Nicolas KERCKHOVE

UMR 1107 INSERM/UCA Neuro-Dol
Facultés de Médecine et Pharmacie
Place Henri Dunant
63001 Clermont-Ferrand
FRANCE

Nicolas KERCKHOVE

Chef de Projet Clinique
Equipe Pharmacologie Fondamentale et Clinique de la Douleur, Équipe PFCD – Axe Patient

nicolas.kerckhove@-Code to remove to avoid SPAM-uca.fr

Publications HAL

Article dans une revue

2024

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David Balayssac, Nicolas Kerckhove, Marie Selvy, Bruno Pereira, Coralie Gonneau, et al.. Motor disorders related to oxaliplatin-induced peripheral neuropathy: long-term severity and impact on quality of life. Supportive Care in Cancer, 2024, 32 (7), pp.427. ⟨10.1007/s00520-024-08627-8⟩. ⟨hal-04619673⟩
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https://hal.science/hal-04619673/file/PREVOX%20motor%20-%20Supp%20Care%20Cancer%20-%20Manuscript%20HAL.pdf


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Noémie Delage, Nathalie Cantagrel, Sandrine Soriot-Thomas, Marie Frost, Rodrigue Deleens, et al.. Mobile Health App and Web Platform (eDOL) for Medical Follow-Up of Patients With Chronic Pain: Cohort Study Involving the French eDOL National Cohort After 1 Year. JMIR mHealth and uHealth, 2024, 12, pp.e54579. ⟨10.2196/54579⟩. ⟨hal-04816684⟩
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Noémie Delage, Nathalie Cantagrel, Sandrine Soriot-Thomas, Marie Frost, Rodrigue Deleens, et al.. Mobile Health App and Web Platform (eDOL) for Medical Follow-Up of Patients With Chronic Pain: Cohort Study Involving the French eDOL National Cohort After 1 Year. JMIR mHealth and uHealth, 2024, 12, pp.e54579. ⟨10.2196/54579⟩. ⟨hal-04617487⟩
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https://hal.science/hal-04617487/file/mhealth-2024-1-e54579.pdf


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2023

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Elodie Picard, Nicolas Kerckhove, Amaury François, Ludivine Boudieu, Elisabeth Billard, et al.. Role of T CD4+ cells, macrophages, C-low threshold mechanoreceptors and spinal Cav3.2 channels in inflammation and related pain-like symptoms in murine inflammatory models. British Journal of Pharmacology, 2023, 180 (4), pp.385-400. ⟨10.1111/bph.15956⟩. ⟨hal-03790651⟩
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2022

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Celian Bertin, Julien Bezin, Chouki Chenaf, Jessica Delorme, Nicolas Kerckhove, et al.. Oral Morphine as an Alternative Substitution Treatment for Opioid Use Disorder, a Rare but Non-risk-free Use. Frontiers in Psychiatry, 2022, 13, ⟨10.3389/fpsyt.2022.893590⟩. ⟨hal-03815296⟩
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https://hal.science/hal-03815296/file/BPH_FP_2022_Bertin.pdf


