Potassium Channel TWIK-Related K + Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity. Journal of Medicinal Chemistry, 2017, 60 (3), pp.1076-1088. ⟨10.1021/acs.jmedchem.6b01285⟩. ⟨hal-02390407⟩
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Anne-Sophie Wattiez, Amandine Dupuis, Anne-Marie Privat, Maryse Chalus, Eric Chapuy, et al.. Disruption of 5-HT 2A -PDZ protein interaction differently affects the analgesic efficacy of SSRI, SNRI and TCA in the treatment of traumatic neuropathic pain in rats. Neuropharmacology, 2017, 125, pp.308-318. ⟨10.1016/j.neuropharm.2017.07.034⟩. ⟨hal-04323800⟩
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2016

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Carmen Cifuentes-Diaz, Stefano Marullo, Stéphane Doly. Anatomical and ultrastructural study of PRAF2 expression in the mouse central nervous system. Brain Structure and Function, 2016, 221 (8), pp.4169-4185. ⟨10.1007/s00429-015-1159-8⟩. ⟨hal-02485729⟩
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https://hal.science/hal-02485729/file/BSF.pdf


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Stéphane Doly, Hamasseh Shirvani, Gabriel Gäta, Frank J Meye, Michel-Boris Emerit, et al.. GABA B receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper. Molecular Psychiatry, 2016, 21 (4), pp.480-490. ⟨10.1038/mp.2015.72⟩. ⟨hal-02485707⟩
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Stéphane Doly, Hamasseh Shirvani, Gabriel Gäta, Frank J Meye, Michel-Boris Emerit, et al.. GABAB receptor cell surface export is controlled by an endoplasmic reticulum gatekeeper. Molecular Psychiatry, 2016, 21, pp.480-490. ⟨10.1038/mp.2015.72⟩. ⟨inserm-01153352⟩
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Stéphane Lolignier, Dimitra Gkika, David Andersson, Enrico Leipold, Irina Vetter, et al.. New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives. Journal of Neuroscience, 2016, 36 (45), pp.11435 – 11439. ⟨10.1523/jneurosci.2327-16.2016⟩. ⟨hal-03512571⟩
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Stéphane Lolignier, Alain Eschalier, Caroline Bonnet, Patrick Delmas, Jérôme Busserolles. Le canal Nav1.9 : protéine clé pour la perception du froid et cible thérapeutique potentielle contre la douleur. Médecine/Sciences, 2016, 32 (2), pp.162 – 165. ⟨10.1051/medsci/20163202009⟩. ⟨hal-01795185⟩
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2015

