Philippe LUCCARINI (EN)
UFR Odontologie, 2 rue de Braga , 63100 Clermont-Ferrand
IUT Dépt Génie Biologique, 5 avenue Blaise-Pascal – TSA 90110 – 63178 Aubière Cedex
Pr. Philippe LUCCARINI
Professor HDR
Team TPM – Pathophysiology of migraine axis, Team TPM – Therapeutic Targets and Technological Innovations Axis, Team TPM -Technical Advances, Team Trigeminal Pain and Migraine
philippe.luccarini@-Code to remove to avoid SPAM-uca.fr
+33 4 7317 73 17, room 243
Student :
Biography:
My pre-clinical research work, on rats and mice, first focused on the characterization and modulation of nociceptive activities within the trigeminal sensory complex, the first central relay of information coming from the cephalic sphere. I subsequently focused on the pathophysiology of migraine and developed in this context a new model of migraine in rats. This model supported work aimed at identifying new therapeutic targets such as the role played by astrocytes and D-Serine. Currently my work concerns the identification of potential anti-migraine treatments and in particular the interest of dual enkephalinase inhibitors and/or delta opioid receptor agonists.
Approaches/Techniques:
My work is based on in vivo electrophysiological (extracellular single unit recordings), behavioral (rat mouse), pharmacological and immunohistochemical approaches.
Functions:
P.U. Neurosciences
Teachings:
Carried out within the IUT of Clermont Auvergne, covering animal and human physiology, neuroscience and animal experimentation.
Responsibilities:
- Responsible for User Establishment 0123 for animal experimentation.
- Responsible for the animal welfare structure of the Estaing site laboratory.
- Educational manager of training for applicators of procedures and experimental surgery.
- Head of the Auvergne Brain Week committee.
- President of the AuverBrain association (popularization of neuroscience for the general public).
- CESPAU/Neuro-Dol correspondent for general public events.
- INSERM referent for the management and prevention of media risk relating to animal experimentation on Clermont sites.
Collaborations:
Cifre Convention with Pharmaleads (Paris)
Image:
HAL Publications
Journal articles
2024
- ref_biblio
- Jeanne Rossignol, Tanja Ouimet, Hervé Poras, Radhouane Dallel, Philippe Luccarini. Synergistic effect of combining dual enkephalinase inhibitor PL37 and sumatriptan in a preclinical model of migraine. Headache: The Journal of Head and Face Pain, 2024, ⟨10.1111/head.14681⟩. ⟨hal-04473327⟩
- Accès au bibtex
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- ref_biblio
- Jeanne Rossignol, Tanja Ouimet, Hervé Poras, Radhouane Dallel, Philippe Luccarini. Synergistic effect of combining dual enkephalinase inhibitor PL37 and sumatriptan in a preclinical model of migraine. Headache: The Journal of Head and Face Pain, 2024, ⟨10.1111/head.14681⟩. ⟨hal-04475446⟩
- Accès au bibtex
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2021
- ref_biblio
- F. Gabrielli, M. Megemont, R. Dallel, P. Luccarini, L. Monconduit. Model-based signal processing enables bidirectional inferring between local field potential and spikes evoked by noxious stimulation. Brain Research Bulletin, 2021, 174, pp.212-219. ⟨10.1016/j.brainresbull.2021.05.025⟩. ⟨hal-04335695⟩
- Accès au bibtex
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2017
- ref_biblio
- Radhouane Dallel, Amélie Descheemaeker, Philippe Luccarini. Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: A model for migraine progression.. Cephalalgia, 2017, ⟨10.1177/0333102417714032⟩. ⟨hal-01680712⟩
- Accès au bibtex
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- ref_biblio
- José Maria Ramos Flores, Laurent Devoize, Amélie Descheemaeker, Jean-Louis Molat, Philippe Luccarini, et al.. The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn. Neuroscience, 2017, ⟨10.1016/j.neuroscience.2016.12.028⟩. ⟨inserm-01458345⟩
- Accès au texte intégral et bibtex
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2015
- ref_biblio
- Khaled Abdallah, Lénaïc Monconduit, Alain Artola, Philippe Luccarini, Radhouane Dallel. GABAAergic inhibition or dopamine denervation of the A11 hypothalamic nucleus induces trigeminal analgesia. Pain, 2015, 156 (4), pp.644 – 655. ⟨10.1097/j.pain.0000000000000091⟩. ⟨hal-01836230⟩