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Noémie Delage, Nathalie Cantagrel, Jessica Delorme, Bruno Pereira, Christian Dualé, et al.. Transcultural validation of a French–European version of the Prescription Opioid Misuse Index Scale (POMI-5F). Canadian Journal of Anesthesia / Journal canadien d’anesthésie, 2022, 69 (8), pp.1042-1052. ⟨10.1007/s12630-022-02210-7⟩. ⟨hal-04256540⟩
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Noémie Delage, Nathalie Cantagrel, Jessica Delorme, Bruno Pereira, Christian Dualé, et al.. Transcultural validation of a French–European version of the Prescription Opioid Misuse Index Scale (POMI-5F). Canadian Journal of Anesthesia / Journal canadien d’anesthésie, 2022, 69 (8), pp.1042-1052. ⟨10.1007/s12630-022-02210-7⟩. ⟨hal-04741710⟩
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Fabrice Giraudet, Marie Selvy, Nicolas Kerckhove, Bruno Pereira, Fantine Barreau, et al.. Relation between auditory difficulties and bortezomib-induced peripheral neuropathy in multiple myeloma: a single-center cross-sectional study. European Archives of Oto-Rhino-Laryngology, 2022, 279 (4), pp.2197-2201. ⟨10.1007/s00405-021-07234-1⟩. ⟨hal-03813006⟩
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Nicolas Kerckhove, Noémie Delage, Sébastien Cambier, Nathalie Cantagrel, Eric Serra, et al.. eDOL mHealth App and Web Platform for Self-monitoring and Medical Follow-up of Patients With Chronic Pain: Observational Feasibility Study. JMIR Formative Research, 2022, 6 (3), pp.e30052. ⟨10.2196/30052⟩. ⟨hal-04256443⟩
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Nicolas Kerckhove, Noémie Delage, Sébastien Cambier, Nathalie Cantagrel, Eric Serra, et al.. eDOL mHealth App and Web Platform for Self-monitoring and Medical Follow-up of Patients With Chronic Pain: Observational Feasibility Study. JMIR Formative Research, 2022, 6 (3), pp.e30052. ⟨10.2196/30052⟩. ⟨hal-04744373⟩
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Nicolas Kerckhove, David Tougeron, Côme Lepage, Denis Pezet, Karine Le Malicot, et al.. Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial. BMC Cancer, 2022, 22 (1), pp.1-11. ⟨10.1186/s12885-022-09806-8⟩. ⟨hal-03770150⟩
Accès au texte intégral et bibtex

https://hal.inrae.fr/hal-03770150/file/2022_Kerckhove_BMC_Cancer.pdf


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2021

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Nicolas Kerckhove, Marie Selvy, Céline Lambert, Coralie Gonneau, Gabrielle Feydel, et al.. Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy. Frontiers in Pharmacology, 2021, 12, pp.1-10. ⟨10.3389/fphar.2021.744085⟩. ⟨hal-03498040⟩
Accès au texte intégral et bibtex

https://hal.inrae.fr/hal-03498040/file/2021_Kerckhove_Frontiers_in_Pharmacology.pdf


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Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Jérôme Busserolles, Fadila Farsi, et al.. Prevention, diagnosis and management of chemotherapy-induced peripheral neuropathy: a cross-sectional study of French oncologists’ professional practices. Supportive Care in Cancer, 2021, 29 (7), pp.4033-4043. ⟨10.1007/s00520-020-05928-6⟩. ⟨hal-03299953⟩
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Marie Selvy, Nicolas Kerckhove, Bruno Pereira, Fantine Barreau, Daniel Nguyen, et al.. Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study. Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.637593⟩. ⟨hal-03238418⟩
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https://hal.inrae.fr/hal-03238418/file/2021_Selvy_Front_Pharmacol.pdf


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2020

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Jérôme Busserolles, Stéphane Lolignier, Nicolas Kerckhove, Célian Bertin, Nicolas Authier, et al.. Replacement of current opioid drugs focusing on MOR-related strategies. Pharmacology and Therapeutics, 2020, 210, pp.107519. ⟨10.1016/j.pharmthera.2020.107519⟩. ⟨hal-03490336⟩
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https://hal.science/hal-03490336/file/S0163725820300474.pdf


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Mélissa Cuménal, Marie Selvy, Nicolas Kerckhove, Célian Bertin, Margaux Morez, et al.. The Safety of Medications used to Treat Peripheral Neuropathic Pain, Part 2 (Opioids, Cannabinoids and Other Drugs): review of Double-Blind, Placebo-Controlled, Randomized Clinical Trials. Expert Opinion on Drug Safety, 2020, pp.1-18. ⟨10.1080/14740338.2021.1842871⟩. ⟨hal-02997543⟩
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https://uca.hal.science/hal-02997543/file/Medications_safety_2_-_EODS.pdf


