Field of research

The “Patient” research axis aims to better characterize patients suffering from chronic pain and to improve their care. The themes covered include the use and misuse of analgesics, the characterization of subpopulations of chronic pain patients, and the monitoring of cohorts of fibromyalgia patients. In addition, the identification of predictive factors of the evolution of the clinical situation is essential to optimize treatments and provide personalized care.

Team leaders

Members

HAL Publication

Journal articles

2024

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David Balayssac, Nicolas Kerckhove, Marie Selvy, Bruno Pereira, Coralie Gonneau, et al.. Motor disorders related to oxaliplatin-induced peripheral neuropathy: long-term severity and impact on quality of life. Supportive Care in Cancer, 2024, 32 (7), pp.427. ⟨10.1007/s00520-024-08627-8⟩. ⟨hal-04619673⟩
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https://hal.science/hal-04619673/file/PREVOX%20motor%20-%20Supp%20Care%20Cancer%20-%20Manuscript%20HAL.pdf

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Noémie Delage, Nathalie Cantagrel, Sandrine Soriot-Thomas, Marie Frost, Rodrigue Deleens, et al.. Mobile Health App and Web Platform (eDOL) for Medical Follow-Up of Patients With Chronic Pain: Cohort Study Involving the French eDOL National Cohort After 1 Year. JMIR mHealth and uHealth, 2024, 12, pp.e54579. ⟨10.2196/54579⟩. ⟨hal-04617487⟩
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https://hal.science/hal-04617487/file/mhealth-2024-1-e54579.pdf


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Angeline Ginzac, Emilie Thivat, Caroline Petorin, Damien Richard, Pauline Herviou, et al.. A phase-II study based on dose adjustment according to UGT1A1 polymorphism: is irinotecan underdosed in first-line FOLFIRI regimen for mCRC?. Cancer Chemotherapy and Pharmacology, 2024, 93 (3), pp.225-236. ⟨10.1007/s00280-023-04603-x⟩. ⟨hal-04297253⟩
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https://hal.science/hal-04297253/file/Article%20IriGen_publi%C3%A9.pdf


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Xavier Moisset, Emmanuelle Leray, Chouki Chenaf, Frederic Taithe, Sandra Vukusic, et al.. Risk of Relapse After COVID-19 Vaccination Among Patients With Multiple Sclerosis in France. Neurology, 2024, 103 (5), pp.e209662. ⟨10.1212/wnl.0000000000209662⟩. ⟨hal-04698925⟩
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https://hal.science/hal-04698925/file/Final_240415_clean.pdf

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2023

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Virginie Guastella, Annick Greil, C. Lambert, Alexandre Lautrette. Reply to ‘Response to “The opinion of French pulmonologists and palliative care physicians on non-invasive ventilation during palliative sedation at end of life: a nationwide survey’’ ’. BMC Palliative Care, 2023, 22 (1), pp.17. ⟨10.1186/s12904-023-01128-1⟩. ⟨hal-04127143⟩
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https://uca.hal.science/hal-04127143/file/Response%20to%20Twycross%20and%20al.pdf


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Marie Lavarelo Marcolin, Andréa Tarot, Véronique Lombardo, Bruno Pereira, A. van Lander, et al.. The effects of foot reflexology on symptoms of discomfort in palliative care: a feasibility study. BMC Complementary Medicine and Therapies, 2023, 23, pp.66. ⟨10.1186/s12906-023-03873-5⟩. ⟨hal-04127088⟩
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https://uca.hal.science/hal-04127088/file/article%20reflexo.pdf


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Elodie Picard, Nicolas Kerckhove, Amaury François, Ludivine Boudieu, Elisabeth Billard, et al.. Role of T CD4+ cells, macrophages, C-low threshold mechanoreceptors and spinal Cav3.2 channels in inflammation and related pain-like symptoms in murine inflammatory models. British Journal of Pharmacology, 2023, 180 (4), pp.385-400. ⟨10.1111/bph.15956⟩. ⟨hal-03790651⟩
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Fabien Wauquier, Doriane Ripoche, Line Boutin-Wittrant, Yolanda F Otero, Florian Le Joubioux, et al.. Circulating bioactives resulting from totum-854 absorption in humans protects primary human endothelial cells against lipotoxicity: lessons from an original ex vivo clinical trial. Journal of Hypertension -Supplement-, 2023, 41, pp.E308-E308. ⟨hal-04323875⟩
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2022

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Celian Bertin, Julien Bezin, Chouki Chenaf, Jessica Delorme, Nicolas Kerckhove, et al.. Oral Morphine as an Alternative Substitution Treatment for Opioid Use Disorder, a Rare but Non-risk-free Use. Frontiers in Psychiatry, 2022, 13, ⟨10.3389/fpsyt.2022.893590⟩. ⟨hal-03815296⟩
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https://hal.science/hal-03815296/file/BPH_FP_2022_Bertin.pdf


