Philippe LUCCARINI (EN)

UFR Odontologie, 2 rue de Braga , 63100 Clermont-Ferrand
IUT Dépt Génie Biologique, 5 avenue Blaise-Pascal – TSA 90110 – 63178 Aubière Cedex

Pr. Philippe LUCCARINI

Professor HDR
Team TPM – Pathophysiology of migraine axis, Team TPM – Therapeutic Targets and Technological Innovations Axis, Team TPM -Technical Advances, Team Trigeminal Pain and Migraine

philippe.luccarini@-Code to remove to avoid SPAM-uca.fr
+33 4 7317 73 17, room 243

Student :

Anais LEGRAND

Biography:

My pre-clinical research work, on rats and mice, first focused on the characterization and modulation of nociceptive activities within the trigeminal sensory complex, the first central relay of information coming from the cephalic sphere. I subsequently focused on the pathophysiology of migraine and developed in this context a new model of migraine in rats. This model supported work aimed at identifying new therapeutic targets such as the role played by astrocytes and D-Serine. Currently my work concerns the identification of potential anti-migraine treatments and in particular the interest of dual enkephalinase inhibitors and/or delta opioid receptor agonists.

Approaches/Techniques:

My work is based on in vivo electrophysiological (extracellular single unit recordings), behavioral (rat mouse), pharmacological and immunohistochemical approaches.

Functions:

P.U. Neurosciences

Teachings:

Carried out within the IUT of Clermont Auvergne, covering animal and human physiology, neuroscience and animal experimentation.

Responsibilities:

Responsible for User Establishment 0123 for animal experimentation.
Responsible for the animal welfare structure of the Estaing site laboratory.
Educational manager of training for applicators of procedures and experimental surgery.
Head of the Auvergne Brain Week committee.
President of the AuverBrain association (popularization of neuroscience for the general public).
CESPAU/Neuro-Dol correspondent for general public events.
INSERM referent for the management and prevention of media risk relating to animal experimentation on Clermont sites.

Collaborations:

Cifre Convention with Pharmaleads (Paris)

Image:

HAL Publications

Journal articles

2025

ref_biblio: Manon Dussol, Gisela da Silva Borges, Claudie Beaulieu, Hadir Ghorbel, Amélie Descheemaeker, et al.. Contribution of peripheral and central delta opioid receptors in the relief of migraine‐like headache in female and male rats. British Journal of Pharmacology, 2025, 182 (18), pp.4380-4399. ⟨10.1111/bph.70098⟩. ⟨hal-05281543⟩
Accès au bibtex

2024

ref_biblio: Jeanne Rossignol, Tanja Ouimet, Hervé Poras, Radhouane Dallel, Philippe Luccarini. Synergistic effect of combining dual enkephalinase inhibitor PL37 and sumatriptan in a preclinical model of migraine. Headache: The Journal of Head and Face Pain, 2024, ⟨10.1111/head.14681⟩. ⟨hal-04473327⟩
Accès au bibtex

2022

ref_biblio: Amélie Descheemaeker, Hervé Poras, Michel Wurm, Philippe Luccarini, Tanja Ouimet, et al.. Dual enkephalinase inhibitor PL37 as a potential novel treatment of migraine: evidence from a rat model. Brain – A Journal of Neurology , 2022, 145 (8), ⟨10.1093/brain/awac139⟩. ⟨hal-03643577⟩
Accès au texte intégral et bibtex

2021

ref_biblio: François Gabrielli, M. Megemont, R. Dallel, P. Luccarini, L. Monconduit. Model-based signal processing enables bidirectional inferring between local field potential and spikes evoked by noxious stimulation. Brain Research Bulletin, 2021, 174, pp.212-219. ⟨10.1016/j.brainresbull.2021.05.025⟩. ⟨hal-04338701⟩
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2017

ref_biblio: Radhouane Dallel, Amélie Descheemaeker, Philippe Luccarini. Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: A model for migraine progression.. Cephalalgia, 2017, ⟨10.1177/0333102417714032⟩. ⟨hal-01680712⟩
Accès au bibtex

ref_biblio: José Maria Ramos Flores, Laurent Devoize, Amélie Descheemaeker, Jean-Louis Molat, Philippe Luccarini, et al.. The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn. Neuroscience, 2017, ⟨10.1016/j.neuroscience.2016.12.028⟩. ⟨inserm-01458345⟩
Accès au texte intégral et bibtex

