Nicolas KERCKHOVE

Journal articles

2025

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Célian Bertin, Nicolas Kerckhove, Florent Ferrer, Bruno Pereira, Christian Dualé, et al.. Buprenorphine Substitution as a Tapering Strategy for Opioid Discontinuation in Patients with Chronic Pain: A Nonrandomized and Proof of Concept Study. Pain and Therapy, 2025, ⟨10.1007/s40122-025-00781-z⟩. ⟨hal-05336978⟩

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Charlotte Lanhers, Christian Dualé, Alice Corteval, Emmanuel Coudeyre, Bruno Pereira, et al.. Male and female workers suffering from chronic low back pain display different interrelationships between the biopsychosocial variables. Journal of Rehabilitation Medicine, 2025, 57, pp.43450. ⟨10.2340/jrm.v57.43450⟩. ⟨hal-05336987⟩

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2024

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David Balayssac, Nicolas Kerckhove, Marie Selvy, Bruno Pereira, Coralie Gonneau, et al.. Motor disorders related to oxaliplatin-induced peripheral neuropathy: long-term severity and impact on quality of life. Supportive Care in Cancer, 2024, 32 (7), pp.427. ⟨10.1007/s00520-024-08627-8⟩. ⟨hal-04619673⟩

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Noémie Delage, Nathalie Cantagrel, Sandrine Soriot-Thomas, Marie Frost, Rodrigue Deleens, et al.. Mobile Health App and Web Platform (eDOL) for Medical Follow-Up of Patients With Chronic Pain: Cohort Study Involving the French eDOL National Cohort After 1 Year. JMIR mHealth and uHealth, 2024, 12, pp.e54579. ⟨10.2196/54579⟩. ⟨hal-04617487⟩

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2023

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Jessica Delorme, Nicolas Kerckhove, Nicolas Authier, Bruno Pereira, Célian Bertin, et al.. Systematic Review and Meta-Analysis of the Prevalence of Chronic Pain Among Patients With Opioid Use Disorder and Receiving Opioid Substitution Therapy. The Journal of Pain, 2023, 24 (2), pp.192-203. ⟨10.1016/j.jpain.2022.08.008⟩. ⟨hal-04865767⟩

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Elodie Picard, Nicolas Kerckhove, Amaury François, Ludivine Boudieu, Elisabeth Billard, et al.. Role of T CD4+ cells, macrophages, C-low threshold mechanoreceptors and spinal Cav3.2 channels in inflammation and related pain-like symptoms in murine inflammatory models. British Journal of Pharmacology, 2023, 180 (4), pp.385-400. ⟨10.1111/bph.15956⟩. ⟨hal-03790651⟩

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2022

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Celian Bertin, Julien Bezin, Chouki Chenaf, Jessica Delorme, Nicolas Kerckhove, et al.. Oral Morphine as an Alternative Substitution Treatment for Opioid Use Disorder, a Rare but Non-risk-free Use. Frontiers in Psychiatry, 2022, 13, ⟨10.3389/fpsyt.2022.893590⟩. ⟨hal-03815296⟩

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Noémie Delage, Nathalie Cantagrel, Jessica Delorme, Bruno Pereira, Christian Dualé, et al.. Transcultural validation of a French–European version of the Prescription Opioid Misuse Index Scale (POMI-5F). Canadian Journal of Anesthesia / Journal canadien d’anesthésie, 2022, 69 (8), pp.1042-1052. ⟨10.1007/s12630-022-02210-7⟩. ⟨hal-04741710⟩

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Fabrice Giraudet, Marie Selvy, Nicolas Kerckhove, Bruno Pereira, Fantine Barreau, et al.. Relation between auditory difficulties and bortezomib-induced peripheral neuropathy in multiple myeloma: a single-center cross-sectional study. European Archives of Oto-Rhino-Laryngology, 2022, 279 (4), pp.2197-2201. ⟨10.1007/s00405-021-07234-1⟩. ⟨hal-03813006⟩

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Nicolas Kerckhove, David Tougeron, Côme Lepage, Denis Pezet, Karine Le Malicot, et al.. Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial. BMC Cancer, 2022, 22 (1), pp.1-11. ⟨10.1186/s12885-022-09806-8⟩. ⟨hal-03770150⟩

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Nicolas Kerckhove, Noémie Delage, Sébastien Cambier, Nathalie Cantagrel, Eric Serra, et al.. eDOL mHealth App and Web Platform for Self-monitoring and Medical Follow-up of Patients With Chronic Pain: Observational Feasibility Study. JMIR Formative Research, 2022, 6 (3), pp.e30052. ⟨10.2196/30052⟩. ⟨hal-04744373⟩

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2021

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Nicolas Kerckhove, Marie Selvy, Céline Lambert, Coralie Gonneau, Gabrielle Feydel, et al.. Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy. Frontiers in Pharmacology, 2021, 12, pp.1-10. ⟨10.3389/fphar.2021.744085⟩. ⟨hal-03498040⟩