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Alexandrine Corriger, Marion Voute, Céline Lambert, Bruno Pereira, Gisèle Pickering. Ketamine for refractory chronic pain: a 1-year follow-up study. Pain, 2022, 163 (4), pp.690-701. ⟨10.1097/j.pain.0000000000002403⟩. ⟨hal-04256432⟩
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Noémie Delage, Nathalie Cantagrel, Jessica Delorme, Bruno Pereira, Christian Dualé, et al.. Transcultural validation of a French–European version of the Prescription Opioid Misuse Index Scale (POMI-5F). Canadian Journal of Anesthesia / Journal canadien d’anesthésie, 2022, 69 (8), pp.1042-1052. ⟨10.1007/s12630-022-02210-7⟩. ⟨hal-04256540⟩
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Noémie Delage, Nathalie Cantagrel, Jessica Delorme, Bruno Pereira, Christian Dualé, et al.. Transcultural validation of a French–European version of the Prescription Opioid Misuse Index Scale (POMI-5F). Canadian Journal of Anesthesia / Journal canadien d’anesthésie, 2022, 69 (8), pp.1042-1052. ⟨10.1007/s12630-022-02210-7⟩. ⟨hal-04741710⟩
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Fabrice Giraudet, Marie Selvy, Nicolas Kerckhove, Bruno Pereira, Fantine Barreau, et al.. Relation between auditory difficulties and bortezomib-induced peripheral neuropathy in multiple myeloma: a single-center cross-sectional study. European Archives of Oto-Rhino-Laryngology, 2022, 279 (4), pp.2197-2201. ⟨10.1007/s00405-021-07234-1⟩. ⟨hal-03813006⟩
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Nicolas Kerckhove, Noémie Delage, Sébastien Cambier, Nathalie Cantagrel, Eric Serra, et al.. eDOL mHealth App and Web Platform for Self-monitoring and Medical Follow-up of Patients With Chronic Pain: Observational Feasibility Study. JMIR Formative Research, 2022, 6 (3), pp.e30052. ⟨10.2196/30052⟩. ⟨hal-04256443⟩
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Nicolas Kerckhove, David Tougeron, Côme Lepage, Denis Pezet, Karine Le Malicot, et al.. Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial. BMC Cancer, 2022, 22 (1), pp.1-11. ⟨10.1186/s12885-022-09806-8⟩. ⟨hal-03770150⟩
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https://hal.inrae.fr/hal-03770150/file/2022_Kerckhove_BMC_Cancer.pdf


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Nicolas Kerckhove, Noémie Delage, Sébastien Cambier, Nathalie Cantagrel, Eric Serra, et al.. eDOL mHealth App and Web Platform for Self-monitoring and Medical Follow-up of Patients With Chronic Pain: Observational Feasibility Study. JMIR Formative Research, 2022, 6 (3), pp.e30052. ⟨10.2196/30052⟩. ⟨hal-04744373⟩
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Nicolas Kerckhove, Noémie Delage, Célian Bertin, Emmanuelle Kuhn, Nathalie Cantagrel, et al.. Cross-sectional study of the prevalence of prescription opioids misuse in French patients with chronic non-cancer pain: An update with the French version of the POMI scale. Frontiers in Pharmacology, 2022, 13, ⟨10.3389/fphar.2022.947006⟩. ⟨hal-04256522⟩
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Catherine Laporte, Frédéric Fortin, Julie Dupouy, Aurélie Quirin, Bruno Pereira, et al.. Real-Life Testing of the Prescription Opioid Misuse Index in French Primary Care. International Journal of Environmental Research and Public Health, 2022, 19 (22), pp.14845. ⟨10.3390/ijerph192214845⟩. ⟨hal-04184143⟩
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https://hal.science/hal-04184143/file/ijerph-19-14845-v4.pdf


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Céline Preux, Marion Bertin, Andréa Tarot, Nicolas Authier, Nathalie Pinol, et al.. Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review. Journal of Clinical Medicine, 2022, 11 (6), pp.1594. ⟨10.3390/jcm11061594⟩. ⟨hal-03983745⟩
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https://hal.science/hal-03983745/file/jcm-11-01594.pdf


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Benjamin Rolland, Caroline Lions, Vincent Di Beo, Patrizia Carrieri, Nicolas Authier, et al.. Adherence to opioid agonist therapy predicts uptake of direct-acting antivirals in people who use drugs: results from the French national healthcare database (the ANRS FANTASIO study). Harm Reduction Journal, 2022, 19 (1), pp.119. ⟨10.1186/s12954-022-00702-9⟩. ⟨inserm-04050246⟩
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https://inserm.hal.science/inserm-04050246/file/s12954-022-00702-9.pdf


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Anne-Priscille Trouvin, Chouki Chenaf, Marie Riquelme, Emmanuel Curis, Ioannis Nicolis, et al.. Crise des opioïdes : la pratique rhumatologique augmente-t-elle le risque pour les patients ? Enquête nationale sur la prescription d’opioïdes par les rhumatologues et l’adhésion aux recommandations relatives à l’utilisation des opioïdes forts. Revue du Rhumatisme, 2022, 89 (2), pp.145–152. ⟨10.1016/j.rhum.2021.10.007⟩. ⟨hal-03831134⟩
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A van Lander, A Bioy, V Guastella. Étude observationnelle des comportements familiaux durant la phase palliative terminale. Psycho-Oncologie, 2022, 16 (2), pp.234-242. ⟨10.3166/pson-2022-0196⟩. ⟨hal-03702989⟩
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2021

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David Balayssac, Bruno Pereira, Pierre Cuq, Juliette Douris, Luc Ferrari, et al.. Perception of pharmacy students toward opioid-related disorders and roles of community pharmacists: A French nationwide cross-sectional study. Substance Abuse, 2021, 42 (4), pp.706-715. ⟨10.1080/08897077.2020.1850607⟩. ⟨hal-03077594⟩
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Célian Bertin, Noémie Delage, Benjamin Rolland, Lucie Pennel, Mélina Fatseas, et al.. Analgesic opioid use disorders in patients with chronic non-cancer pain: A holistic approach for tailored management. Neuroscience and Biobehavioral Reviews, 2021, 121, pp.160 – 174. ⟨10.1016/j.neubiorev.2020.12.015⟩. ⟨hal-03493763⟩
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https://hal.science/hal-03493763/file/S0149763420306928.pdf


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Jessica Delorme, Lucie Pennel, Georges Brousse, Jean-Pierre Daulouède, Jean-Michel Delile, et al.. Prevalence and Characteristics of Chronic Pain in Buprenorphine and Methadone-Maintained Patients. Frontiers in Psychiatry, 2021, 12, ⟨10.3389/fpsyt.2021.641430⟩. ⟨hal-03583962⟩
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Jessica Delorme, Célian Bertin, Noémie Delage, Alain Eschalier, Denis Ardid, et al.. Prevalence of chronic pain in opioid-maintained patients using the capture–recapture method: a nationwide population-based study. Pain, 2021, 162 (1), pp.195-202. ⟨10.1097/j.pain.0000000000002011⟩. ⟨hal-04316546⟩
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Marie Gerardin, Morgane Rousselet, Marie-Laure Couec, Agathe Masseau, Marylène Guerlais, et al.. Descriptive analysis of sickle cell patients living in France. PLoS ONE, 2021, 16 (3), pp.e0248649. ⟨10.1371/journal.pone.0248649⟩. ⟨hal-03407019⟩
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https://univ-tours.hal.science/hal-03407019/file/journal.pone.0248649.pdf