2015

ref_biblio: Khaled Abdallah, Lénaïc Monconduit, Alain Artola, Philippe Luccarini, Radhouane Dallel. GABAAergic inhibition or dopamine denervation of the A11 hypothalamic nucleus induces trigeminal analgesia. Pain, 2015, 156 (4), pp.644 – 655. ⟨10.1097/j.pain.0000000000000091⟩. ⟨hal-01836230⟩
Accès au bibtex

2014

ref_biblio: R. Chebbi, N. Boyer, L. Monconduit, A. Artola, P. Luccarini, et al.. The nucleus raphe magnus OFF-cells are involved in diffuse noxious inhibitory controls. Experimental Neurology, 2014, 256, pp.39 – 45. ⟨10.1016/j.expneurol.2014.03.006⟩. ⟨hal-01836247⟩
Accès au bibtex

2013

ref_biblio: Khaled Abdallah, Alain Artola, Lénaïc Monconduit, Radhouane Dallel, Philippe Luccarini, et al.. Bilateral Descending Hypothalamic Projections to the Spinal Trigeminal Nucleus Caudalis in Rats. PLoS ONE, 2013, 8 (8), ⟨10.1371/journal.pone.0073022⟩. ⟨hal-01836269⟩
Accès au bibtex

ref_biblio: Khaled Abdallah, Alain Artola, Lã©naic Monconduit, Radhouane Dallel, Philippe Luccarini, et al.. Correction: Bilateral Descending Hypothalamic Projections to the Spinal Trigeminal Nucleus Caudalis in Rats. PLoS ONE, 2013, 8 (9), ⟨10.1371/annotation/7c794f90-1101-4196-8b10-4e3e320a7aac⟩. ⟨hal-01836263⟩
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ref_biblio: A. Normandin, P. Luccarini, L. Molat, L. Gendron, R. Dallel. Spinal and Opioids Inhibit Both Thermal and Mechanical Pain in Rats. Journal of Neuroscience, 2013, 33 (28), pp.11703 – 11714. ⟨10.1523/JNEUROSCI.1631-13.2013⟩. ⟨hal-01836258⟩
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2011

ref_biblio: Olivier Lapirot, Céline Melin, Alice Modolo, Charline Nicolas, Yassine Messaoudi, et al.. Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn. Pain, 2011, 152 (8), pp.1821 – 1831. ⟨10.1016/j.pain.2011.03.030⟩. ⟨hal-01836275⟩
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2009

ref_biblio: Olivier Lapirot, Raja Chebbi, Lénaic Monconduit, Alain Artola, Radhouane Dallel, et al.. NK1 receptor-expressing spinoparabrachial neurons trigger diffuse noxious inhibitory controls through lateral parabrachial activation in the male rat. Pain, 2009, 142 (3), pp.245-254. ⟨10.1016/j.pain.2009.01.015⟩. ⟨hal-04342345⟩
Accès au bibtex

2008

ref_biblio: Jerome Coste, Daniel L Voisin, Loïs S Miraucourt, Radhouane Dallel, Philippe L Luccarini. Dorsal horn NK1-expressing neurons control windup of downstream trigeminal nociceptive neurons. Pain, 2008, 137 (2), pp.340-351. ⟨10.1016/j.pain.2007.09.017⟩. ⟨hal-01543208⟩
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2006

ref_biblio: Jerome Coste, D L Voisin, P Luccarini, R Dallel. A Role For Wind-Up in Trigeminal Sensory Processing: Intensity Coding of Nociceptive Stimuli in the Rat. Cephalalgia, 2006, 28 (6), pp.631-639. ⟨10.1111/j.1468-2982.2008.01568.x⟩. ⟨hal-01543129⟩
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ref_biblio: Philippe Luccarini, Anne Childeric, Anne-Marie Gaydier, Daniel Voisin, Radhouane Dallel. The Orofacial Formalin Test in the Mouse: A Behavioral Model for Studying Physiology and Modulation of Trigeminal Nociception. The Journal of Pain, 2006, 7, pp.908 – 914. ⟨10.1016/j.jpain.2006.04.010⟩. ⟨hal-04468654⟩
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2004

ref_biblio: Philippe Luccarini, Laurent Perrier, Céline Dégoulange, Anne-Marie Gaydier, Radhouane Dallel. Synergistic Antinociceptive Effect of Amitriptyline and Morphine in the Rat Orofacial Formalin Test. Anesthesiology, 2004, 100 (3), pp.690 – 696. ⟨10.1097/00000542-200403000-00033⟩. ⟨hal-01836710⟩
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ref_biblio: Alain Woda, Olivier Blanc, Daniel L. Voisin, Jerome Coste, Jean-Louis Molat, et al.. Bidirectional modulation of windup by NMDA receptors in the rat spinal trigeminal nucleus. European Journal of Neuroscience, 2004, 19 (8), pp.2009-2016. ⟨10.1111/j.0953-816X.2004.03328.x⟩. ⟨hal-01543022⟩
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2003

