Cristina ALBA DELGADO (EN)
Faculté de Chirurgie Dentaire, 2 Rue de Braga – 63100 Clermont-Fd – (0)4 73 17 73 20
Service de Biophysique et Mathématiques Pharmaceutiques
6e étage, R2, Faculté de Pharmacie, 28 Place Henri Dunant – 63000 Clermont-Fd – (0)4 73 17 79 78
Dr. Cristina ALBA DELGADO
Assistant Professor
Team TPM – Pathophysiology of migraine axis, Team Trigeminal Pain and Migraine
Cristina.ALBA_DELGADO@-Code to remove to avoid SPAM-uca.fr
+33 4 73 17 73 20, room 246
Biography:
- 2021: Accreditation to Direct Research
- Since 2016 Lecturer – Clermont-Auvergne University, UMR 1107-Neuro-Dol
- 2013-2016: Post- doctorate – Clermont-Auvergne University, UMR 1107-Neuro-Dol
- 2009-2013: International Doctorate in Neuropharmacology – University of Cádiz (Spain)
- 2008-2010: DEA in Pharmacology – University of Cádiz (Spain)
- 2007: Degree in Biology – University of Sevilla (Spain)
Research Theme:
I am interested in the involvement of tryptophan metabolism (precursor of serotonin and kynurenine) and aryl hydrocarbon receptors (AhR) in: – the initiation and/or persistence of neuroinflammation at the system level central nervous system during the chronicization of migraine. – resistance to triptans in certain non-responder or partial responder migraine patients. I also study the mechanisms underlying photophobia associated with migraine.
Techniques Used:
Endomicroscopy associated with calcium imaging (Inscopix), immunohistochemistry and confocal microscopy, behavior (evaluation of pain, anxiety-depressive disorders, cognitive disorders), molecular biology (western blots, ELISA), electrophysiology.
Functions:
MCU-HDR
Teachings:
Applied biostatistics and modeling in health sciences and paramedical training, as well as neuroscience and biophysics, within the Department of Biophysics and Pharmaceutical Mathematics of the Faculty of Pharmacy.
Responsibilities:
- Licence 3 Science for Health, pharmacology and nutrition course: UE Analysis and Modeling
- Certificate of Orthoptics capacity: UE Scientific Method (2nd year)
- Speech therapy capacity certificate: EU Statistics 1 and 2 (2nd and 5th years)
- D.E. Occupational therapist: UE Introduction to the research process (3rd year)
Collaborations:
- University of the Basque Country (Spain), https://www.ehu.eus/en/en- home
- Spanish National Center for Cardiovascular Research (CNIC), https:// www.cnic.es/en/about-cnic-0
HAL Publications
Journal articles
2022
- ref_biblio
- Corinne El Khoueiry, Cristina Alba-Delgado, Myriam Antri, Maria Gutierrez-Mecinas, Andrew J. Todd, et al.. GABAA and Glycine Receptor-Mediated Inhibitory Synaptic Transmission onto Adult Rat Lamina IIi PKCγ-Interneurons: Pharmacological but not Anatomical Specialization. Cells, 2022, 11 (8), pp.1356. ⟨10.3390/cells11081356⟩. ⟨hal-03643239⟩
- Accès au texte intégral et bibtex
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- ref_biblio
- Noëmie Mermet-Joret, Cristina Alba-Delgado, Amélie Descheemaeker, Francois Gabrielli, Radhouane Dallel, et al.. Postnatal development of inner lamina II interneurons of the rat medullary dorsal horn. Pain, 2022, 163 (5), pp.984-998. ⟨10.1097/j.pain.0000000000002459⟩. ⟨hal-04487389⟩
- Accès au bibtex
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2021
- ref_biblio
- Cristina Alba-Delgado, Juan Antonio Mico, Esther Berrocoso. Neuropathic pain increases spontaneous and noxious-evoked activity of locus coeruleus neurons. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021, 105, pp.110121. ⟨10.1016/j.pnpbp.2020.110121⟩. ⟨hal-02980283⟩
- Accès au bibtex
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2018
- ref_biblio
- Cristina Alba-Delgado, Sarah Mountadem, Noémie Mermet-Joret, Lénaïc Monconduit, Radhouane Dallel, et al.. 5-HT 2A Receptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat. Journal of Neuroscience, 2018, 38 (49), pp.10489-10504. ⟨10.1523/JNEUROSCI.1294-18.2018⟩. ⟨hal-04326313⟩
- Accès au texte intégral et bibtex
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- ref_biblio
- Cristina Alba-Delgado, Meritxell Llorca-Torralba, Juan Antonio Mico, Esther Berrocoso. The onset of treatment with the antidepressant desipramine is critical for the emotional consequences of neuropathic pain. Pain, 2018, 159 (12), pp.2606-2619. ⟨10.1097/j.pain.0000000000001372⟩. ⟨hal-04264904⟩
- Accès au bibtex
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2016
- ref_biblio
- Cristina Alba-Delgado, Alberto Cebada-Aleu, Juan Antonio Mico, Esther Berrocoso. Comorbid anxiety-like behavior and locus coeruleus impairment in diabetic peripheral neuropathy: A comparative study with the chronic constriction injury model. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2016, 71, pp.45-56. ⟨10.1016/j.pnpbp.2016.06.007⟩. ⟨hal-04264911⟩
