Mickael ZBILI (EN)
NEURO-DOL – UMR1107 INSERM/UCA 2, rue de Braga, 63100, Clermont-Ferrand (FRANCE)
Dr. Mickael ZBILI
Assistant Professor
Team TPM – Pathophysiology of mechanical allodynia axis, Team Trigeminal Pain and Migraine
Team TPM – Pathophysiology of mechanical allodynia axis, Team Trigeminal Pain and Migraine
mickael.zbili@-Code to remove to avoid SPAM-uca.fr
+33 4 73 17 73 17, room 245
+33 4 73 17 73 17, room 245
Student :
Research Theme:
Axis Pathophysiology of mechanical allodynia
My research theme concerns alterations of neuronal coding in the cortex in neuropathic pain conditions. I am trying to understand how the deregulation of axonal ion channels in neuropathic conditions alters the coding and propagation of the nerve signal inducing the painful sensation.
My research theme concerns alterations of neuronal coding in the cortex in neuropathic pain conditions. I am trying to understand how the deregulation of axonal ion channels in neuropathic conditions alters the coding and propagation of the nerve signal inducing the painful sensation.
Techniques Used:
patch-clamp (soma, axon, dendrite), computational modeling, immunohistochemistry, calcium imaging, voltage imaging, behavior
Functions:
Teacher-Researcher at Clermont-Auvergne University
Education:
- 2007-2012: Bachelor’s degree in Biology and Master’s degree in Integrative Biology and Physiology option Neuroscience (Ecole Normale Supérieure / Pierre and Marie Curie University – Paris VI).
- 2012-2017: Doctorate in Neuroscience (UNIS, Inserm U1072, Marseille).
- 2017-2020: PostDoctorate and ATER (CRNL, INSERM U1028 – CNRS UMR 5292, Lyon).
- 2020-2022: PostDoctorate (Blue Brain Project, Geneva).
- 2022 – Present: Teacher-Researcher (NeuroDol, Inserm U1107, Clermont-Ferrand).
Teachings:
Human physiology, Cellular neuroscience, Biostatistics, Critical reading of scientific articles.
Image:
HAL Publications
Journal articles
2025
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- Maria Reva, Alexis Arnaudon, Mickael Zbili, Abdullah Makkeh, Henry Markram, et al.. Higher-order interactions in neuronal function: From genes to ionic currents in biophysical models. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (40), ⟨10.1073/pnas.2500048122⟩. ⟨hal-05289784⟩
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2024
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- Alessio Paolo Buccino, Tanguy Damart, Julian Bartram, Darshan Mandge, Xiaohan Xue, et al.. A Multimodal Fitting Approach to Construct Single-Neuron Models With Patch Clamp and High-Density Microelectrode Arrays. Neural Computation, 2024, 36 (7), pp.1286-1331. ⟨10.1162/neco_a_01672⟩. ⟨hal-04610077⟩
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2023
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- Alexis Arnaudon, Maria Reva, Mickael Zbili, Henry Markram, Werner van Geit, et al.. Controlling morpho-electrophysiological variability of neurons with detailed biophysical models. iScience, 2023, 26 (11), pp.108222. ⟨10.1016/j.isci.2023.108222⟩. ⟨hal-04272072⟩
- Accès au texte intégral et bibtex
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- ref_biblio
- Maxime Juventin, Mickael Zbili, Nicolas Fourcaud-Trocmé, Samuel Garcia, Nathalie Buonviso, et al.. Respiratory rhythm modulates membrane potential and spiking of non-olfactory neurons. Journal of Neurophysiology, 2023, 130 (6), pp.1552-1566. ⟨10.1152/jn.00487.2022⟩. ⟨hal-04335818⟩
- Accès au texte intégral et bibtex
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2022
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- Nicolas Fourcaud-Trocmé, Mickaël Zbili, Patricia Duchamp-Viret, Nicola Kuczewski. Afterhyperpolarization Promotes the Firing of Mitral Cells through a Voltage-Dependent Modification of Action Potential Threshold. eNeuro, 2022, 9 (2), pp.ENEURO.0401 – 21.2021. ⟨10.1523/ENEURO.0401-21.2021⟩. ⟨hal-03765007⟩
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2021
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- Mickaël Zbili, Sylvain Rama, Maria-José Benitez, Laure Fronzaroli-Molinieres, Andrzej Bialowas, et al.. Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. Proceedings of the National Academy of Sciences of the United States of America, 2021, ⟨10.1073/pnas.2110601118⟩. ⟨hal-03439967⟩
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- ref_biblio
- Mickael Zbili, Sylvain Rama. A Quick and Easy Way to Estimate Entropy and Mutual Information for Neuroscience. Frontiers in Neuroinformatics, 2021, 15, pp.596443. ⟨10.3389/fninf.2021.596443⟩. ⟨hal-04272011⟩
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- ref_biblio
- Mickaël Zbili, Sylvain Rama, Maria-José Benitez, Laure Fronzaroli-Molinieres, Andrzej Bialowas, et al.. Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), pp.e2110601118. ⟨10.1073/pnas.2110601118⟩. ⟨hal-04272027⟩