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Marie Selvy, Mélissa Cuménal, Nicolas Kerckhove, Christine Courteix, Jérôme Busserolles, et al.. The safety of medications used to treat peripheral neuropathic pain, part 1 (antidepressants and antiepileptics): review of double-blind, placebo-controlled, randomized clinical trials. Expert Opinion on Drug Safety, 2020, 19 (6), pp.707-733. ⟨10.1080/14740338.2020.1764934⟩. ⟨hal-02997564⟩
Accès au texte intégral et bibtex

https://uca.hal.science/hal-02997564/file/Medications_safety_-_EODS.pdf


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Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Coralie Gonneau, Gabrielle Feydel, et al.. Long-Term Prevalence of Sensory Chemotherapy-Induced Peripheral Neuropathy for 5 Years after Adjuvant FOLFOX Chemotherapy to Treat Colorectal Cancer: A Multicenter Cross-Sectional Study. Journal of Clinical Medicine, 2020, 9 (8), pp.2400. ⟨10.3390/jcm9082400⟩. ⟨hal-02997588⟩
Accès au texte intégral et bibtex

https://uca.hal.science/hal-02997588/file/jcm-09-02400-v2.pdf


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2019

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Nicolas Kerckhove, Jérôme Busserolles, Trevor Stanbury, Bruno Pereira, Valérie Plence, et al.. Effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy: RILUZOX-01: protocol of a randomised, parallel, controlled, double-blind and multicentre study by the UNICANCER-AFSOS Supportive Care intergroup. BMJ Open, 2019, 9 (6), pp.e027770. ⟨10.1136/bmjopen-2018-027770⟩. ⟨hal-02325112⟩
Accès au texte intégral et bibtex

https://hal.science/hal-02325112/file/bmjopen-2018-027770.pdf


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Nicolas Kerckhove, Ludivine Boudieu, Guillaume Ourties, Justine Bourdier, Laurence Daulhac, et al.. Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors. European Neuropsychopharmacology, 2019, 29, pp.1419 – 1432. ⟨10.1016/j.euroneuro.2019.10.012⟩. ⟨hal-03488870⟩
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https://hal.science/hal-03488870/file/S0924977X19317249.pdf


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Jérémy Pinguet, Nicolas Kerckhove, Teuta Eljezi, Celine Lambert, Emmanuel Moreau, et al.. New SPE-LC-MS/MS method for the simultaneous determination in urine of 22 metabolites of DEHP and alternative plasticizers from PVC medical devices. Talanta, 2019, 198, pp.377-389. ⟨10.1016/j.talanta.2019.01.115⟩. ⟨hal-02194877⟩
Accès au texte intégral et bibtex

https://hal.science/hal-02194877/file/S0039914019300670.pdf


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2018

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N. Kerckhove, B. Pereira, S. Picard, H. Alchaar, R. Deleens, et al.. Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial. European Journal of Pain, 2018, 22 (7), pp.1321 – 1330. ⟨10.1002/ejp.1221⟩. ⟨hal-01844578⟩
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Laura Poupon, Sylvain Lamoine, Vanessa Pereira, David Barriere, Stéphane Lolignier, et al.. Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. Neuropharmacology, 2018, 140, pp.43-61. ⟨10.1016/j.neuropharm.2018.07.026⟩. ⟨hal-02065469⟩
Accès au texte intégral et bibtex

https://hal.science/hal-02065469/file/Poupon_Targeting_TREK-1_CombinedAAM.pdf


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2017

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Nicolas Kerckhove, Julien Scanzi, Bruno Pereira, Denis Ardid, Michel Dapoigny. Assessment of the effectiveness and safety of ethosuximide in the treatment of abdominal pain related to irritable bowel syndrome – IBSET: protocol of a randomised, parallel, controlled, double-blind and multicentre trial. BMJ Open, 2017, 7 (7), pp.e015380. ⟨10.1136/bmjopen-2016-015380⟩. ⟨hal-04317249⟩
Accès au texte intégral et bibtex