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Virginie Guastella, Gaël Piwko, Annick Greil, C. Lambert, Alexandre Lautrette. The opinion of French pulmonologists and palliative care physicians on non-invasive ventilation during palliative sedation at end of life: a nationwide survey. BMC Palliative Care, 2021, 20, ⟨10.1186/s12904-021-00755-w⟩. ⟨hal-04127130⟩
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https://uca.hal.science/hal-04127130/file/Guastella_et_al-2021-BMC_Palliative_Care.pdf


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Nicolas Kerckhove, Marie Selvy, Céline Lambert, Coralie Gonneau, Gabrielle Feydel, et al.. Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy. Frontiers in Pharmacology, 2021, 12, pp.1-10. ⟨10.3389/fphar.2021.744085⟩. ⟨hal-03498040⟩
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https://hal.inrae.fr/hal-03498040/file/2021_Kerckhove_Frontiers_in_Pharmacology.pdf


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Marie Selvy, Nicolas Kerckhove, Bruno Pereira, Fantine Barreau, Daniel Nguyen, et al.. Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study. Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.637593⟩. ⟨hal-03238418⟩
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https://hal.inrae.fr/hal-03238418/file/2021_Selvy_Front_Pharmacol.pdf


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Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Jérôme Busserolles, Fadila Farsi, et al.. Prevention, diagnosis and management of chemotherapy-induced peripheral neuropathy: a cross-sectional study of French oncologists’ professional practices. Supportive Care in Cancer, 2021, 29 (7), pp.4033-4043. ⟨10.1007/s00520-020-05928-6⟩. ⟨hal-03299953⟩
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Andréa Tarot, Jessica Delorme, Nicolas Authier, Virginie Guastella. Prescription d’opioïdes pour les patients atteints de cancer avec métastases osseuses ; étude pharmaco-épidémiologique nationale transversale. Bulletin du Cancer, 2021, 108 (12), pp.1120-1125. ⟨10.1016/j.bulcan.2021.08.006⟩. ⟨hal-04198540⟩
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https://uca.hal.science/hal-04198540/file/S0007455121003751.pdf


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Anne-Priscille Trouvin, Chouki Chenaf, Marie Riquelme, Emmanuel Curis, I. Nicolis, et al.. Opioid epidemic: Does rheumatological practice favors risk for patients? National survey on rheumatologists’ opioid prescriptions and compliance to guidelines for strong opioid prescription. Joint Bone Spine, 2021, 88 (1), pp.105046. ⟨10.1016/j.jbspin.2020.06.019⟩. ⟨hal-03831178⟩
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https://hal.science/hal-03831178/file/S1297319X20301317.pdf


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2020

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Jérôme Busserolles, Stéphane Lolignier, Nicolas Kerckhove, Célian Bertin, Nicolas Authier, et al.. Replacement of current opioid drugs focusing on MOR-related strategies. Pharmacology and Therapeutics, 2020, 210, pp.107519. ⟨10.1016/j.pharmthera.2020.107519⟩. ⟨hal-03490336⟩
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https://hal.science/hal-03490336/file/S0163725820300474.pdf


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Mélissa Cuménal, Marie Selvy, Nicolas Kerckhove, Célian Bertin, Margaux Morez, et al.. The Safety of Medications used to Treat Peripheral Neuropathic Pain, Part 2 (Opioids, Cannabinoids and Other Drugs): review of Double-Blind, Placebo-Controlled, Randomized Clinical Trials. Expert Opinion on Drug Safety, 2020, pp.1-18. ⟨10.1080/14740338.2021.1842871⟩. ⟨hal-02997543⟩
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https://uca.hal.science/hal-02997543/file/Medications_safety_2_-_EODS.pdf


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Lionel Noah, Gisèle Pickering, André Mazur, Claude Dubray, Simon Hitier, et al.. Impact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: secondary data from a randomized controlled trial. Magnesium Research, 2020, 33 (3), pp.45-57. ⟨10.1684/mrh.2020.0468⟩. ⟨hal-03042129⟩
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https://hal.inrae.fr/hal-03042129/file/2020_Noah_Magnesium_Res.pdf


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Gisèle Pickering, André Mazur, Marion Trousselard, Przemyslaw Bienkowski, Natalia Yaltsewa, et al.. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients, 2020, 12 (12), pp.3672. ⟨10.3390/nu12123672⟩. ⟨hal-03041446⟩
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https://hal.science/hal-03041446/file/2020_Pickering_Nutrients.pdf


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Marie Selvy, Mélissa Cuménal, Nicolas Kerckhove, Christine Courteix, Jérôme Busserolles, et al.. The safety of medications used to treat peripheral neuropathic pain, part 1 (antidepressants and antiepileptics): review of double-blind, placebo-controlled, randomized clinical trials. Expert Opinion on Drug Safety, 2020, 19 (6), pp.707-733. ⟨10.1080/14740338.2020.1764934⟩. ⟨hal-02997564⟩
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https://uca.hal.science/hal-02997564/file/Medications_safety_-_EODS.pdf


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Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Coralie Gonneau, Gabrielle Feydel, et al.. Long-Term Prevalence of Sensory Chemotherapy-Induced Peripheral Neuropathy for 5 Years after Adjuvant FOLFOX Chemotherapy to Treat Colorectal Cancer: A Multicenter Cross-Sectional Study. Journal of Clinical Medicine, 2020, 9 (8), pp.2400. ⟨10.3390/jcm9082400⟩. ⟨hal-02997588⟩
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https://uca.hal.science/hal-02997588/file/jcm-09-02400-v2.pdf