- Accès au texte intégral et bibtex
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2020
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- Mickaël Zbili, Sylvain Rama, Pierre Yger, Yanis Inglebert, Norah Boumedine-Guignon, et al.. Axonal Na + channels detect and transmit levels of input synchrony in local brain circuits. Science Advances , 2020, 6 (19), pp.eaay4313. ⟨10.1126/sciadv.aay4313⟩. ⟨hal-03044417⟩
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- ref_biblio
- Mickaël Zbili, Dominique Debanne. Corrigendum: Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study. Frontiers in Cellular Neuroscience, 2020, 14, ⟨10.3389/fncel.2020.00099⟩. ⟨hal-03139013⟩
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- ref_biblio
- Mickaël Zbili, Dominique Debanne. Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study. Frontiers in Cellular Neuroscience, 2020, 14, ⟨10.3389/fncel.2020.00040⟩. ⟨hal-04272001⟩
- Accès au texte intégral et bibtex
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- ref_biblio
- Mickaël Zbili, Sylvain Rama, Pierre Yger, Yanis Inglebert, Norah Boumedine-Guignon, et al.. Axonal Na + channels detect and transmit levels of input synchrony in local brain circuits. Science Advances , 2020, 6 (19), ⟨10.1126/sciadv.aay4313⟩. ⟨hal-04272009⟩
- Accès au bibtex
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- ref_biblio
- Mickaël Zbili, Dominique Debanne. Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study. Frontiers in Cellular Neuroscience, 2020, 14, ⟨10.3389/fncel.2020.00040⟩. ⟨hal-03044394⟩
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2019
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- Mickael Zbili, Dominique Debanne. Past and future of analog-digital modulation of synaptic transmission. Frontiers in Cellular Neuroscience, 2019, 13, ⟨10.3389/fncel.2019.00160⟩. ⟨hal-02363629⟩
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- ref_biblio
- Mickael Zbili, Dominique Debanne. Past and Future of Analog-Digital Modulation of Synaptic Transmission. Frontiers in Cellular Neuroscience, 2019, 13, ⟨10.3389/fncel.2019.00160⟩. ⟨hal-04271999⟩
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2018
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- Sylvain Rama, Mickael Zbili, Dominique Debanne. Signal propagation along the axon. Current Opinion in Neurobiology, 2018, 51, pp.37-44. ⟨10.1016/j.conb.2018.02.017⟩. ⟨hal-01963472⟩
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- ref_biblio
- Sylvain Rama, Mickaël Zbili, Dominique Debanne. Signal propagation along the axon. Current Opinion in Neurobiology, 2018, 51, pp.37-44. ⟨10.1016/j.conb.2018.02.017⟩. ⟨hal-04271990⟩
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2017
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- Sylvain Rama, Mickael Zbili, Aurélie Fékété, Mónica Tapia, Maria José Benitez, et al.. The role of axonal Kv1 channels in CA3 pyramidal cell excitability. Scientific Reports, 2017, 7 (1), pp.315. ⟨10.1038/s41598-017-00388-1⟩. ⟨hal-04271982⟩
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- ref_biblio
- Sylvain Rama, Mickael Zbili, Aurélie Fékété, Mónica Tapia, Maria Jose Benitez, et al.. The role of axonal Kv1 channels in CA3 pyramidal cell excitability. Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-00388-1⟩. ⟨hal-01766826⟩
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- ref_biblio
- Michael Seagar, Michaël Russier, Olivier Caillard, Yves Maulet, Laure Fronzaroli-Molinieres, et al.. LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (29), pp.7719 – 7724. ⟨10.1073/pnas.1618656114⟩. ⟨inserm-01708767⟩
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2016
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- Mickael Zbili, Sylvain Rama, Dominique Debanne. Dynamic Control of Neurotransmitter Release by Presynaptic Potential. Frontiers in Cellular Neuroscience, 2016, 10, ⟨10.3389/fncel.2016.00278⟩. ⟨hal-04271974⟩
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- ref_biblio
- Mickael Zbili, Sylvain Rama, Dominique Debanne. Dynamic Control of Neurotransmitter Release by Presynaptic Potential. Frontiers in Cellular Neuroscience, 2016, 10, pp.278. ⟨10.3389/fncel.2016.00278⟩. ⟨hal-01766828⟩
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2015
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- Andrzej Bialowas, Sylvain Rama, Mickael Zbili, Vincenzo Marra, Laure Fronzaroli-Molinieres, et al.. Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent manner. European Journal of Neuroscience, 2015, 41 (3), pp.293-304. ⟨10.1111/ejn.12787⟩. ⟨hal-01766833⟩
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- Andrzej Bialowas, Sylvain Rama, Mickaël Zbili, Vincenzo Marra, Laure Fronzaroli-Molinieres, et al.. Analog modulation of spike‐evoked transmission in CA 3 circuits is determined by axonal K v1.1 channels in a time‐dependent manner. European Journal of Neuroscience, 2015, 41 (3), pp.293-304. ⟨10.1111/ejn.12787⟩. ⟨hal-04271944⟩