- Accès au bibtex
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2014
- ref_biblio
- R. Chebbi, N. Boyer, L. Monconduit, A. Artola, P. Luccarini, et al.. The nucleus raphe magnus OFF-cells are involved in diffuse noxious inhibitory controls. Experimental Neurology, 2014, 256, pp.39 – 45. ⟨10.1016/j.expneurol.2014.03.006⟩. ⟨hal-01836247⟩
- Accès au bibtex
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2013
- ref_biblio
- Khaled Abdallah, Alain Artola, Lã©naic Monconduit, Radhouane Dallel, Philippe Luccarini, et al.. Correction: Bilateral Descending Hypothalamic Projections to the Spinal Trigeminal Nucleus Caudalis in Rats. PLoS ONE, 2013, 8 (9), ⟨10.1371/annotation/7c794f90-1101-4196-8b10-4e3e320a7aac⟩. ⟨hal-01836263⟩
- Accès au bibtex
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- ref_biblio
- Khaled Abdallah, Alain Artola, Lénaïc Monconduit, Radhouane Dallel, Philippe Luccarini, et al.. Bilateral Descending Hypothalamic Projections to the Spinal Trigeminal Nucleus Caudalis in Rats. PLoS ONE, 2013, 8 (8), ⟨10.1371/journal.pone.0073022⟩. ⟨hal-01836269⟩
- Accès au bibtex
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- ref_biblio
- A. Normandin, P. Luccarini, L. Molat, L. Gendron, R. Dallel. Spinal and Opioids Inhibit Both Thermal and Mechanical Pain in Rats. Journal of Neuroscience, 2013, 33 (28), pp.11703 – 11714. ⟨10.1523/JNEUROSCI.1631-13.2013⟩. ⟨hal-01836258⟩
- Accès au bibtex
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2011
- ref_biblio
- Olivier Lapirot, Céline Melin, Alice Modolo, Charline Nicolas, Yassine Messaoudi, et al.. Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn. Pain, 2011, 152 (8), pp.1821 – 1831. ⟨10.1016/j.pain.2011.03.030⟩. ⟨hal-01836275⟩
- Accès au bibtex
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2006
- ref_biblio
- Jerome Coste, D L Voisin, P Luccarini, R Dallel. A Role For Wind-Up in Trigeminal Sensory Processing: Intensity Coding of Nociceptive Stimuli in the Rat. Cephalalgia, 2006, 28 (6), pp.631-639. ⟨10.1111/j.1468-2982.2008.01568.x⟩. ⟨hal-01543129⟩
- Accès au texte intégral et bibtex
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- ref_biblio
- Philippe Luccarini, Anne Childeric, Anne-Marie Gaydier, Daniel Voisin, Radhouane Dallel. The Orofacial Formalin Test in the Mouse: A Behavioral Model for Studying Physiology and Modulation of Trigeminal Nociception. Journal of Pain, 2006, 7, pp.908 – 914. ⟨10.1016/j.jpain.2006.04.010⟩. ⟨hal-04468654⟩
- Accès au bibtex
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2004
- ref_biblio
- Philippe Luccarini, Laurent Perrier, Céline Dégoulange, Anne-Marie Gaydier, Radhouane Dallel. Synergistic Antinociceptive Effect of Amitriptyline and Morphine in the Rat Orofacial Formalin Test. Anesthesiology, 2004, 100 (3), pp.690 – 696. ⟨10.1097/00000542-200403000-00033⟩. ⟨hal-01836710⟩
- Accès au bibtex
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- ref_biblio
- Alain Woda, Olivier Blanc, Daniel L. Voisin, Jerome Coste, Jean-Louis Molat, et al.. Bidirectional modulation of windup by NMDA receptors in the rat spinal trigeminal nucleus. European Journal of Neuroscience, 2004, 19 (8), pp.2009-2016. ⟨10.1111/j.0953-816X.2004.03328.x⟩. ⟨hal-01543022⟩
- Accès au texte intégral et bibtex
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2003
- ref_biblio
- Philippe Luccarini, Melaine Henry, Pedro Alvarez, Anne-Marie Gaydier, Radhouane Dallel. Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain. Naunyn-Schmiedeberg’s Archives of Pharmacology, 2003, 368 (4), pp.320 – 323. ⟨10.1007/s00210-003-0799-z⟩. ⟨hal-01836288⟩
- Accès au bibtex
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2001
- ref_biblio
- P Luccarini, B.J Sessle, A Woda. SUPERFICIAL AND DEEP CONVERGENT NOCICEPTIVE NEURONS ARE DIFFERENTIALLY AFFECTED BY N-METHYL-D-ASPARTATE APPLIED ON THE BRAINSTEM SURFACE OF THE RAT MEDULLARY DORSAL HORN. Neuroscience, 2001, 107 (2), pp.311-316. ⟨10.1016/s0306-4522(01)00360-8⟩. ⟨hal-01836885⟩
- Accès au bibtex
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- ref_biblio
- A Woda, J.-L Molat, P Luccarini. LOW DOSES OF N-METHYL-D-ASPARTATE ANTAGONISTS IN SUPERFICIAL LAMINAE OF MEDULLA OBLONGATA FACILITATE WIND-UP OF CONVERGENT NEURONES. Neuroscience, 2001, 107 (2), pp.317-327. ⟨10.1016/s0306-4522(01)00359-1⟩. ⟨hal-01836873⟩