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Estelle Ayme-Dietrich, Halim Marzak, Roland Lawson, Walid Mokni, Olivia Wendling, et al.. Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats. Journal of Hypertension, 2015, 33 (11), pp.2310 – 2321. ⟨10.1097/HJH.0000000000000695⟩. ⟨hal-01593863⟩
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Sophie M. Banas, Silvina L. Diaz, Stéphane Doly, Arnauld Belmer, Luc Maroteaux. Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift. Frontiers in Behavioral Neuroscience, 2015, 9, pp.207. ⟨10.3389/fnbeh.2015.00207⟩. ⟨hal-01225050v2⟩
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Silvina Laura Diaz, Nicolas Narboux-Nême, Katia Boutourlinsky, Stéphane Doly, Luc Maroteaux. Mice lacking the serotonin 5-HT2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants.. European Neuropsychopharmacology, 2015, 26 (2), pp.265-279. ⟨10.1016/j.euroneuro.2015.12.012⟩. ⟨hal-01253863⟩
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Stéphane Doly, Stefano Marullo. Gatekeepers Controlling GPCR Export and Function. Trends in Pharmacological Sciences, 2015, 36 (10), pp.636-644. ⟨10.1016/j.tips.2015.06.007⟩. ⟨hal-02485721⟩
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Marion Fauré, Valérie Paulmier, Alice de Boyer Des Roches, Alain Boissy, Claudia Terlouw, et al.. Douleurs animales. 2. Evaluation et traitement de la douleur chez les ruminants. INRA Productions Animales, 2015, 28 (3), pp.217-280. ⟨hal-02635722⟩
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Jérémy Ferrier, Mathilde Bayet-Robert, Romain Dalmann, Abderrahim El Guerrab, Youssef Aissouni, et al.. Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception. Journal of Neuroscience, 2015, 35 (50), pp.16418-16430. ⟨10.1523/JNEUROSCI.1537-15.2015⟩. ⟨hal-04323801⟩
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Amit Khairnar, Fabien Marchand, Aurélien Vidal, Monique Etienne, Imen Miladi, et al.. 99m Tc-NTP 15-5 Imaging for Cartilage Involvement in Experimental Rheumatoid Arthritis: Comparison with Routinely Used Molecular Imaging Methods and Sensitivity to Chronic Nonsteroidal Antiinflammatory Drug Treatment. Journal of Nuclear Medicine, 2015, 56 (5), pp.798-804. ⟨10.2967/jnumed.114.151415⟩. ⟨hal-04317355⟩
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Jennifer Koenig, Robert Werdehausen, John E Linley, Abdella M Habib, Jeffrey Vernon, et al.. Regulation of Na v 1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia. PLoS ONE, 2015, 10 (6), pp.e0128830. ⟨10.1371/journal.pone.0128830⟩. ⟨hal-03512591⟩
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Stéphane Lolignier, Caroline Bonnet, Christelle Gaudioso, Jacques Noël, Jérôme Ruel, et al.. The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia. Cell Reports, 2015, ⟨10.1016/j.celrep.2015.04.027⟩. ⟨hal-01208540⟩
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Michael S Minett, Vanessa Pereira, Shafaq Sikandar, Ayako Matsuyama, Stéphane Lolignier, et al.. Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7. Nature Communications, 2015, 6, pp.8967. ⟨10.1038/ncomms9967⟩. ⟨hal-03512580⟩
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2014

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Arnauld Belmer, Stephane Doly, Vincent Setola, Sophie M. Banas, Imane Moutkine, et al.. Role of the N-terminal region in G protein-coupled receptor functions: negative modulation revealed by 5-HT2B receptor polymorphisms.. Molecular Pharmacology, 2014, 85 (1), pp.127-38. ⟨10.1124/mol.113.089086⟩. ⟨inserm-00996746⟩
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Stéphanie Grégoire, Anne-Sophie Wattiez, Monique Etienne, Fabien Marchand, Denis Ardid. Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine. European Journal of Pharmacology, 2014, 735, pp.1-9. ⟨10.1016/j.ejphar.2014.03.056⟩. ⟨hal-04317364⟩
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Stéphane Lolignier, Niels Eijkelkamp, John N Wood. Mechanical allodynia. Pflügers Archiv European Journal of Physiology, 2014, 467 (1), pp.133 – 139. ⟨10.1007/s00424-014-1532-0⟩. ⟨hal-03512600⟩
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Kathryn Paterson, Stéphane Lolignier, John N Wood, Stephen B Mcmahon, David L H Bennett. Botulinum Toxin-A Treatment Reduces Human Mechanical Pain Sensitivity and Mechanotransduction. Annals of Neurology, 2014, 75 (4), pp.591-596. ⟨10.1002/ana⟩. ⟨hal-03512611⟩
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Bérengère Petit, Fabrice Giraudet, Céline Béchon, Laurent Bardin, Paul Avan, et al.. Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli: involvement of central sensitization. Neurobiology of Disease, 2014, 65, pp.55-68. ⟨10.1016/j.nbd.2014.01.005⟩. ⟨hal-03768897⟩
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Karine Thibault, Bernard Calvino, Isabelle Rivals, Fabien Marchand, Sophie Dubacq, et al.. Molecular Mechanisms Underlying the Enhanced Analgesic Effect of Oxycodone Compared to Morphine in Chemotherapy-Induced Neuropathic Pain. PLoS ONE, 2014, 9 (3), pp.e91297. ⟨10.1371/journal.pone.0091297⟩. ⟨hal-03242248⟩
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2013