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Margot Smirdec, Mercé Jourdain, Virginie Guastella, Céline Lambert, Jean-Christophe Richard, et al.. Impact of advance directives on the variability between intensivists in the decisions to forgo life-sustaining treatment. Critical Care, 2020, 24 (1), pp.672. ⟨10.1186/s13054-020-03402-7⟩. ⟨hal-03040555⟩
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https://hal.science/hal-03040555/file/s13054-020-03402-7.pdf


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Juliana Tournebize, Valérie Gibaja, Elisabeth Frauger, Nicolas Authier, Dominique Seyer, et al.. Le mésusage du fentanyl en France : 2010 à 2015. Therapies, 2020, 75 (5), pp.491-502. ⟨10.1016/j.therap.2019.11.002⟩. ⟨hal-03141763⟩
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https://hal.science/hal-03141763/file/S004059571930174X.pdf


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Marion Voute, Véronique Morel, Dominique Joly, Christine Villatte, Elodie Martin, et al.. Predicting Pain Trajectories in the One Year Following Breast Cancer Diagnosis—An Observational Study. Journal of Clinical Medicine, 2020, 9 (6), pp.1907. ⟨10.3390/jcm9061907⟩. ⟨hal-02882206⟩
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https://hal.science/hal-02882206/file/jcm-09-01907-v2.pdf


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2019

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Tangui Barre, Fabienne Marcellin, Vincent Di Beo, Jessica Delorme, Teresa Rojas Rojas, et al.. Untreated alcohol use disorder in people who inject drugs (PWID) in France: a major barrier to HCV treatment uptake (the ANRS-FANTASIO study). Addiction, 2019, 115 (3), pp.573-582. ⟨10.1111/add.14820⟩. ⟨hal-02611930⟩
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https://amu.hal.science/hal-02611930/file/add.14820.pdf


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Célian Bertin, Jessica Delorme, Marie Riquelme, Hélène Peyriere, Georges Brousse, et al.. Risk assessment of using off‐label morphine sulfate in a population‐based retrospective cohort of opioid‐dependent patients. British Journal of Clinical Pharmacology, 2019, 86 (12), pp.2338-2348. ⟨10.1111/bcp.14082⟩. ⟨hal-02325453⟩
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Celian Bertin, Jessica Delorme, Marie Riquelme, Hélène Peyrière, Alain Eschalier, et al.. Toward a Triadic Approach to Craving in Addictive Disorders. Harvard Review of Psychiatry, 2019, 27 (5), pp.326-331. ⟨10.1097/HRP.0000000000000225⟩. ⟨hal-02384764⟩
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C. Chenaf, J.-L. Kaboré, J. Delorme, Bruno Pereira, A. Mulliez, et al.. Prescription opioid analgesic use in France: Trends and impact on morbidity-mortality. European Journal of Pain, 2019, 23 (1), pp.124-134. ⟨10.1002/ejp.1291⟩. ⟨hal-02323031⟩
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Alexandrine Corriger, Gisèle Pickering. Ketamine and depression: a narrative review. Drug Design, Development and Therapy, 2019, 13 (6), pp.3051-3067. ⟨10.2147/DDDT.S221437⟩. ⟨hal-04257286⟩
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Alexandrine Corriger, Martine Duclos, Jean-Benoît Corcuff, Céline Lambert, Geoffroy Marceau, et al.. Hormonal status and cognitivo‐emotional profile in real‐life neuropathic pain patients: a case control study. Pain Practice, 2019, 19 (7), ⟨10.1111/papr.12800⟩. ⟨hal-02193914⟩
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Maité Garrouste-Orgeas, Cécile Flahault, Edith Poulain, Adrien Evin, Frédéric Guirimand, et al.. The Fami-life study: protocol of a prospective observational multicenter mixed study of psychological consequences of grieving relatives in French palliative care units on behalf of the family research in palliative care (F.R.I.P.C research network). BMC Palliative Care, 2019, 18 (1), ⟨10.1186/s12904-019-0496-4⟩. ⟨hal-02526838⟩
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https://hal.umontpellier.fr/hal-02526838/file/s12904-019-0496-4.pdf


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Nicolas Kerckhove, Jérôme Busserolles, Trevor Stanbury, Bruno Pereira, Valérie Plence, et al.. Effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy: RILUZOX-01: protocol of a randomised, parallel, controlled, double-blind and multicentre study by the UNICANCER-AFSOS Supportive Care intergroup. BMJ Open, 2019, 9 (6), pp.e027770. ⟨10.1136/bmjopen-2018-027770⟩. ⟨hal-02325112⟩
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https://hal.science/hal-02325112/file/bmjopen-2018-027770.pdf


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Nicolas Kerckhove, Ludivine Boudieu, Guillaume Ourties, Justine Bourdier, Laurence Daulhac, et al.. Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors. European Neuropsychopharmacology, 2019, 29, pp.1419 – 1432. ⟨10.1016/j.euroneuro.2019.10.012⟩. ⟨hal-03488870⟩
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https://hal.science/hal-03488870/file/S0924977X19317249.pdf


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Catherine Laporte, Céline Lambert, Bruno Pereira, Olivier Blanc, Nicolas Authier, et al.. Cannabis users: Screen systematically, treat individually. A descriptive study of participants in a randomized trial in primary care. PLoS ONE, 2019, 14 (12), pp.e0224867. ⟨10.1371/journal.pone.0224867⟩. ⟨inserm-02406964⟩
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https://inserm.hal.science/inserm-02406964/file/journal.pone.0224867.pdf


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Elodie Martin, Marc Sorel, Véronique Morel, Fabienne Marcaillou, Pascale Picard, et al..

