Karine HERAULT (EN)

NEURO-DOL – UMR1107 INSERM/UCA
2, rue de Braga, 63100, Clermont-Ferrand (FRANCE)

Karine HERAULT

Engineer
Team Trigeminal Pain and Migraine

karine.herault@-Code to remove to avoid SPAM-inserm.fr
+33 4 73 17 73 67, room 244

Biography:

From 2008 to 2013, I worked in the Neurophysiology and New Microscopies laboratory in the laboratory of Serge Charpak, in the Ropert/Oheim team. Since 2014, I have joined the Neuro Dol laboratory in Pr. Dallel’s team. I participate in various research projects of the team, in particular on the role of astrocytes in inflammatory skin hypersensitivity and migraine in rodents.

Technical skills:

SDS Page and WB
Cell culture (cell lines; murine neurons and astrocytes)
Immunolabeling (murine brain and marrow)
Analysis behavioral (chronic inflammatory, neuropathic and migraine pain model in rats)
Surgery
Microscopy (confocal and epifluorescence microscope)
Training for new arrivals

Functions:

Master Pro Physiology Cellular and Molecular Biology PBCM Poitiers (2007)
INSERM study engineer (2009)

Responsibilities:

Prevention and OHS Assistant
Member of the Animal Welfare Structure (SBEA)
GMO
Member of the CLAS INSERM office Auvergne Rhône Alpes

Image:

HAL Publications

Journal articles

2025

ref_biblio: Manon Dussol, Gisela da Silva Borges, Claudie Beaulieu, Hadir Ghorbel, Amélie Descheemaeker, et al.. Contribution of peripheral and central delta opioid receptors in the relief of migraine‐like headache in female and male rats. British Journal of Pharmacology, 2025, 182 (18), pp.4380-4399. ⟨10.1111/bph.70098⟩. ⟨hal-05281543⟩
Accès au bibtex

ref_biblio: Sarah Mountadem, Karine Hérault, Cedric Peirs, Gisela da Silva Borges, Daniel Voisin, et al.. Astrocytic Kir4.1 ion channel deficit drives persistent inflammatory facial pain in males. Brain – A Journal of Neurology , 2025, ⟨10.1093/brain/awaf122⟩. ⟨hal-05035061⟩
Accès au bibtex

2021

ref_biblio: Cuong Pham, Karine Hérault, Martin Oheim, Steeve Maldera, Vincent Vialou, et al.. Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca 2+ alteration and multiphasic transmitter release. Acta Neuropathologica Communications, 2021, 9 (1), pp.44. ⟨10.1186/s40478-021-01146-1⟩. ⟨hal-03182439⟩
Accès au texte intégral et bibtex

ref_biblio: Alexia Visseq, Amélie Descheemaeker, Karine Hérault, Francis Giraud, Isabelle Abrunhosa-Thomas, et al.. Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia. European Journal of Medicinal Chemistry, 2021, 225, pp.113748. ⟨10.1016/j.ejmech.2021.113748⟩. ⟨hal-03334145⟩
Accès au texte intégral et bibtex

2015

ref_biblio: Dongdong Li, Karine Hérault, Kathleen Zylbersztejn, Marcel A Lauterbach, Marc Guillon, et al.. Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking.. The Journal of Physiology, 2015, 593 (13), pp.2807-32. ⟨10.1113/JP270362⟩. ⟨hal-01266219⟩
Accès au bibtex

2014

ref_biblio: Maia Brunstein, Karine Hérault, Martin Oheim. Eliminating Unwanted Far-Field Excitation in Objective-Type TIRF. Part II. Combined Evanescent-Wave Excitation and Supercritical-Angle Fluorescence Detection Improves Optical Sectioning. Biophysical Journal, 2014, 106 (5), pp.1044-1056. ⟨10.1016/j.bpj.2013.12.051⟩. ⟨hal-04136748⟩
Accès au bibtex

ref_biblio: Maia Brunstein, Maxime Teremetz, Karine Hérault, Christophe Tourain, Martin Oheim. Eliminating Unwanted Far-Field Excitation in Objective-Type TIRF. Part I. Identifying Sources of Nonevanescent Excitation Light. Biophysical Journal, 2014, 106 (5), pp.1020-1032. ⟨10.1016/j.bpj.2013.12.049⟩. ⟨hal-04136747⟩
Accès au bibtex

2013

ref_biblio: Maia Brunstein, Kai Wicker, Karine Hérault, Rainer Heintzmann, Martin Oheim. Full-field dual-color 100-nm super-resolution imaging reveals organization and dynamics of mitochondrial and ER networks. Optics Express, 2013, 21 (22), pp.26162. ⟨10.1364/oe.21.026162⟩. ⟨hal-04136753⟩
Accès au bibtex

ref_biblio: Dongdong Li, Karine Herault, Kaetlin Silm, Alexis Evrard, Sonja Wojcik, et al.. Lack of Evidence for Vesicular Glutamate Transporter Expression in Mouse Astrocytes. Journal of Neuroscience, 2013, 33 (10), pp.4434-4455. ⟨10.1523/JNEUROSCI.3667-12.2013⟩. ⟨hal-01542733⟩
Accès au bibtex

2012

ref_biblio: Dongdong Li, Karine Hérault, Ehud Y Isacoff, Martin Oheim, Nicole Ropert. Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release. The Journal of Physiology, 2012, 590 (4), pp.855-873. ⟨10.1113/jphysiol.2011.219345⟩. ⟨hal-04700475⟩
Accès au bibtex

2009

ref_biblio: Dongdong Li, Karine Hérault, Nicole Ropert, Martin Oheim. FM dyes enter via a store-operated calcium channel and modify calcium signaling of cultured astrocytes. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (51), pp.21960-21965. ⟨10.1073/pnas.0909109106⟩. ⟨hal-04700452⟩
Accès au bibtex

Poster communications

2023

ref_biblio: P. Moreau, A. Visseq, A. Descheemaeker, N. Pinto-Pardo, K. Herault, et al.. Development of pyridin-2(1H)-one derivatives with in vivo activity toward mechanical allodynia.. 3rd RSC Anglo-Nordic Medicinal Chemistry Symposium, Jun 2023, Snekkersten, Denmark. ⟨hal-04563721⟩
Accès au bibtex

Preprints, Working Papers, …

2025

ref_biblio: Justine Loudan, Karine Herault, Tanguy Damart, Pauline Murail, Alexanne Michon, et al.. Sex-specific axon initial segment plasticity underlies cortical hyperexcitability in trigeminal pain. 2025. ⟨hal-05338933⟩
Accès au texte intégral et bibtex

ref_biblio: Ahmed Negm, François Gabrielli, Mickael Zbili, Louis Poncet-Megemont, Karine Herault, et al.. Sensory plasticity of dorsal horn silent neurons: a critical mechanism for neuropathic pain. 2025. ⟨hal-05336997⟩
Accès au texte intégral et bibtex