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Marie Selvy, Nicolas Kerckhove, Bruno Pereira, Fantine Barreau, Daniel Nguyen, et al.. Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study. Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.637593⟩. ⟨hal-03238418⟩

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Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Jérôme Busserolles, Fadila Farsi, et al.. Prevention, diagnosis and management of chemotherapy-induced peripheral neuropathy: a cross-sectional study of French oncologists’ professional practices. Supportive Care in Cancer, 2021, 29 (7), pp.4033-4043. ⟨10.1007/s00520-020-05928-6⟩. ⟨hal-03299953⟩

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2020

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Jérôme Busserolles, Stéphane Lolignier, Nicolas Kerckhove, Célian Bertin, Nicolas Authier, et al.. Replacement of current opioid drugs focusing on MOR-related strategies. Pharmacology and Therapeutics, 2020, 210, pp.107519. ⟨10.1016/j.pharmthera.2020.107519⟩. ⟨hal-03490336⟩

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Mélissa Cuménal, Marie Selvy, Nicolas Kerckhove, Célian Bertin, Margaux Morez, et al.. The Safety of Medications used to Treat Peripheral Neuropathic Pain, Part 2 (Opioids, Cannabinoids and Other Drugs): review of Double-Blind, Placebo-Controlled, Randomized Clinical Trials. Expert Opinion on Drug Safety, 2020, pp.1-18. ⟨10.1080/14740338.2021.1842871⟩. ⟨hal-02997543⟩

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Marie Selvy, Mélissa Cuménal, Nicolas Kerckhove, Christine Courteix, Jérôme Busserolles, et al.. The safety of medications used to treat peripheral neuropathic pain, part 1 (antidepressants and antiepileptics): review of double-blind, placebo-controlled, randomized clinical trials. Expert Opinion on Drug Safety, 2020, 19 (6), pp.707-733. ⟨10.1080/14740338.2020.1764934⟩. ⟨hal-02997564⟩

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Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Coralie Gonneau, Gabrielle Feydel, et al.. Long-Term Prevalence of Sensory Chemotherapy-Induced Peripheral Neuropathy for 5 Years after Adjuvant FOLFOX Chemotherapy to Treat Colorectal Cancer: A Multicenter Cross-Sectional Study. Journal of Clinical Medicine, 2020, 9 (8), pp.2400. ⟨10.3390/jcm9082400⟩. ⟨hal-02997588⟩

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2019

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Nicolas Kerckhove, Jérôme Busserolles, Trevor Stanbury, Bruno Pereira, Valérie Plence, et al.. Effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy: RILUZOX-01: protocol of a randomised, parallel, controlled, double-blind and multicentre study by the UNICANCER-AFSOS Supportive Care intergroup. BMJ Open, 2019, 9 (6), pp.e027770. ⟨10.1136/bmjopen-2018-027770⟩. ⟨hal-02325112⟩

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Nicolas Kerckhove, Ludivine Boudieu, Guillaume Ourties, Justine Bourdier, Laurence Daulhac, et al.. Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors. European Neuropsychopharmacology, 2019, 29, pp.1419 – 1432. ⟨10.1016/j.euroneuro.2019.10.012⟩. ⟨hal-03488870⟩

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Jérémy Pinguet, Nicolas Kerckhove, Teuta Eljezi, Celine Lambert, Emmanuel Moreau, et al.. New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices. Talanta, 2019, 198, pp.377-389. ⟨10.1016/j.talanta.2019.01.115⟩. ⟨hal-02194877⟩

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2018

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N. Kerckhove, B. Pereira, S. Picard, H. Alchaar, R. Deleens, et al.. Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial. European Journal of Pain, 2018, 22 (7), pp.1321 – 1330. ⟨10.1002/ejp.1221⟩. ⟨hal-01844578⟩

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Laura Poupon, Sylvain Lamoine, Vanessa Pereira, David Barriere, Stéphane Lolignier, et al.. Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. Neuropharmacology, 2018, 140, pp.43-61. ⟨10.1016/j.neuropharm.2018.07.026⟩. ⟨hal-02065469⟩

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2017

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Nicolas Kerckhove, Aurore Collin, Sakahlé Condé, Carine Chaleteix, Denis Pezet, et al.. Long-Term Effects, Pathophysiological Mechanisms, and Risk Factors of Chemotherapy-Induced Peripheral Neuropathies: A Comprehensive Literature Review. Frontiers in Pharmacology, 2017, 8, ⟨10.3389/fphar.2017.00086⟩. ⟨hal-01682157⟩

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Nicolas Kerckhove, Bruno Pereira, Denis Pezet, David Balayssac. Clinical assessment of new antineuropathic strategies for chemotherapy-induced peripheral neuropathy: pain should not be the principal endpoint. Pain, 2017, 158 (1), pp.180-182. ⟨10.1097/j.pain.0000000000000743⟩. ⟨hal-01607744⟩