ref_biblio: Philippe Luccarini, Melaine Henry, Pedro Alvarez, Anne-Marie Gaydier, Radhouane Dallel. Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain. Naunyn-Schmiedeberg’s Archives of Pharmacology, 2003, 368 (4), pp.320 – 323. ⟨10.1007/s00210-003-0799-z⟩. ⟨hal-01836288⟩
Accès au bibtex

2001

ref_biblio: Radhouane Dallel, Christian Duale, Philippe Luccarini, Jean‐louis Molat. Stimulus‐function, wind‐up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis. European Journal of Neuroscience, 2001, 11 (1), pp.31-40. ⟨10.1046/j.1460-9568.1999.00404.x⟩. ⟨hal-04342361⟩
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ref_biblio: P Luccarini, B.J Sessle, A Woda. SUPERFICIAL AND DEEP CONVERGENT NOCICEPTIVE NEURONS ARE DIFFERENTIALLY AFFECTED BY N-METHYL-D-ASPARTATE APPLIED ON THE BRAINSTEM SURFACE OF THE RAT MEDULLARY DORSAL HORN. Neuroscience, 2001, 107 (2), pp.311-316. ⟨10.1016/s0306-4522(01)00360-8⟩. ⟨hal-01836885⟩
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ref_biblio: A Woda, J.-L Molat, P Luccarini. LOW DOSES OF N-METHYL-D-ASPARTATE ANTAGONISTS IN SUPERFICIAL LAMINAE OF MEDULLA OBLONGATA FACILITATE WIND-UP OF CONVERGENT NEURONES. Neuroscience, 2001, 107 (2), pp.317-327. ⟨10.1016/s0306-4522(01)00359-1⟩. ⟨hal-01836873⟩
Accès au bibtex

1998

ref_biblio: Ph. Luccarini, R. Cadet, C. Duale, A. Woda. Effects of lesions in the trigeminal oralis and caudalis subnuclei on different orofacial nociceptive responses in the rat. Brain Research, 1998, 803 (1-2), pp.79 – 85. ⟨10.1016/s0006-8993(98)00624-6⟩. ⟨hal-01836898⟩
Accès au bibtex

1997

ref_biblio: C.A. Parada, P. Luccarini, A. Woda. Effect of an NMDA receptor antagonist on the wind-up of neurons in the trigeminal oralis subnucleus. Brain Research, 1997, 761 (2), pp.313-320. ⟨10.1016/s0006-8993(97)00355-7⟩. ⟨hal-04342380⟩
Accès au bibtex

1996

ref_biblio: Radhouane Dallel, Philippe Luccarini, Jean-Louis Molat, Alain Woda. Effects of systemic morphine on the activity of convergent neurons of spinal trigeminal nucleus oralis in the rat. European Journal of Pharmacology, 1996, 314 (1-2), pp.19-25. ⟨10.1016/s0014-2999(96)00480-3⟩. ⟨hal-04342383⟩
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ref_biblio: Christian Dualé, Philippe Luccarini, Rémi Cadet, Alain Woda. Effects of Morphine Microinjections into the Trigeminal Sensory Complex on the Formalin Test in the Rat. Experimental Neurology, 1996, 142 (2), pp.331-339. ⟨10.1006/exnr.1996.0202⟩. ⟨hal-01836912⟩
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1995

ref_biblio: P Luccarini, R Cadet, M. Saade, A Woda. Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.. NeuroReport, 1995, pp.365-8. ⟨hal-01836999⟩
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1993

ref_biblio: O Pompeiano, P Luccarini, Y Gahery, G. Blanchet. Somatotopical effects of local microinjection of GABAergic agents in Deiters nucleus on the posturokinetic responses to cortical stimulation.. Journal of Vestibular Research, 1993, pp.391-407. ⟨hal-01837025⟩
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1992

ref_biblio: P Luccarini, Y Gahery, G. Blanchet, O Pompeiano. GABA receptors in Deiters nucleus modulate posturokinetic responses to cortical stimulation in the cat.. Archives Italiennes de Biologie, 1992, pp.127-54. ⟨hal-01836995⟩
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1990

ref_biblio: P Luccarini, Y Gahery, O Pompeiano. Cholinoceptive pontine reticular structures modify the postural adjustments during the limb movements induced by cortical stimulation.. Archives Italiennes de Biologie, 1990, pp.19-45. ⟨hal-01837032⟩
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ref_biblio: P. Luccarini, Y. Gahery, O. Pompeiano. Injection of a cholinergic agonist in the dorsolateral pontine tegmentum of cats affects the posturokinetic responses to cortical stimulation. Neuroscience Letters, 1990, 114 (1), pp.75-81. ⟨10.1016/0304-3940(90)90431-8⟩. ⟨hal-04335739⟩
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Conference papers