https://hal.science/hal-04317249/file/main.pdf


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Nicolas Kerckhove, Aurore Collin, Sakahlé Condé, Carine Chaleteix, Denis Pezet, et al.. Long-Term Effects, Pathophysiological Mechanisms, and Risk Factors of Chemotherapy-Induced Peripheral Neuropathies: A Comprehensive Literature Review. Frontiers in Pharmacology, 2017, 8, ⟨10.3389/fphar.2017.00086⟩. ⟨hal-01682157⟩
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Nicolas Kerckhove, Bruno Pereira, Denis Pezet, David Balayssac. Clinical assessment of new antineuropathic strategies for chemotherapy-induced peripheral neuropathy: pain should not be the principal endpoint. Pain, 2017, 158 (1), pp.180-182. ⟨10.1097/j.pain.0000000000000743⟩. ⟨hal-01607744⟩
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2014

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Nicolas Kerckhove, Christophe Mallet, Amaury François, Mathieu Boudes, Jean Chemin, et al.. Cav3.2 calcium channels: the key protagonist of the supraspinal effect of paracetamol. Pain, 2014, 155 (4), pp.764-772. ⟨10.1016/j.pain.2014.01.015⟩. ⟨hal-02356344⟩
Accès au texte intégral et bibtex

https://hal.science/hal-02356344/file/Kerckhove%20et%20al%20%282014%29%20Pain%20-%20Paracetamol%20and%20Cav3.2.pdf


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2013

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Amaury François, Nicolas Kerckhove, Mathieu Meleine, Abdelkrim Alloui, Christian Barrère, et al.. State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects. Pain, 2013, 154 (2), pp.283-293. ⟨10.1016/j.pain.2012.10.023⟩. ⟨hal-02370536⟩
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Communication dans un congrès

2021

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Ophélie Uriot, Elora Fournier, Frédérique Lajoie, Nicolas Kerckhove, Julien Scanzi, et al.. Development of an in vitro model of dysbiotic colonic conditions of IBS-D patients. 12. International Symposium on Gut Microbiology, INRAE ; Rowett Institute UK, Oct 2021, En ligne, France. ⟨hal-03402422⟩
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Poster de conférence

2023

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Armel Soubeiga, Jessem Ettaghouti, Violaine Antoine, Alice Corteval, Nicolas Kerckhove, et al.. Clustering de séries chronologiques de patients souffrant de douleurs chroniques. Extraction et Gestion des Connaissances (EGC) – 2023, Jan 2023, Lyon, France. . ⟨hal-04063254⟩
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https://hal.science/hal-04063254/file/Poster_eDOL.pdf


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Ophélie Uriot, Sylvain Denis, Nicolas Kerckhove, Julien Scanzi, Lucie Etienne-Mesmin, et al.. Development of a new in vitro model of inflammatory bowel syndrome gut microbiome. 10th FEMS Congress of European Microbiologists, Jul 2023, Hambourg (Neversdorf), Germany. ⟨hal-04215089⟩
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2021

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Ophélie Uriot, Elora Fournier, Frédérique Lajoie, N. Kerckhove, Julien Scanzi, et al.. Development of an in vitro model of dysbiotic colonic conditions of IBS-D patients. 12. International symposium on Gut Microbiology, Oct 2021, Clermont-Ferrand (online), France. ⟨hal-03739752⟩
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Thèse

2013

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Nicolas Kerckhove. Implication des canaux Cav3.2 dans l’effet antalgique du paracétamol et dans la douleur inflammatoire. Pharmacologie. Université d’Auvergne – Clermont-Ferrand I, 2013. Français. ⟨NNT : 2013CLF1PP04⟩. ⟨tel-01165233⟩
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https://theses.hal.science/tel-01165233/file/Kerckhove-2013CLF1PP04.pdf


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