- Accès au bibtex
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2015
- ref_biblio
- Cristina Alba-Delgado, Corinne El Khoueiry, Cédric Peirs, Radhouane Dallel, Alain Artola, et al.. Subpopulations of PKCγ interneurons within the medullary dorsal horn revealed by electrophysiologic and morphologic approach. Pain, 2015, 156 (9), pp.1714-1728. ⟨10.1097/j.pain.0000000000000221⟩. ⟨hal-04326290⟩
- Accès au bibtex
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- ref_biblio
- Carmen Romero-Grimaldi, Esther Berrocoso, Cristina Alba-Delgado, Jose Luis M. Madrigal, Beatriz Perez-Nievas, et al.. Stress Increases the Negative Effects of Chronic Pain on Hippocampal Neurogenesis. Anesthesia & Analgesia, 2015, 121 (4), pp.1078-1088. ⟨10.1213/ANE.0000000000000838⟩. ⟨hal-04264915⟩
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2014
- ref_biblio
- Lidia Bravo, Sonia Torres-Sanchez, Cristina Alba-Delgado, Juan Mico, Esther Berrocoso. Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats. European Neuropsychopharmacology, 2014, 24 (6), pp.996-1003. ⟨10.1016/j.euroneuro.2014.01.011⟩. ⟨hal-04264924⟩
- Accès au bibtex
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2013
- ref_biblio
- Cristina Alba-Delgado, Meritxell Llorca-Torralba, Igor Horrillo, Jorge Ortega, Juan Antonio Mico, et al.. Chronic Pain Leads to Concomitant Noradrenergic Impairment and Mood Disorders. Biological Psychiatry, 2013, 73 (1), pp.54-62. ⟨10.1016/j.biopsych.2012.06.033⟩. ⟨hal-04264922⟩
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2011
- ref_biblio
- Cristina Alba-Delgado, Gisela Borges, Pilar Sánchez-Blázquez, Jorge Ortega, Igor Horrillo, et al.. The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. Psychopharmacology, 2011, 221 (1), pp.53-65. ⟨10.1007/s00213-011-2542-7⟩. ⟨hal-04329835⟩
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Conference papers
2022
- ref_biblio
- Yara Mrad, Anais Raoelina, Radhouane Dallel, Isabelle Ranchon-Cole, Cristina Alba-Delgado. Aryl hydrocarbon receptors are involved in the pathogenesis of migraine.. 16th European Headache Federation Congress, Dec 2022, Viena, Austria. ⟨hal-04265010⟩
- Accès au bibtex
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- ref_biblio
- Yara Mrad, Manon Meunier, Robin Lioutaud, Isabelle Ranchon-Cole, Cristina Alba-Delgado, et al.. Dietary tryptophan as a potential factor of migraine chronification.. International Headache and Pain symposium, Jul 2022, Clermont-Ferrand, France. ⟨hal-04265027⟩
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- ref_biblio
- Yara Mrad, Radhouane Dallel, Cristina Alba-Delgado. L’alimentation a-t-elle un rôle dans la chronicisation de la migraine ?. 22e Congrès National de la SFETD, Nov 2022, Lille, France. ⟨hal-04265016⟩
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2018
- ref_biblio
- Elise Thierry, Anne Bourgeot, Paul Avan, Radhouane Dallel, Isabelle Ranchon-Cole, et al.. Sex differences in light sensitivity in a mice model of migraine. 11th FENS Forum of Neuroscience, Jul 2018, Berlin, Germany. ⟨hal-02980303⟩
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Poster communications
2024
- ref_biblio
- Fabien Lesne, Amir Attallah, Anthony de Oliveira, Maryvonne Ardourel, Isabelle Ranchon-Cole, et al.. Rôle clé du gène Fmr1 dans la photophobie : du patient atteint du syndrome de l’X-Fragile au modèle murin. 12èmes Assises de Génétique Humaine et Médicale, Jan 2024, Paris, France. ⟨hal-04264971⟩
- Accès au bibtex
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2019
- ref_biblio
- Cristina Alba-Delgado, Marie Raquin, Mohamed Zkim, Christine Cercy, Paul Avan, et al.. Migraine-associated photophobia: A new mice model for light aversion study. IBRO World Congress, Sep 2019, Daegu, South Korea. , IBRO Reports, 6, pp.S374, 2019, ⟨10.1016/j.ibror.2019.07.1189⟩. ⟨hal-02980273⟩
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2018
- ref_biblio
- H Nguyen, Cristina Alba-Delgado, Radhouane Dallel, Myriam Antri, Alain Artola. CFA-induced facial mechanical allodynia is associated with long-term synaptic potentiation and neuronal hyperexcitability but short-term metaplasticity in layer II/III primary somatosensory cortex.. XIVème Symposium National du Réseau Français de Recherche sur la Douleur, Mar 2018, Toulouse, France. ⟨hal-04265045⟩
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Proceedings
2022
- ref_biblio
- Yara Mrad, Anais Raoelina, Radhouane Dallel, Isabelle Ranchon-Cole, Cristina Alba-Delgado. Aryl hydrocarbon receptors are involved in the pathogenesis of migraine. Journal of Headache and Pain, 23 (S1), pp.163, 2022, ⟨10.1186/s10194-022-01527-4⟩. ⟨hal-04271876⟩
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