- Accès au bibtex
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1999
- ref_biblio
- Radhouane Dallel, Christian Dualé, Philippe Luccarini, Jean‐louis Molat. Stimulus-function, wind-up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis. European Journal of Neuroscience, 1999, 11 (1), pp.31 – 40. ⟨10.1046/j.1460-9568.1999.00404.x⟩. ⟨hal-01836891⟩
- Accès au bibtex
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1996
- ref_biblio
- Christian Dualé, Philippe Luccarini, Rémi Cadet, Alain Woda. Effects of Morphine Microinjections into the Trigeminal Sensory Complex on the Formalin Test in the Rat. Experimental Neurology, 1996, 142 (2), pp.331-339. ⟨10.1006/exnr.1996.0202⟩. ⟨hal-01836912⟩
- Accès au bibtex
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1995
- ref_biblio
- P Luccarini, R Cadet, M. Saade, A Woda. Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.. NeuroReport, 1995, pp.365-8. ⟨hal-01836999⟩
- Accès au bibtex
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1993
- ref_biblio
- O Pompeiano, P Luccarini, Y Gahery, G. Blanchet. Somatotopical effects of local microinjection of GABAergic agents in Deiters nucleus on the posturokinetic responses to cortical stimulation.. Journal of Vestibular Research, 1993, pp.391-407. ⟨hal-01837025⟩
- Accès au bibtex
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1992
- ref_biblio
- P Luccarini, Y Gahery, G. Blanchet, O Pompeiano. GABA receptors in Deiters nucleus modulate posturokinetic responses to cortical stimulation in the cat.. Archives Italiennes de Biologie, 1992, pp.127-54. ⟨hal-01836995⟩
- Accès au bibtex
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1990
- ref_biblio
- P Luccarini, Y Gahery, O Pompeiano. Cholinoceptive pontine reticular structures modify the postural adjustments during the limb movements induced by cortical stimulation.. Archives Italiennes de Biologie, 1990, pp.19-45. ⟨hal-01837032⟩
- Accès au bibtex
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- ref_biblio
- P Luccarini, Y Gahery, O Pompeiano. Injection of a cholinergic agonist in the dorsolateral pontine tegmentum of cats affects the posturokinetic responses to cortical stimulation. Neuroscience Letters, 1990, 114, pp.75 – 81. ⟨hal-01840727⟩
- Accès au bibtex
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Conference papers
2023
- ref_biblio
- Jeanne Rossignol, Hervé Poras, T. Ouimet, Michel Wurm, Radhouane Dallel, et al.. Dual ENKephalinase Inhibitor (DENKI) PL37 as a potential novel treatment of migraine-like symptom. XVIIIeme Symposion du reseau Inserm de recherche sur la douleur, Mar 2023, Montpellier, France. ⟨hal-04605906⟩
- Accès au bibtex
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2019
- ref_biblio
- Amélie Descheemaeker, Hervé Poras, T. Ouimet, P. Luccarini, Michel Wurm, et al.. Dual ENKephalinase Inhibitor (DENKI) PL37: A possible new class of migraine therapeutics. XIXth International Headache Congress, Sep 2019, Dublin, Ireland. ⟨hal-04605885⟩
- Accès au bibtex
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- ref_biblio
- P. Luccarini, Marine Megemont, Amélie Descheemaeker, Radhouane Dallel, L. Monconduit. Astrocytes contribute to the trigeminal central sensitization and cephalic cutaneous hypersensitivity in rat model of chronic migraine.. NeuroFrance 2019 Congress, 23-24 mai 2019, Marseille (France)., Société des neurosciences, May 2019, MARSEILLE, France. ⟨hal-04605880⟩
- Accès au bibtex
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- ref_biblio
- Marine Megemont, Amélie Descheemaeker, Radhouane Dallel, L. Monconduit, P. Luccarini. Astrocytes contribute to the trigeminal central sensitization and cephalic cutaneous hypersensitivity in rat model of chronic migraine.. 15th Symposium de la Recherche du Réseau Douleur, Mar 2019, Paris, France. ⟨hal-04605879⟩
- Accès au bibtex
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2018
- ref_biblio
- Amélie Descheemaeker, Hervé Poras, P. Luccarini, Michel Wurm, Radhouane Dallel. Dual ENKephalinase Inhibitor (DENKI) PL37: A possible new class of migraine therapeutics.. 17th World Congress on Pain., Sep 2018, Boston (MA), United States. ⟨hal-04605849⟩
- Accès au bibtex