Dextromethorphan and memantine after ketamine analgesia: a randomized control trial

. Drug Design, Development and Therapy, 2019, Volume 13, pp.2677-2688. ⟨10.2147/DDDT.S207350⟩. ⟨hal-02325142⟩

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Rex Park, Anthony M-H Ho, Gisèle Pickering, Lars Arendt-Nielsen, Mohammed Mohiuddin, et al.. Magnesium for the Management of Chronic Noncancer Pain in Adults: Protocol for a Systematic Review. JMIR Research Protocols, 2019, 8 (1), pp.e11654. ⟨10.2196/11654⟩. ⟨hal-04257283⟩
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Rex Park, Anthony M-H Ho, Gisèle Pickering, Lars Arendt-Nielsen, Mohammed Mohiuddin, et al.. Magnesium for the Management of Chronic Noncancer Pain in Adults: Protocol for a Systematic Review. JMIR Research Protocols, 2019, 8 (1), pp.e11654. ⟨10.2196/11654⟩. ⟨hal-02324727⟩
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Gisèle Pickering, Marion Voute, Nicolas Macian, Hervé Ganry, Bruno Pereira. Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery. Pain, 2019, 160 (5), pp.1186-1195. ⟨10.1097/j.pain.0000000000001502⟩. ⟨hal-02325181⟩
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Gisèle Pickering, Isabelle Creveaux, Nicolas Macian, Bruno Pereira. Paracetamol and Pain Modulation by TRPV1, UGT2B15, SULT1A1 Genotypes: A Randomized Clinical Trial in Healthy Volunteers. Pain Medicine, 2019, ⟨10.1093/pm/pnz037⟩. ⟨hal-02325093⟩
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Jérémy Pinguet, Nicolas Kerckhove, Teuta Eljezi, Celine Lambert, Emmanuel Moreau, et al.. New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices. Talanta, 2019, 198, pp.377-389. ⟨10.1016/j.talanta.2019.01.115⟩. ⟨hal-02194877⟩
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https://hal.science/hal-02194877/file/S0039914019300670.pdf


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Teresa Rojas Rojas, Vincent Di Beo, Jessica Delorme, Tangui Barre, Philippe Mathurin, et al.. Lower HCV treatment uptake in women who have received opioid agonist therapy before and during the DAA era: The ANRS FANTASIO project. International Journal of Drug Policy, 2019, 72, pp.61-68. ⟨10.1016/j.drugpo.2019.05.013⟩. ⟨inserm-02272320⟩
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https://inserm.hal.science/inserm-02272320/file/1-s2.0-S0955395919301355-main.pdf

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Andréa Tarot, A. van Lander, Bruno Pereira, Virginie Guastella. Étude de la relation entre détresse et confusion mentale chez les patients en situation palliative (Relation entre détresse et confusion mentale en situation palliative). Médecine Palliative, 2019, 18 (6), pp.271-278. ⟨10.1016/j.medpal.2019.01.003⟩. ⟨hal-03119071⟩
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https://uca.hal.science/hal-03119071/file/S1636652219300534.pdf


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A. van Lander, A. Tarot, C. Savanovitch, B. Pereira, B. Vennat, et al.. Assessing the validity of the clinician-rated distress thermometer in palliative care. BMC Palliative Care, 2019, 18 (1), pp.81. ⟨10.1186/s12904-019-0466-x⟩. ⟨hal-02339687⟩
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2018

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David Balayssac, Bruno Pereira, Maxime Darfeuille, Pierre Cuq, Laurent Vernhet, et al.. Use of Psychotropic Medications and Illegal Drugs, and Related Consequences Among French Pharmacy Students – SCEP Study: A Nationwide Cross-Sectional Study. Frontiers in Pharmacology, 2018, 9, pp.725. ⟨10.3389/fphar.2018.00725⟩. ⟨hal-01858850⟩
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https://uca.hal.science/hal-01858850/file/pdf


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Chenaf Chouki, Jessica Delorme, Noémie Delage, Denis Ardid, Alain Eschalier, et al.. Prevalence of chronic pain with or without neuropathic characteristics in France using the capture-recapture method: a population-based study.. Pain, 2018, 159 (11), pp.2394-2402. ⟨10.1097/j.pain.0000000000001347⟩. ⟨hal-01926185⟩
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Jessica Delorme, Chouki Chenaf, Célian Bertin, Marie Riquelme, Alain Eschalier, et al.. Chronic Pain Opioid-Maintained Patients Receive Less Analgesic Opioid Prescriptions. Frontiers in Psychiatry, 2018, 9, pp.335. ⟨10.3389/fpsyt.2018.00335⟩. ⟨hal-04317238⟩
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https://hal.science/hal-04317238/file/fpsyt-09-00335.pdf


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Christian Dualé, Jean-Michel Cardot, Fabienne Joanny, Anna Trzeciakiewicz, Elodie Martin, et al.. An Advanced Formulation of a Magnesium Dietary Supplement Adapted for a Long-Term Use Supplementation Improves Magnesium Bioavailability: In Vitro and Clinical Comparative Studies. Biological Trace Element Research, 2018, 186 (1), pp.1-8. ⟨10.1007/s12011-018-1277-2⟩. ⟨hal-02460346⟩
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Virginie Guastella, Aurelien Mulliez, Andréa Tarot, Axelle van Lander. A « Wine Bar » at the palliative care unit: A different way of caring. Nursing and Palliative Care, 2018, 3 (4), pp.1-5. ⟨10.15761/NPC.1000192⟩. ⟨hal-02125551⟩
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N. Kerckhove, B. Pereira, S. Picard, H. Alchaar, R. Deleens, et al.. Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial. European Journal of Pain, 2018, 22 (7), pp.1321 – 1330. ⟨10.1002/ejp.1221⟩. ⟨hal-01844578⟩
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Gregoire Massoullié, Chenaf Chouki, Aurelien Mulliez, Patrick Rossignol, Sylvain Ploux, et al.. Effect of Optimization of Medical Treatment on Long-Term Survival of Patients With Heart Failure After Implantable Cardioverter Defibrillator and Cardiac Resynchronization Device Implantation (from the French National EGB Database). American Journal of Cardiology, 2018, 121 (6), pp.725-730. ⟨10.1016/j.amjcard.2017.12.013⟩. ⟨hal-01926282⟩
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Gisèle Pickering, Nicolas Macian, Noémie Delage, Pascale Picard, Jean-Michel Cardot, et al.. Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study. Drug Design, Development and Therapy, 2018, 12, pp.2485-2496. ⟨10.2147/DDDT.S162810⟩. ⟨hal-01870569⟩
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Laura Poupon, Sylvain Lamoine, Vanessa Pereira, David Barriere, Stéphane Lolignier, et al.. Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. Neuropharmacology, 2018, 140, pp.43-61. ⟨10.1016/j.neuropharm.2018.07.026⟩. ⟨hal-02065469⟩
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https://hal.science/hal-02065469/file/Poupon_Targeting_TREK-1_CombinedAAM.pdf