2023

ref_biblio: Manon Dussol, Gisela da Silva Borges, Claudie Beaulieu, Philippe Luccarini, Louis Gendron. Implication of peripheral and central delta opioid receptors in migraine-like headache in rats.. International Headache Congress, International Headache Congress, Sep 2023, SEOUL, South Korea. ⟨hal-04213698⟩
Accès au bibtex

ref_biblio: Manon Dussol, Gisela da Silva Borges, Claudie Beaulieu, Philippe Luccarini, L Gendron, et al.. Rôle des récepteurs delta opioïdes dans la migraine. 23ème Congrès National de la SFETD, SFETD, Nov 2023, SAINT MALO, France. ⟨hal-04394940⟩
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ref_biblio: Jeanne Rossignol, Hervé Poras, T. Ouimet, Michel Wurm, Radhouane Dallel, et al.. Dual ENKephalinase Inhibitor (DENKI) PL37 as a potential novel treatment of migraine-like symptom. XVIIIeme Symposion du reseau Inserm de recherche sur la douleur, Mar 2023, Montpellier, France. ⟨hal-04605906⟩
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2019

ref_biblio: Amélie Descheemaeker, Hervé Poras, T. Ouimet, P. Luccarini, Michel Wurm, et al.. Dual ENKephalinase Inhibitor (DENKI) PL37: A possible new class of migraine therapeutics. XIXth International Headache Congress, Sep 2019, Dublin, Ireland. ⟨hal-04605885⟩
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ref_biblio: P. Luccarini, Marine Megemont, Amélie Descheemaeker, Radhouane Dallel, L. Monconduit. Astrocytes contribute to the trigeminal central sensitization and cephalic cutaneous hypersensitivity in rat model of chronic migraine.. NeuroFrance 2019 Congress, 23-24 mai 2019, Marseille (France)., Société des neurosciences, May 2019, MARSEILLE, France. ⟨hal-04605880⟩
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ref_biblio: Marine Megemont, Amélie Descheemaeker, Radhouane Dallel, L. Monconduit, P. Luccarini. Astrocytes contribute to the trigeminal central sensitization and cephalic cutaneous hypersensitivity in rat model of chronic migraine.. 15th Symposium de la Recherche du Réseau Douleur, Mar 2019, Paris, France. ⟨hal-04605879⟩
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2018

ref_biblio: Amélie Descheemaeker, Hervé Poras, P. Luccarini, Michel Wurm, Radhouane Dallel. Dual ENKephalinase Inhibitor (DENKI) PL37: A possible new class of migraine therapeutics.. 17th World Congress on Pain., Sep 2018, Boston (MA), United States. ⟨hal-04605849⟩
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ref_biblio: Marine Megemont, Amélie Descheemaeker, Radhouane Dallel, Lenaic Monconduit, P. Luccarini. Astrocytes contribute to the trigeminal central sensitization and cephalic cutaneous hypersensitivity in rat model of chronic migraine.. 12th European Headache Federation Congress, Sep 2018, Firenze (Florence), Italy. ⟨hal-04605851⟩
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2014

ref_biblio: Florian Jacquot, Radhouane Dallel, P. Luccarini, Alain Artola. Medial amygdala is involved in anxiety-like behavior induced by repeated dural nociception in rats. 9th FENS Forum of Neuroscience, Jul 2014, Milan, Italy. ⟨hal-04605886⟩
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2012

ref_biblio: Khaled Abdallah, Amandine Cavaroc, S. Tronche, Amandine Laurans, Radhouane Dallel, et al.. Neurochemical organization of descending hypothalamic projections to the medullay dorsal horn. 8ème FENS forum of Neuroscience, Jul 2012, Barcelonna, Spain. ⟨hal-04605890⟩
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ref_biblio: A. Normandin, P. Luccarini, J.-L Molat, Radhouane Dallel, Louis Gendron. Spinal mu opioid receptors regulate both heat and mechanical pain in rats.. The International Narcotics Research Conference 2012, Jul 2012, Kansas City (US), United States. ⟨hal-04605888⟩
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2010