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- ref_biblio
- Marine Megemont, Amélie Descheemaeker, Radhouane Dallel, Lenaic Monconduit, P. Luccarini. Astrocytes contribute to the trigeminal central sensitization and cephalic cutaneous hypersensitivity in rat model of chronic migraine.. 12th European Headache Federation Congress, Sep 2018, Firenze (Florence), Italy. ⟨hal-04605851⟩
- Accès au bibtex
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2014
- ref_biblio
- Florian Jacquot, Radhouane Dallel, P. Luccarini, Alain Artola. Medial amygdala is involved in anxiety-like behavior induced by repeated dural nociception in rats. 9th FENS Forum of Neuroscience, Jul 2014, Milan, Italy. ⟨hal-04605886⟩
- Accès au bibtex
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2012
- ref_biblio
- Khaled Abdallah, Amandine Cavaroc, S. Tronche, Amandine Laurans, Radhouane Dallel, et al.. Neurochemical organization of descending hypothalamic projections to the medullay dorsal horn. 8ème FENS forum of Neuroscience, Jul 2012, Barcelonna, Spain. ⟨hal-04605890⟩
- Accès au bibtex
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- ref_biblio
- A. Normandin, P. Luccarini, J.-L Molat, Radhouane Dallel, Louis Gendron. Spinal mu opioid receptors regulate both heat and mechanical pain in rats.. The International Narcotics Research Conference 2012, Jul 2012, Kansas City (US), United States. ⟨hal-04605888⟩
- Accès au bibtex
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2010
- ref_biblio
- P. Luccarini, Olivier Lapirot, Alice Modolo, Claire Villemain, Charline Nicolas, et al.. Superficial medullary dorsal horn dopamine D2 receptors modulate mainly trigeminal C-fiber nociceptive transmission. 13th World Congress on Pain, IASP, Aug 2010, Montréal (Québec), Canada. ⟨hal-04605893⟩
- Accès au bibtex
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2008
- ref_biblio
- Raja Chebbi, Olivier Lapirot, Radhouane Dallel, P. Luccarini. Involvement of the nucleus raphe magnus in Diffuse Noxious Inhibitory Controls (DNIC) in the rat. 12th World Congress on pain, IASP, Aug 2008, Glasgow (Ecosse), United Kingdom. ⟨hal-04605901⟩
- Accès au bibtex
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Book sections
2002
- ref_biblio
- P. Luccarini, A Woda. NMDA-dependent inhibition of wind-up in
Festschrift Kjell Hole 70 years. Pain and Brain. Festschrift Kjell Hole 70 years. Pain and Brain, NMDA-dependent inhibition of wind-up, Berge eds, pp.56, 2002. ⟨hal-04468841⟩ - Accès au bibtex
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2001
- ref_biblio
- P. Luccarini, R. Dallel. Nouvelles données dans l’approche électrophysiologique des mécanismes neuronaux de la nociception oro-faciale.. université de Saint Etienne. Actes du Colloque National de la Recherche en IUT 2001, tome 1, pp.165, 2001. ⟨hal-04468867⟩
- Accès au bibtex
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1992
- ref_biblio
- P. Luccarini, Y. Gahery, O. Pompeiano. Modulation of the early postural adjustments associated with a limb movement after microinjection of GABAergic agent in the Deiters nucleus. Woollacott M., Horak F. (Eds.). Posture and Gait: Control Mechanisms, 1, pp.14, 1992. ⟨hal-04468888⟩
- Accès au bibtex
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1990
- ref_biblio
- P. Luccarini, Y. Gahery, O. Pompeiano. Cholinergic mechanisms responsible for the gain regulation of the postural adjustments during the cortically induced limb movement. T. Brandt, W. Paulus, W. Bles, M. Dieterich, S. Krafczyk and A. Straube Editors. Disorders of Posture and Gait., Georg Thieme Verlag Stuttgart. New York, pp.346, 1990. ⟨hal-04468904⟩
- Accès au bibtex
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Habilitation à diriger des recherches
1999
- ref_biblio
- P Luccarini. TITRES et TRAVAUX. Sciences du Vivant [q-bio]. Université d’auvergne, 1999. ⟨tel-04355204⟩
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Theses
1991
- ref_biblio
- Philippe Luccarini. Analyse des accompagnements posturaux associés à la flexion d’une patte chez le chat : modulation à partir du tegmentum pontique dorsolatéral et du noyau vestibulaire latéral. Neurobiologie. Université Aix Marseille 1, 1991. Français. ⟨NNT : ⟩. ⟨tel-04473601⟩
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