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Benoît Schreck, Nicolas Wagneur, Pascal Caillet, Marie Gérardin, Jennyfer Cholet, et al.. Cannabinoid hyperemesis syndrome: Review of the literature and of cases reported to the French addictovigilance network. Drug and Alcohol Dependence, 2018, 182, pp.27 – 32. ⟨10.1016/j.drugalcdep.2017.09.038⟩. ⟨hal-01682132⟩
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2017

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David Balayssac, Bruno Pereira, Julie Virot, Aurore Collin, David Alapini, et al.. Burnout, associated comorbidities and coping strategies in French community pharmacies—BOP study: A nationwide cross-sectional study. PLoS ONE, 2017, 12 (8), pp.e0182956. ⟨10.1371/journal.pone.0182956⟩. ⟨hal-01662459⟩
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David Balayssac, Bruno Pereira, Julie Virot, Celine Lambert, Aurore Collin, et al.. Work-related stress, associated comorbidities and stress causes in French community pharmacies: a nationwide cross-sectional study. PeerJ, 2017, 5, pp.e3973. ⟨10.7717/peerj.3973⟩. ⟨hal-01662581⟩
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https://uca.hal.science/hal-01662581/file/07ebdf76641948048df1db6ffe6193ebafc1.pdf


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Chouki Chenaf, Eric Chapuy, Frédéric Libert, Fabien Marchand, Christine Courteix, et al.. Agomelatine: a new opportunity to reduce neuropathic pain. Preclinical evidence.. Pain, 2017, 158 (1), pp.149 – 160. ⟨10.1097/j.pain.0000000000000738⟩. ⟨hal-01659567⟩
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Elisabeth Frauger, Liselotte Pochard, Quentin Boucherie, Adeline Giocanti, Cécile Chevallier, et al.. Dispositif pharmacoépidémiologique de surveillance des substances psychoactives : intérêts du programme national OPPIDUM du Réseau français d’addictovigilance. Thérapie, 2017, 72 (4), pp.491-501. ⟨10.1016/j.therap.2017.01.010⟩. ⟨hal-03620662⟩
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Marion Gougain, Moreau Alain, Rémy Boussageon, Gisèle Pickering, François Gueyffier. Effet antalgique aigu du paracétamol en soins primaires : des preuves incomplètes. Thérapie, 2017, 72 (5), pp.609 – 613. ⟨10.1016/j.therap.2017.02.004⟩. ⟨halshs-01866986⟩
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https://shs.hal.science/halshs-01866986/file/Gougain%202017%20-%20Paracetamol%20en%20soins%20primaires%20-%20version%20auteur.pdf


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Nicolas Kerckhove, Aurore Collin, Sakahlé Condé, Carine Chaleteix, Denis Pezet, et al.. Long-Term Effects, Pathophysiological Mechanisms, and Risk Factors of Chemotherapy-Induced Peripheral Neuropathies: A Comprehensive Literature Review. Frontiers in Pharmacology, 2017, 8, ⟨10.3389/fphar.2017.00086⟩. ⟨hal-01682157⟩
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Nicolas Kerckhove, Bruno Pereira, Denis Pezet, David Balayssac. Clinical assessment of new antineuropathic strategies for chemotherapy-induced peripheral neuropathy: pain should not be the principal endpoint. Pain, 2017, 158 (1), pp.180-182. ⟨10.1097/j.pain.0000000000000743⟩. ⟨hal-01607744⟩
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Gisèle Pickering, Elodie Martin, Florence Tiberghien, Claire Delorme, Gérard Mick. Localized neuropathic pain: an expert consensus on local treatments. Drug Design, Development and Therapy, 2017, 11, pp.2709-2718. ⟨10.2147/DDDT.S142630⟩. ⟨hal-01722921⟩
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https://univ-lyon1.hal.science/hal-01722921/file/Localized%20neuropathic%20pain%20an%20expert%20consensus%20on%20local%20treatments.pdf


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Gisèle Pickering, Véronique Morel. Memantine for the treatment of general neuropathic pain: a narrative review. Fundamental & Clinical Pharmacology, 2017, ⟨10.1111/fcp.12316⟩. ⟨hal-01662479⟩
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Gisèle Pickering, Fiammetta Monacelli, Juan Manuel Pérez-Castejón Garrote, Hirondina Guarda, Luis Batalha, et al.. Reliability Study in Five Languages of the Translation of the Pain Observational Scale Algoplus. Pain Medicine, 2017, ⟨10.1093/pm/pnw356⟩. ⟨hal-01662587⟩
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2016

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Nicolas Authier, Philippe Binder, Julie Dupouy, Paolo Di Patrizio, Gaetan Gentile, et al.. Study protocol of the ESUB-MG cluster randomized trial: a pragmatic trial assessing the implementation of urine drug screening in general practice for buprenorphine maintained patients. BMC Family Practice, 2016, 17 (1), pp.887-896. ⟨10.1186/s12875-016-0413-3⟩. ⟨hal-02100643⟩
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https://hal.univ-lorraine.fr/hal-02100643/file/12875_2016_Article_413.pdf