ref_biblio: P. Luccarini, Olivier Lapirot, Alice Modolo, Claire Villemain, Charline Nicolas, et al.. Superficial medullary dorsal horn dopamine D2 receptors modulate mainly trigeminal C-fiber nociceptive transmission. 13th World Congress on Pain, IASP, Aug 2010, Montréal (Québec), Canada. ⟨hal-04605893⟩
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2008

ref_biblio: Raja Chebbi, Olivier Lapirot, Radhouane Dallel, P. Luccarini. Involvement of the nucleus raphe magnus in Diffuse Noxious Inhibitory Controls (DNIC) in the rat. 12th World Congress on pain, IASP, Aug 2008, Glasgow (Ecosse), United Kingdom. ⟨hal-04605901⟩
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2004

ref_biblio: Jerome Coste, Philippe Luccarini. Mécanismes d’amplification des messages nociceptifs dans le complexe sensitif du trijumeau chez le rat : approche électrophysiologique. Journées de l’Ecole Doctorale des Sciences de la Vie et de la Santé de l’Université d’Auvergne, Ecole Doctorale des Sciences de la Vie et de la Santé de l’Université d’Auvergne, Mar 2004, Clermont-Ferrand, France. ⟨hal-02071876⟩
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Book sections

2002

ref_biblio: P. Luccarini, A Woda. NMDA-dependent inhibition of wind-up in
Festschrift Kjell Hole 70 years. Pain and Brain. Festschrift Kjell Hole 70 years. Pain and Brain, NMDA-dependent inhibition of wind-up, Berge eds, pp.56, 2002. ⟨hal-04468841⟩
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2001

ref_biblio: P. Luccarini, R. Dallel. Nouvelles données dans l’approche électrophysiologique des mécanismes neuronaux de la nociception oro-faciale.. université de Saint Etienne. Actes du Colloque National de la Recherche en IUT 2001, tome 1, pp.165, 2001. ⟨hal-04468867⟩
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1992

ref_biblio: P. Luccarini, Y. Gahery, O. Pompeiano. Modulation of the early postural adjustments associated with a limb movement after microinjection of GABAergic agent in the Deiters nucleus. Woollacott M., Horak F. (Eds.). Posture and Gait: Control Mechanisms, 1, pp.14, 1992. ⟨hal-04468888⟩
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1990

ref_biblio: P. Luccarini, Y. Gahery, O. Pompeiano. Cholinergic mechanisms responsible for the gain regulation of the postural adjustments during the cortically induced limb movement. T. Brandt, W. Paulus, W. Bles, M. Dieterich, S. Krafczyk and A. Straube Editors. Disorders of Posture and Gait., Georg Thieme Verlag Stuttgart. New York, pp.346, 1990. ⟨hal-04468904⟩
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Habilitation à diriger des recherches

1999

ref_biblio: P Luccarini. TITRES et TRAVAUX. Sciences du Vivant [q-bio]. Université d’auvergne, 1999. ⟨tel-04355204⟩
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Poster communications

2006

ref_biblio: Olivier Roca-Lapirot, Jerome Coste, Radhouane Dallel, Philippe Luccarini. Diffuse noxious inhibitory controls depend on arterial blood pressure in the anaesthetized rat. Journée de la Recherche, Nov 2006, Clermont-Ferrand, France. 2006. ⟨hal-02071908⟩
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2005

ref_biblio: Jerome Coste, Radhouane Dallel, Philippe Luccarini. Lack of effect of diffuse noxious inhibitory controls triggered by cold on trigeminal convergent neurons in the anaesthetized rat. 7ème Colloque de la Société des Neurosciences, May 2005, Lille, France. ⟨hal-01871922⟩
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2003

ref_biblio: Jerome Coste, Daniel L Voisin, Philippe Luccarini, Maryse Chalus, Radhouane Dallel. Le wind-up des neurones nociceptifs trigéminaux dépend de l’activation des récepteurs NK1 situés dans le sous-noyau caudal. 6ème Colloque de la Société des Neurosciences, May 2003, Rouen, France. ⟨hal-01871916⟩
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Theses

1991

ref_biblio: Philippe Luccarini. Analyse des accompagnements posturaux associés à la flexion d’une patte chez le chat : modulation à partir du tegmentum pontique dorsolatéral et du noyau vestibulaire latéral. Neurobiologie. Université Aix Marseille 1, 1991. Français. ⟨NNT : ⟩. ⟨tel-04473601⟩
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