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M.C. Boutterin, P. Mazot, C. Faure, S. Doly, N. Gervasi, et al.. Control of ALK (wild type and mutated forms) phosphorylation: Specific role of the phosphatase PTP1B. Cellular Signalling, 2013, 25 (6), pp.1505-1513. ⟨10.1016/j.cellsig.2013.02.020⟩. ⟨hal-03037733⟩
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Naoual Bouzidi, Hemantkumar Deokar, Alexandre Vogrig, Benjamin Boucherle, Isabelle Ripoche, et al.. Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents. Bioorganic and Medicinal Chemistry Letters, 2013, 23, pp.2624-2627. ⟨10.1016/j.bmcl.2013.02.100⟩. ⟨hal-00846217⟩
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Maïly Devilliers, Jérôme Busserolles, Stéphane Lolignier, Emmanuel Deval, Vanessa Pereira, et al.. Activation of TREK-1 by morphine results in analgesia without adverse side effects. Nature Communications, 2013, 4, ⟨10.1038/ncomms3941⟩. ⟨hal-01689367⟩
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Alexandre Vogrig, Liam Dorr, Naoual Bouzidi, Benjamin Boucherle, Anne-Sophie Wattiez, et al.. Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity. ACS Chemical Biology, 2013, 8, pp.2209-2216. ⟨10.1021/cb400308u⟩. ⟨hal-00948867⟩
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Anne-Sophie Wattiez, Xavier Pichon, Amandine Dupuis, Alejandro Hernández, Anne-Marie Privat, et al.. Disruption of 5-HT2A Receptor-PDZ Protein Interactions Alleviates Mechanical Hypersensitivity in Carrageenan-Induced Inflammation in Rats. PLoS ONE, 2013, 8 (9), pp.e74661. ⟨10.1371/journal.pone.0074661⟩. ⟨hal-04323765⟩
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2012

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Silviana Laura Diaz, Stéphane Doly, Nicolas Narboux-Nême, Sébasatien Fernández, Pierre Mazot, et al.. 5-HT(2B) receptors are required for serotonin-selective antidepressant actions.. Molecular Psychiatry, 2012, 17 (2), pp.154-63. ⟨10.1038/mp.2011.159⟩. ⟨inserm-00652573⟩
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https://inserm.hal.science/inserm-00652573/file/MolPsy_Diaz.pdf


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Jean-Marie Launay, Philippe Hervé, Jacques Callebert, Ziad Mallat, Corinne Collet, et al.. Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension.. Blood, 2012, 119 (7), pp.1772-80. ⟨10.1182/blood-2011-06-358374⟩. ⟨inserm-00996752⟩
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Aurélie Plas, Fabien Marchand, Alain Eschalier, Yves Troin, Pierre Chalard. Stereoselective Synthesis and In Vivo Evaluation of the Analgesic Activity of Polysubstituted Bispidines. European Journal of Organic Chemistry, 2012, pp.6070-6079. ⟨hal-00785184⟩
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Nataliya Urtikova, Nadège Berson, Juliette van Steenwinckel, Stéphane Doly, Jérémy Truchetto, et al.. Anti-nociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain.. Pain, 2012, 153 (6), pp.1320-31. ⟨10.1016/j.pain.2012.03.024⟩. ⟨hal-01225065⟩
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2011