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Jessica Delorme, Chouki Chenaf, Jean-Luc Kabore, Bruno Pereira, Aurélien Mulliez, et al.. Incidence of high dosage buprenorphine and methadone shopping behavior in a retrospective cohort of opioid-maintained patients in France. Drug and Alcohol Dependence, 2016, 162, pp.99-106. ⟨10.1016/j.drugalcdep.2016.02.035⟩. ⟨hal-02167759⟩
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Mélanie Kernisant, Jessica Delorme, Jean-Luc Kabore, Georges Brousse, Catherine Laporte, et al.. Diminution de la prévalence du docteur shopping de la buprénorphine entre 2004 et 2014 en France. La Presse Médicale, 2016, 45 (12), pp.e369-e375. ⟨10.1016/j.lpm.2016.10.011⟩. ⟨hal-02167767⟩
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Gregoire Massoullie, Jerome Wintzer-Wehekind, Chouki Chenaf, Aurelien Mulliez, Bruno Pereira, et al.. Prognosis and management of myocardial infarction: Comparisons between the French FAST-MI 2010 registry and the French public health database. Archives of cardiovascular diseases, 2016, 109 (5), pp.303-310. ⟨10.1016/j.acvd.2016.01.012⟩. ⟨hal-01515297⟩
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https://hal.science/hal-01515297/file/1-s2.0-S1875213616300614-main.pdf


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2015

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Nicolas Bourdel, João Alves, Gisèle Pickering, Irina Ramilo, Horace Roman, et al.. Systematic review of endometriosis pain assessment: how to choose a scale?. Human Reproduction Update, 2015, 21 (1), pp.136-152. ⟨10.1093/humupd/dmu046⟩. ⟨hal-02317130⟩
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Gisèle Pickering, Adrian Kastler, Nicolas Macian, Bruno Pereira, Romain Valabregue, et al.. The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial. Drug Design, Development and Therapy, 2015, 9, pp.3853-3862. ⟨10.2147/DDDT.S81004⟩. ⟨hal-01214449⟩
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https://hal.sorbonne-universite.fr/hal-01214449/file/DDDT-81004-the-brain-signature-of-paracetamol-in-healthy-volunteers--a-_072315.pdf


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2014

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Nicolas Kerckhove, Christophe Mallet, Amaury François, Mathieu Boudes, Jean Chemin, et al.. Cav3.2 calcium channels: the key protagonist of the supraspinal effect of paracetamol. Pain, 2014, 155 (4), pp.764-772. ⟨10.1016/j.pain.2014.01.015⟩. ⟨hal-02356344⟩
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https://hal.science/hal-02356344/file/Kerckhove%20et%20al%20%282014%29%20Pain%20-%20Paracetamol%20and%20Cav3.2.pdf


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Gisèle Pickering, Véronique Morel, Dominique Joly, Christine Villatte, Delphine Roux, et al.. Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial. Trials, 2014, 15, pp.331. ⟨10.1186/1745-6215-15-331⟩. ⟨inserm-01122386⟩
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https://inserm.hal.science/inserm-01122386/file/1745-6215-15-331.pdf


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2013

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Amaury François, Nicolas Kerckhove, Mathieu Meleine, Abdelkrim Alloui, Christian Barrère, et al.. State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects. Pain, 2013, 154 (2), pp.283-293. ⟨10.1016/j.pain.2012.10.023⟩. ⟨hal-02370536⟩
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2012

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Estelle Pujos-Guillot, Gisèle Pickering, Bernard Lyan, Gilles Ducheix, Marion Brandolini-Bunlon, et al.. Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids. AGE, 2012, 34 (1), pp.181-193. ⟨10.1007/s11357-011-9218-4⟩. ⟨hal-01190472⟩
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https://hal.science/hal-01190472/file/2013_Pujos-Guillot_age_%7B2A068988-311D-4933-8D08-03D0288A4EC3%7D.pdf


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2011

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Juliette Descoeur, Vanessa Pereira, Anne Pizzoccaro, Amaury François, Bing Ling, et al.. Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Molecular Medicine, 2011, 3 (5), pp.266-278. ⟨10.1002/emmm.201100134⟩. ⟨hal-02370551⟩
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https://hal.science/hal-02370551/file/emmm.201100134.pdf


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Virginie Guastella, Gérard Mick, Christophe Soriano, Laurent Vallet, Georges Escande, et al.. A prospective study of neuropathic pain induced by thoracotomy: Incidence, clinical description, and diagnosis. Pain, 2011, 152, pp.74 – 81. ⟨10.1016/j.pain.2010.09.004⟩. ⟨hal-04127021⟩
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https://hal.science/hal-04127021/file/PAIN7728.pdf


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Gisèle Pickering, E. Schneider, Isabelle Papet, Estelle Pujos-Guillot, B. Pereira, et al.. Acetaminophen metabolism after major surgery: a greater challenge with increasing age. Clinical Pharmacology and Therapeutics, 2011, 90 (5), pp.707 – 711. ⟨10.1038/clpt.2011.176⟩. ⟨hal-02644818⟩
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Axelle Van Lander, Céline Deveuve-Muriol, Bruno Pereira, Claire Valour, Christophe Rutowicz, et al.. Entretiens psychologiques en soins palliatifs. Revue internationale de soins palliatifs, 2011, 26 (3), pp.269-275. ⟨10.3917/inka.113.0269⟩. ⟨hal-04666287⟩
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https://uca.hal.science/hal-04666287/file/Entretiens_psychologiques_en_soins_palliatifs_caract%C3%A9ristiques_des_patients_sp%C3%A9cificit%C3%A9s_des_suivis_.pdf


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Conference papers

2024

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Fabien Wauquier, Line Boutin-Wittrant, Line Pourtau, David Gaudout, Benjamin Moras, et al.. Les métabolites sériques humains circulants dérivés de la consommation d’un extrait de safran (Safr’InsideTM) protègent les neurones du stress oxydatif : considérations pour les troubles dépressifs. Journées Françaises de Nutrition, Société Française de Nutrition, Dec 2024, Strasbourg, France. ⟨hal-04698791⟩
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2023