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Nicolas Kerckhove, Julien Scanzi, Bruno Pereira, Denis Ardid, Michel Dapoigny. Assessment of the effectiveness and safety of ethosuximide in the treatment of abdominal pain related to irritable bowel syndrome – IBSET: protocol of a randomised, parallel, controlled, double-blind and multicentre trial. BMJ Open, 2017, 7 (7), pp.e015380. ⟨10.1136/bmjopen-2016-015380⟩. ⟨hal-04317249⟩

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2014

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Nicolas Kerckhove, Christophe Mallet, Amaury François, Mathieu Boudes, Jean Chemin, et al.. Cav3.2 calcium channels: the key protagonist of the supraspinal effect of paracetamol. Pain, 2014, 155 (4), pp.764-772. ⟨10.1016/j.pain.2014.01.015⟩. ⟨hal-02356344⟩

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2013

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Amaury François, Nicolas Kerckhove, Mathieu Meleine, Abdelkrim Alloui, Christian Barrère, et al.. State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects. Pain, 2013, 154 (2), pp.283-293. ⟨10.1016/j.pain.2012.10.023⟩. ⟨hal-02370536⟩

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Conference papers

2023

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Nicolas Kerckhove. Efficacité de l’éthosuximide sur les douleurs abdominales liées au SII. Réunion annuelle du Groupe Français de Neuro-Gastroentérologe (GFNG), Jun 2023, CLERMONT FERRAND, France. ⟨hal-04869419⟩

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2021

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Ophélie Uriot, Elora Fournier, Frédérique Lajoie, Nicolas Kerckhove, Julien Scanzi, et al.. Development of an in vitro model of dysbiotic colonic conditions of IBS-D patients. 12. International Symposium on Gut Microbiology, INRAE ; Rowett Institute UK, Oct 2021, En ligne, France. ⟨hal-03402422⟩

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Poster communications

2024

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Célian Bertin, Nicolas Kerckhove, Christine Fournier-Choma, Nicolas Authier, Noémie Delage. La Buprénorphine comme stratégie de sevrage des antalgiques opioïdes, après échec d’un sevrage progressif chez les patients souffrant de douleur chronique non cancéreuse. Addictions, Toxicomanies, Hépatites et Sida (ATHS), Nov 2024, Biarritz, France. ⟨hal-04869525⟩

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Célian Bertin, Nicolas Kerckhove, Nicolas Authier, Noémie Delage. La Buprénorphine comme stratégie de sevrage des antalgiques opioïdes après échec d’un sevrage progressif chez les patients souffrant de douleur chronique non cancéreuse (étude SEVROP). SFETD, Nov 2024, LILLE, France. ⟨hal-04869609⟩

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Nadège Bornier, Aurélien Mulliez, Chouki Chenaf, Antoine Elyn, Sarah Teixeira, et al.. Chronic pain is a risk factor for incident Alzheimer’s disease a nationwide propensity matched cohort using administrative data. SFETD, Nov 2024, LILLE, France. ⟨hal-04869452⟩

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Nicolas Kerckhove, Nadège Bornier, Aurélien Mulliez, Antoine Elyn, Sarah Teixeira, et al.. Prevalence of Chronic Pain Among People with Dementia A Nationwide Study Using French Administrative Data. SFETD, Nov 2024, LILLE, France. ⟨hal-04869625⟩

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Nicolas Kerckhove, Chloé Melchior, Frank Zerbib, Marion Chambaz, François Mion, et al.. Ethosuximide to treat abdominal pain related to Irritable Bowel Syndrome a randomized, controlled, double blind and multicenter study. SFETD, Nov 2024, LILLE, France. ⟨hal-04869650⟩

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2023

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Armel Soubeiga, Jessem Ettaghouti, Violaine Antoine, Alice Corteval, Nicolas Kerckhove, et al.. Clustering de séries chronologiques de patients souffrant de douleurs chroniques. Extraction et Gestion des Connaissances (EGC) – 2023, Jan 2023, Lyon, France. . ⟨hal-04063254⟩

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Ophélie Uriot, Sylvain Denis, Nicolas Kerckhove, Julien Scanzi, Lucie Etienne-Mesmin, et al.. Development of a new in vitro model of inflammatory bowel syndrome gut microbiome. 10th FEMS Congress of European Microbiologists, Jul 2023, Hambourg (Neversdorf), Germany. ⟨hal-04215089⟩

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2021

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Ophélie Uriot, Elora Fournier, Frédérique Lajoie, N. Kerckhove, Julien Scanzi, et al.. Development of an in vitro model of dysbiotic colonic conditions of IBS-D patients. 12. International symposium on Gut Microbiology, Oct 2021, Clermont-Ferrand (online), France. ⟨hal-03739752⟩

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Theses

2013

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Nicolas Kerckhove. Implication des canaux Cav3.2 dans l’effet antalgique du paracétamol et dans la douleur inflammatoire. Pharmacologie. Université d’Auvergne – Clermont-Ferrand I, 2013. Français. ⟨NNT : 2013CLF1PP04⟩. ⟨tel-01165233⟩

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