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Sophie M. Banas, Stéphane Doly, Katia Boutourlinsky, Silvina L. Diaz, Arnauld Belmer, et al.. Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT(2B) Receptors for Dexfenfluramine Anorectic Effects.. Neuropsychopharmacology, 2011, 36 (2), pp.423-33. ⟨10.1038/npp.2010.173⟩. ⟨hal-00583533v2⟩
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Odile Boespflug-Tanguy, Patrick Aubourg, Imen Dorboz, Mélina Bégou, Geneviève Giraud, et al.. Neurodegenerative Disorder Related to AIMP1/p43 Mutation Is Not a PMLD. American Journal of Human Genetics, 2011, 88 (3), pp.392-393. ⟨10.1016/j.ajhg.2010.12.015⟩. ⟨hal-03768914⟩
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Richard d’Mello, Fabien Marchand, Sophie Pezet, Stephen Mcmahon, Anthony Dickenson. Perturbing PSD-95 Interactions With NR2B-subtype Receptors Attenuates Spinal Nociceptive Plasticity and Neuropathic Pain. Molecular Therapy, 2011, 19 (10), pp.1780-1792. ⟨10.1038/mt.2011.42⟩. ⟨hal-03242252⟩
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Juliette Descoeur, Vanessa Pereira, Anne Pizzoccaro, Amaury François, Bing Ling, et al.. Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Molecular Medicine, 2011, 3 (5), pp.266-278. ⟨10.1002/emmm.201100134⟩. ⟨hal-02370551⟩
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Stéphane Lolignier, Muriel Amsalem, François Maingret, Françoise Padilla, Mélanie Gabriac, et al.. Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation. PLoS ONE, 2011, 6 (8), pp.23083. ⟨10.1371/journal.pone.0023083⟩. ⟨hal-01689907⟩
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Fabien Marchand, Richard d’Mello, Ping Yip, Margarita Calvo, Emilie Muller, et al.. Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat. Molecular Pain, 2011, 7 (1), pp.86. ⟨10.1186/1744-8069-7-86⟩. ⟨inserm-00657507⟩
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Nicolas Narboux-Nême, Corinne Sagné, Stephane Doly, Silvina L Diaz, Cédric Bp Martin, et al.. Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Neuropsychopharmacology, 2011, 36, pp.2538-2550. ⟨10.1038/npp.2011.142⟩. ⟨hal-00665880⟩
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2010

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Laura Bevilacqua, Stéphane Doly, Jaakko Kaprio, Qiaoping Yuan, Roope Tikkanen, et al.. A population-specific HTR2B stop codon predisposes to severe impulsivity.. Nature, 2010, 468 (7327), pp.1061-6. ⟨10.1038/nature09629⟩. ⟨inserm-00550376⟩
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Laurent Monassier, Marc André Laplante, Tarak Ayadi, Stéphane Doly, Luc Maroteaux. Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin.. Pharmacology and Therapeutics, 2010, 128 (3), pp.559-67. ⟨10.1016/j.pharmthera.2010.08.004⟩. ⟨inserm-00549197v2⟩
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Lusliany Rondón, A. M. Privat, L. Daulhac, N. Davin, André Mazur, et al.. Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain. The Journal of Physiology, 2010, 588 (21), pp.4205 – 4215. ⟨10.1113/jphysiol.2010.197004⟩. ⟨hal-02662281⟩
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2009