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- ref_biblio
- Sylvain Rama, Mickael Zbili, Andrzej Bialowas, Laure Fronzaroli-Molinieres, Norbert Ankri, et al.. Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels. Nature Communications, 2015, 6 (1), pp.10163. ⟨10.1038/ncomms10163⟩. ⟨hal-01766831⟩
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- ref_biblio
- Sylvain Rama, Mickaël Zbili, Andrzej Bialowas, Laure Fronzaroli-Molinieres, Norbert Ankri, et al.. Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels. Nature Communications, 2015, 6 (1), pp.10163. ⟨10.1038/ncomms10163⟩. ⟨hal-04271970⟩
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- ref_biblio
- Sylvain Rama, Mickaël Zbili, Dominique Debanne. Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels. Biochimica et Biophysica Acta – Molecular Cell Research, 2015, 1853 (9), pp.1933-1939. ⟨10.1016/j.bbamcr.2014.11.024⟩. ⟨hal-04271951⟩
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Poster communications
2023
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- Corine Amat, Zbili Mickael, Maxime Juventin, Nicola Kuczewski, Nicolas Fourcaud-Trocmé. Correlation between sag and AHP is a determinant of olfactory bulb mitral cell spiking. NeuroFrance 2023, May 2023, Lyon, France. ⟨hal-04610089⟩
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2022
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- Corine Amat, Maxime Juventin, Mickael Zbili, Samuel Garcia, Nathalie Buonviso, et al.. Respiratory modulation in the brain: deep in the cells. FENS 2022, 2022, Paris, France. ⟨hal-03758949⟩
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- Zbili Mickael, Stijn van Dorp, Emmanuelle Logette, Rajnish Ranjan, Rodrigo Perrin, et al.. Channel noise leads to larger stochastic voltage fluctuations in the axon than in the soma. Fens Forum 2022, Jul 2022, Paris, France. ⟨hal-04610168⟩
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2021
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- Zbili Mickael, Werner van Geit, Henry Markram. Channel noise leads to larger stochastic voltage fluctuations in the axon than in the soma. Embo Workshop Axons 2021, Oct 2021, On line, France. ⟨hal-04610193⟩
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2020
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- Corine Amat, Zbili Mickael, Maxime Juventin, Nicola Kuczewski, Nicolas Fourcaud-Trocmé. Mitral cell spiking is determined by the covariation between Ih and spike afterhyperpolarization. Fens Forum 2020, Jul 2020, On line and Virtual, France. ⟨hal-04610195⟩
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- Maxime Juventin, Baptiste Girin, Mickaël Zbili, Nicolas Fourcaud-Trocmé, Samuel Garcia, et al.. Neurons membrane potential beats to the rhythm of breath. FENS ( Federation of European Neuroscience Societies ) 2020, 2020, Virtual forum, France. ⟨hal-03758974⟩
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2019
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- Dominique Debanne, Zbili Mickael, Sylvain Rama, Yanis Inglebert, Norah Boumedine-Guignon, et al.. Axonal sodium channels read and transmit input synchrony in local brain circuits. Neurofrance 2019, May 2019, Marseille, France. ⟨hal-04610202⟩
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- ref_biblio
- Zbili Mickael, Nicolas Fourcaud-Trocmé, Corine Amat. Is Ih responsible for mitral cells respiratory-driven slow oscillations?. NeuroFrance 2019, May 2019, Marseille, France. ⟨hal-04610197⟩
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Preprints, Working Papers, …
2025
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- Justine Loudan, Karine Herault, Tanguy Damart, Pauline Murail, Alexanne Michon, et al.. Sex-specific axon initial segment plasticity underlies cortical hyperexcitability in trigeminal pain. 2025. ⟨hal-05338933⟩
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- Ahmed Negm, François Gabrielli, Mickael Zbili, Louis Poncet-Megemont, Karine Herault, et al.. Sensory plasticity of dorsal horn silent neurons: a critical mechanism for neuropathic pain. 2025. ⟨hal-05336997⟩
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2022
- ref_biblio
- Maxime Juventin, Mickael Zbili, Nicolas Fourcaud-Trocmé, Samuel Garcia, N. Buonviso, et al.. Respiratory rhythm entrains membrane potential and spiking of non-olfactory neurons. 2022. ⟨hal-03765341⟩
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2021
- ref_biblio
- Nicolas Fourcaud-Trocmé, Mickaël Zbili, Patricia Duchamp-Viret, Nicola Kuczewski. After-hyperpolarization promotes the firing of mitral cells through a voltage dependent modification of action potential threshold. 2021. ⟨hal-03358351⟩
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