Giséla DA SILVA BORGES (EN)

NEURO-DOL – UMR1107 INSERM/UCA
2, rue de Braga, 63100, Clermont-Ferrand (FRANCE)

Dr. Giséla DA SILVA BORGES

Engineer
Team Trigeminal Pain and Migraine

gisela.da_silva_borges@-Code to remove to avoid SPAM-uca.fr
+33 4 73 17 73 67, room 244

Research Theme:

I study changes in the electrophysiological activity of Wide Dynamic Range (WDR) neurons in the trigeminal sensory complex as well as neurons in different brain regions in response to painful stimulation in the orofacial and periorbital regions. I also study how different pharmacological targets can act on these changes.

Techniques Used:

Extracellular electrophysiology, immunohistochemistry, stereotaxic surgery, viral manipulation.

Functions:

Design engineer

Responsibilities:

Responsible for medicines in the Dallel team laboratory.

Image:

HAL Publications

Journal articles

2025

ref_biblio: Manon Dussol, Gisela da Silva Borges, Claudie Beaulieu, Hadir Ghorbel, Amélie Descheemaeker, et al.. Contribution of peripheral and central delta opioid receptors in the relief of migraine‐like headache in female and male rats. British Journal of Pharmacology, 2025, 182 (18), pp.4380-4399. ⟨10.1111/bph.70098⟩. ⟨hal-05281543⟩
Accès au bibtex

ref_biblio: Sarah Mountadem, Karine Hérault, Cedric Peirs, Gisela da Silva Borges, Daniel Voisin, et al.. Astrocytic Kir4.1 ion channel deficit drives persistent inflammatory facial pain in males. Brain – A Journal of Neurology , 2025, ⟨10.1093/brain/awaf122⟩. ⟨hal-05035061⟩
Accès au bibtex

2020

ref_biblio: Meritxell Llorca-Torralba, Fuencisla Pilar-Cuéllar, Gisela da Silva Borges, Juan Mico, Esther Berrocoso. Opioid receptors mRNAs expression and opioids agonist-dependent G-protein activation in the rat brain following neuropathy. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 99, pp.109857. ⟨10.1016/j.pnpbp.2019.109857⟩. ⟨hal-04258370⟩
Accès au bibtex

2018

ref_biblio: Sonia Torres-Sanchez, Gisela da Silva Borges, Juan A Mico, Esther Berrocoso. Opioid and noradrenergic contributions of tapentadol to the inhibition of locus coeruleus neurons in the streptozotocin rat model of polyneuropathic pain. Neuropharmacology, 2018, 135, pp.202-210. ⟨10.1016/j.neuropharm.2018.03.014⟩. ⟨hal-04258391⟩
Accès au bibtex

2017

ref_biblio: Gisela da Silva Borges, Cristina Miguelez, Fani Neto, Juan Antonio Mico, Luisa Ugedo, et al.. Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats. International Journal of Neuropsychopharmacology, 2017, 20 (6), pp.463-475. ⟨10.1093/ijnp/pyx005⟩. ⟨hal-04258416⟩
Accès au texte intégral et bibtex

2016

ref_biblio: Meritxell Llorca-Torralba, Gisela Borges, Fani Neto, Juan Antonio Mico, Esther Berrocoso. Noradrenergic Locus Coeruleus pathways in pain modulation. Neuroscience, 2016, 338, pp.93-113. ⟨10.1016/j.neuroscience.2016.05.057⟩. ⟨hal-04258248⟩
Accès au bibtex

2015

ref_biblio: Gisela Patrícia Borges, Juan Antonio Micó, Fani Lourença Neto, Esther Berrocoso. Corticotropin-Releasing Factor Mediates Pain-Induced Anxiety through the ERK1/2 Signaling Cascade in Locus Coeruleus Neurons. International Journal of Neuropsychopharmacology, 2015, 18 (8), pyv019. ⟨10.1093/ijnp/pyv019⟩. ⟨hal-04329802⟩
Accès au texte intégral et bibtex

ref_biblio: Gisela Borges, Esther Berrocoso, Juan Antonio Mico, Fani Neto. ERK1/2: Function, signaling and implication in pain and pain-related anxio-depressive disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2015, 60, pp.77-92. ⟨10.1016/j.pnpbp.2015.02.010⟩. ⟨hal-04329814⟩
Accès au bibtex

2014

ref_biblio: Gisela Borges, Fani Neto, Juan Antonio Mico, Esther Berrocoso. Reversal of Monoarthritis-induced Affective Disorders by Diclofenac in Rats. Anesthesiology, 2014, 120 (6), pp.1476-1490. ⟨10.1097/ALN.0000000000000177⟩. ⟨hal-04337324⟩
Accès au bibtex

2012

ref_biblio: G.S. Borges, E. Berrocoso, A. Ortega-Alvaro, J.A. Mico, F.L. Neto. Extracellular signal‐regulated kinase activation in the chronic constriction injury model of neuropathic pain in anaesthetized rats. European Journal of Pain, 2012, 17 (1), pp.35-45. ⟨10.1002/j.1532-2149.2012.00181.x⟩. ⟨hal-04329830⟩
Accès au bibtex

2011

ref_biblio: Cristina Alba-Delgado, Gisela Borges, Pilar Sánchez-Blázquez, Jorge Ortega, Igor Horrillo, et al.. The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. Psychopharmacology, 2011, 221 (1), pp.53-65. ⟨10.1007/s00213-011-2542-7⟩. ⟨hal-04329835⟩
Accès au bibtex

ref_biblio: Fani L. Neto, Gisela Borges, Sonia Torres-Sanchez, Juan A. Mico, Esther Berrocoso. Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence. Current Neuropharmacology, 2011, 9 (4), pp.530-552. ⟨10.2174/157015911798376262⟩. ⟨hal-04329841⟩
Accès au bibtex

Conference papers

2023

ref_biblio: Pauline Murail, Amélie Descheemaeker, Gisela da Silva Borges, Nicolas Pinto-Pardo, Alexia Visseq, et al.. Pyridin-2(1H)one derivatives: A new class of therapeutics for trigeminal pain. International Headache Congress, Sep 2023, séoul, France. ⟨hal-04213873⟩
Accès au bibtex

Other publications

2018

ref_biblio: Gisela da Silva Borges, Ravi Shrivastava, Monika Rousse. The Discovery of VB-Gy Filmogen Glycerol Should Revolutionize Hemorrhoidal Treatment in the Future. 2018, pp.J Clin Trials Res, 1(1): 3-4. ⟨hal-04258463⟩
Accès au bibtex

Poster communications

2023

ref_biblio: Manon Dussol, Gisela da Silva Borges, Claudie Beaulieu, Philippe Luccarini, Louis Gendron, et al.. Implication of peripheral and central delta opioid receptors in migraine-like headache in rats. International Headache Congress, Sep 2023, SEOUL, France. ⟨hal-04246524⟩
Accès au bibtex