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Wadie Ben Hassen, Mélina Bégou, Amidou A. Traore, Abdelatif Ben Moussa, Nelly Boehm, et al.. Characterisation of spinal cord in a mouse model of spastic paraplegia related to abnormal axono-myelin interactions by in vivo quantitative MRI.. NeuroImage, 2009, 46 (1), pp.1-9. ⟨10.1016/j.neuroimage.2009.01.022⟩. ⟨hal-02660406⟩
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Jean-Baptiste Bertrand, Jean-Baptiste Langlois, Mélina Bégou, Julien Volle, Philippe Brun, et al.. Longitudinal MRI monitoring of brain damage in the neonatal ventral hippocampal lesion rat model of schizophrenia.. Hippocampus, 2009, epub ahead of print. ⟨10.1002/hipo.20628⟩. ⟨hal-00397785⟩
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Stéphane Doly, Jesus Bertran-Gonzalez, Jacques Callebert, Alexandra Bruneau, Sophie Marie Banas, et al.. Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice.. PLoS ONE, 2009, 4 (11), pp.e7952. ⟨10.1371/journal.pone.0007952⟩. ⟨inserm-00484504⟩
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Fabrice Jaffré, Philippe Bonnin, Jacques Callebert, Haythem Debbabi, Vincent Setola, et al.. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.. Circulation Research, 2009, 104 (1), pp.113-23. ⟨10.1161/CIRCRESAHA.108.180976⟩. ⟨inserm-00484528⟩
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2008

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Mélina Bégou, Julien Volle, Jean Batiste Bertrand, Philippe Brun, Didier Job, et al.. The stop null mice model for schizophrenia displays [corrected] cognitive and social deficits partly alleviated by neuroleptics.. Neuroscience, 2008, 157 (1), pp.29-39. ⟨10.1016/j.neuroscience.2008.07.080⟩. ⟨inserm-00375621⟩
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https://inserm.hal.science/inserm-00375621/file/08-05-16_Cognitiv_defects_in_KO_STOPAA2.pdf


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Carine Chassain, Guy Bielicki, Elodie Durand, Stéphane Lolignier, Fatma Essafi, et al.. Metabolic changes detected by proton magnetic resonance spectroscopy in vivo and in vitro in a murin model of Parkinson’s disease, the MPTP-intoxicated mouse. Journal of Neurochemistry, 2008, 105 (3), pp.874-882. ⟨10.1111/j.1471-4159.2007.05185.x⟩. ⟨hal-01602181⟩
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Stéphane Doly, Emmanuel Valjent, Vincent Setola, Jacques Callebert, Denis Hervé, et al.. Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro.. Journal of Neuroscience, 2008, 28 (11), pp.2933-40. ⟨10.1523/JNEUROSCI.5723-07.2008⟩. ⟨inserm-00484533⟩
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Sophie Pezet, F. Marchand, R. d’Mello, J. Grist, A. Clark, et al.. Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions. Journal of Neuroscience, 2008, 28 (16), pp.4261-4270. ⟨10.1523/JNEUROSCI.5392-07.2008⟩. ⟨hal-03242270⟩
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2007

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Mélina Bégou, Philippe Brun, Jean-Baptiste Bertrand, Didier Job, Annie Schweitzer, et al.. Post-pubertal emergence of alterations in locomotor activity in stop null mice.. Synapse, 2007, 61 (9), pp.689-97. ⟨10.1002/syn.20409⟩. ⟨inserm-00379954⟩
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2006

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Annie Andrieux, Paul A. Salin, Annie Schweitzer, Mélina Bégou, Bastien Pachoud, et al.. Microtubule stabilizer ameliorates synaptic function and behavior in a mouse model for schizophrenia.. Biological Psychiatry, 2006, 60 (11), pp.1224-30. ⟨10.1016/j.biopsych.2006.03.048⟩. ⟨inserm-00380045⟩
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2005

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Philippe Brun, Mélina Bégou, Annie Andrieux, Laurence Mouly-Badina, Magali Clerget, et al.. Dopaminergic transmission in STOP null mice.. Journal of Neurochemistry, 2005, 94 (1), pp.63-73. ⟨10.1111/j.1471-4159.2005.03166.x⟩. ⟨inserm-00380189⟩
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S. Doly, J. Fischer, M.J. Brisorgueil, D. Vergé, M. Conrath. Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal spinal cord: Immunocytochemical evidence.. Journal of Comparative Neurology, 2005, pp.269. ⟨hal-00110191⟩
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2004