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Gaïa Lépine, Marie Tremblay-Franco, François Mariotti, Jérémie David, Marion Courrent, et al.. Exploring the impact of plant protein vs. animal protein-rich diets in men at cardiometabolic risk: insights from plasma metabolome signatures. 3rd Nordic Metabolomics Conference, Oct 2023, Trondheim, Norway. ⟨hal-04354565⟩
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2021

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Ophélie Uriot, Elora Fournier, Frédérique Lajoie, Nicolas Kerckhove, Julien Scanzi, et al.. Development of an in vitro model of dysbiotic colonic conditions of IBS-D patients. 12. International Symposium on Gut Microbiology, INRAE ; Rowett Institute UK, Oct 2021, En ligne, France. ⟨hal-03402422⟩
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Aurélien Viret, Asma Bourafai-Aziez, Fabien F. Wauquier, Line Boutin-Wittrant, Glwadys Charpentier, et al.. Metabolic profiling strategy for determination of the absorption peak of artichoke leaf extract in human enriched serum. 14ème journées scientifiques du RFMF, Nov 2021, Aussois, France. ⟨hal-03529874⟩
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Book sections

2018

ref_biblio
Nicolas Authier, Bénédicte Eschalier, Chouki Chenaf, Marie Zenut, Christophe Mallet, et al.. Traitements de la douleur, Approche pharmacologique. Traité de Médecine (5ème édition), TDM, pp.S10-P01-C11, 2018, 9782901094012. ⟨hal-04273871⟩
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Poster communications

2024

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Laurent Mosoni, Cécile Gladine, Claire Sulmont-Rossé, Didier Remond, Matthieu Maillot, et al.. Explorer la variabilité interindividuelle de la réponse à l’alimentation dans une population âgée non fragile vivant à domicile : les projets DBSage et MétabotypAGE. Journée scientifique du CIR3, Oct 2024, Clermont-Ferrand, France. ⟨hal-04793148⟩
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2023

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Gaïa Lépine, Marie Tremblay-Franco, François Mariotti, Jérémie David, Marion Courrent, et al.. Plasma metabolomics reveal metabolite changes compatible with improved metabolic health after 1-month of a plant-rich dietary intervention. NuGOweek 2023, Sep 2023, Senigallia, Italy. ⟨hal-04211898⟩
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Armel Soubeiga, Jessem Ettaghouti, Violaine Antoine, Alice Corteval, Nicolas Kerckhove, et al.. Clustering de séries chronologiques de patients souffrant de douleurs chroniques. Extraction et Gestion des Connaissances (EGC) – 2023, Jan 2023, Lyon, France. . ⟨hal-04063254⟩
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Ophélie Uriot, Sylvain Denis, Nicolas Kerckhove, Julien Scanzi, Lucie Etienne-Mesmin, et al.. Development of a new in vitro model of inflammatory bowel syndrome gut microbiome. 10th FEMS Congress of European Microbiologists, Jul 2023, Hambourg (Neversdorf), Germany. ⟨hal-04215089⟩
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2022

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Gaïa Lépine, François Mariotti, Marie-Anne Verny, Laetitia Guerin-Deremaux, Catherine Lefranc-Millot, et al.. Effet d’une alimentation plus ou moins végétalisée sur la santé cardio-métabolique : un essai clinique randomisé de 2 mois en croisé avec un haut niveau de contrôle nutritionnel. Journées Francophones de la Nutrition 2022, Nov 2022, Toulouse, France. ⟨hal-03891170⟩
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2021

ref_biblio
Ophélie Uriot, Elora Fournier, Frédérique Lajoie, N. Kerckhove, Julien Scanzi, et al.. Development of an in vitro model of dysbiotic colonic conditions of IBS-D patients. 12. International symposium on Gut Microbiology, Oct 2021, Clermont-Ferrand (online), France. ⟨hal-03739752⟩
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2019

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Celian Bertin, Jessica Delorme, Alain Eschalier, Chouki Chenaf, Nicolas Authier. Assessment of codeine use disorder weak signals on social networks. Congrès Albatros, Jun 2019, PARIS, France. ⟨hal-02363869⟩
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Celian Bertin, Jessica Delorme, Alain Eschalier, Chouki Chenaf, Nicolas Authier. L’analyse des réseaux sociaux comme nouvel outil de pharmacosurveillance : à propos de la codéine. Congrès ATHS, Oct 2019, BIARRITZ, France. ⟨hal-02363843⟩
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2017

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P. Sirvent, M. Bargetto, V. Chavanelle, Nicolas Macian, Sylvia Boulliau, et al.. Phase I clinical trial to evaluate TOTUM-63, a botanical complex for managing prediabetes. 77th Scientific Sessions of American Diabetes Association, Jun 2017, San Diego, United States. ⟨hal-01682304⟩
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https://uca.hal.science/hal-01682304/file/Poster-ADA-2017-3.pdf


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Reports

2020

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Hélène Bastuji, Sophie Baudic, Julie Berbis, Didier Bouhassira, Morgiane Bridou, et al.. Fibromyalgie. [Rapport de recherche] Inserm (dir.). Fibromyalgie. Collection Expertise collective. Rapport. Montrouge : EDP Sciences, 2020., Institut national de la santé et de la recherche médicale (INSERM). 2020, Paris : Inserm : Éditions EDP Sciences (ISSN : 0990-7440) / XIV-883 p. ⟨inserm-03384916⟩
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https://inserm.hal.science/inserm-03384916/file/Exp-coll_Fibromyalgie_rapport.pdf


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Theses

2013

ref_biblio
Nicolas Kerckhove. Implication des canaux Cav3.2 dans l’effet antalgique du paracétamol et dans la douleur inflammatoire. Pharmacologie. Université d’Auvergne – Clermont-Ferrand I, 2013. Français. ⟨NNT : 2013CLF1PP04⟩. ⟨tel-01165233⟩
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