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S. Doly, A. Madeira, J. Fischer, M.-J. Brisorgueil, G. Daval, et al.. The 5-HT2A receptor is widely distributed in the rat spinal cord and mainly localized at the plasma membrane of postsynaptic neurons.. Journal of Comparative Neurology, 2004. ⟨hal-00110107⟩
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S. Doly, J. Fischer, M. Conrath. The vanilloid receptor-1 (TRPV1) is expressed in some rat dorsal horn NK1 cells.. Brain Research, 2004, pp.207. ⟨hal-00110126⟩
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S. Doly, J. Fischer, C. Salio, M. Conrath. The vanilloid receptor-1 is expressed in rat spinal dorsal horn astrocytes.. Neuroscience Letters, 2004, pp.126. ⟨hal-00110211⟩
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S. Doly, J. Fischer, Mj. Brisorgueil, D. Vergé, M. Conrath. 5-HT5A receptor immunoreactivity in the rat spinal cord suggests a role in nociception and control of pelvic organs.. Journal of Comparative Neurology, 2004. ⟨hal-00110123⟩
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2002

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C. Salio, S. Doly, J. Fischer, Mf. Franzoni, M. Conrath. Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord.. Neuroscience Letters, 2002, pp.16. ⟨hal-00110118⟩
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2001

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M. Conrath, J. Fischer, C. Salio, Mf. Franzoni, S. Doly. Vanilloïdes, cannabinoïdes et nociception: aspects anatomiques.. Douleur et Analgésie, 2001, pp.190. ⟨hal-00110115⟩
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C. Pean, A. Wijkhuisen, F. Djedaïni-Pilard, J. Fischer, S. Doly, et al.. Pharmacological in vitro evaluation of new substance P-cyclodextrin derivatives designed to drug targeting towards NK-1 receptor bearing cells.. BBA – Biochimica et Biophysica Acta, 2001, pp.160. ⟨hal-00110112⟩
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Conference papers

2003

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S. Doly, J. Fischer, M.J. Brisorgueil, R. Bernard, D. Vergé, et al.. Distribution cellulaire et subcellulaire des récepteurs 5-HT2A, 5-HT5A et 5-HT7 dans la moelle épinière du rat en relation avec les terminaisons des fibres afférentes primaires. 2003, pp.ROUEN : 13/05/03-16/05/03. ⟨hal-00109470⟩
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S. Doly, J. Fischer, M.J. Brisorgueil, R. Bernard, D. Vergé, et al.. Cellular and subcellular distribution of 5-HT2A, 5-HT5A and 5-HT7 receptors in the spinal cord: relationships with primary afferent fibers. 2003, pp.Prague 10/07/03-15/07/03. ⟨hal-00109498⟩
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2002

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S. Doly, J. Fischer, M. Conrath. Vanilloid receptor-1 (VR1) in rat spinal cord in normal rat and in a model of neuropathic pain.. 3éme Journées Internationales de Deauville sur la pathologie médullaire, 2002, Deauville : 10-12 Avril, France. ⟨hal-00110208⟩
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S. Doly, J. Fischer, C. Salio, M. Conrath. Ubiquitous distribution of vanilloid receptor-1 (VR1) in the rat spinal cord.. FENS Forum, 2002, paris, France. pp.13-17 july. ⟨hal-00110128⟩
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2001

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S. Doly, J. Fischer, C. Péan, C. Créminon, A. Wijkhuisen, et al.. Le complexe cyclodextrine-substance P peut-il être utilisé comme vecteur de drogue vers les cellules NK1?. Congrès National de la Société des Neurosciences Françaises, 2001, Toulouse : 27-30 Mai, France. ⟨hal-00110178⟩
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Book sections

2018

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Luc Maroteaux, Anne Roumier, Stéphane Doly, Silvina Laura Diaz, Arnauld Belmer. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules, Springer International Publishing, pp.2458-2481, 2018, ISBN 978-3-319-67198-7. ⟨10.1007/978-3-319-67199-4⟩. ⟨inserm-03986853⟩
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https://inserm.hal.science/inserm-03986853/file/Encyclop_2B_Maroteaux.pdf


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Habilitation à diriger des recherches

2023

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Mélina Bégou. Implication du stress oxydant et du dysfonctionnement mitochondrial dans la genèse des symptômes sensitifs au cours des pathologies dysmyélinisantes – Etudes physiopathologiques et approches thérapeutiques. Sciences du Vivant [q-bio]. Université Clermont Auvergne (UCA), 2023. ⟨tel-04719254⟩
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https://hal.science/tel-04719254/file/HDR%20M%C3%A9lina%20BEGOU%202023.pdf


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Poster communications

2023

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Nazarine Mokhtar, Marcin Drop, Frédéric Lamaty, Paweł Zajdel, Philippe Marin, et al.. Diabetic neuropathic pain improvement by inhibition of constitutive 5-HT 6 receptor activity in rats. Neuropathic Pain Special Interest Group (NeuPSIG) 2023 International Congress on Neuropathic Pain, Sep 2023, Lisbon, Portugal. ⟨hal-04324131⟩
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https://hal.science/hal-04324131/file/NeuPSIG2023_Printable_Poster.%20Mokhtar%202023.pdf


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2022

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R. Auguste, E. Jagu, C. Courteix, S. Ducki. Targeting PDZ-mediated protein-protein interactions against neuropathic pain.. European School of Medicinal Chemistry ESMEC, 41st Advanced Course of Medicinal Chemistry and Seminar for PhD students, Jul 2022, Urbino, Italy. ⟨hal-04069002⟩
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2021

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R. Auguste, E. Jagu, C. Courteix, A. Dumeige, S. Ducki. Targeting PDZ-mediated protein-protein interactions against neuropathic pain.. 56èmes Rencontres Internationales de Chimie Thérapeutiques (RICT 2021), Jul 2021, Virtual Event, France. ⟨hal-03468434⟩
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2019

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Florian Jacquot, Julie Barbier, Denis Ardid, Fabien Marchand. Peripheral ASIC3 activation by lysophosphatidyl-choline induced chronic joint pain and associated anxiety in mice. Neuroscience 2019, Congress of Society of Neuroscience, Oct 2019, CHICAGO, United States. ⟨hal-02363978⟩
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Theses

2018

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Lauriane Delay. La douleur chronique articulaire dans la polyarthrite rhumatoïde : rôle des canaux ASIC3 dans l’athralgie induite par les ACPA et des voies de signalisation NGF/TrkA dans la douleur chronique inflammatoire. Neurosciences [q-bio.NC]. Université Clermont Auvergne [2017-2020], 2018. Français. ⟨NNT : 2018CLFAS017⟩. ⟨tel-02918095⟩
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https://theses.hal.science/tel-02918095/file/2018CLFAS017_DELAY.pdf


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2011

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Stéphane Lolignier. Rôle du canal sodique Nav1.9 dans la douleur inflammatoire, dans la perception du froid et dans l’hypersensibilité au froid induite par l’oxaliplatine. Médecine humaine et pathologie. Université d’Auvergne – Clermont-Ferrand I, 2011. Français. ⟨NNT : 2011CLF1MM28⟩. ⟨tel-00855512⟩
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https://theses.hal.science/tel-00855512/file/2011CLF1MM28.pdf


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Preprints, Working Papers, …

2021

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Florian Jacquot, Spiro Khoury, Bonnie Labrum, Kevin Delanoe, Ludivine Pidoux, et al.. Lysophosphatidyl-choline 16:0 mediates persistent joint pain through Acid-Sensing Ion Channel 3: preclinical and clinical evidences. 2021. ⟨hal-03187657⟩
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https://hal.science/hal-03187657/file/2021.03.29.437487v3.ful.pdf


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