Cedric PEIRS (EN)

NEURO-DOL – UMR1107 INSERM/UCA
2, rue de Braga, 63100, Clermont-Ferrand (FRANCE)

Dr. Cedric PEIRS

Principal Investigator
Team TPM – Pathophysiology of mechanical allodynia axis, Team Trigeminal Pain and Migraine

cedric.peirs@-Code to remove to avoid SPAM-inserm.fr
+33(0)4-7317-7311, room 245

Students :

Alice GILBERT
Anais LEGRAND

Biography:

PhD. in Neurosciences ( University of Auvergne)
Master’s degree in Cellular Biology and Pathophysiology (University of Bordeaux / University of Melbourne)
Bachelor’s degree in Cellular Biology and Physiology (University of Bordeaux)

Research Theme:

– Axis Pathophysiology of mechanical allodynia –
My research focuses on the neurobiology of pain, in particular on the neural circuits of the dorsal horn of the spinal cord and the trigeminal sensory complex underlying chronic pain.

Techniques Used:

Electrophysiology (Patch Clamp)
Microscopy (electron, confocal, 2-photons)
Calcium imaging, Fiber-photometry
Opto/chemo-genetics

Functions:

Principal Investigator – CRCN Inserm

Teachings:

UCA UE 018 M2 Medicine Sciences: “Methods and Models in Neuroscience”
ED SVSAE Modules “Discovery of microscopy”, “Design a microscopy plan” and “Analysis of microscopy images”

Responsibilities:

INSERM representative at UCA PARTNER since 2017
Member of the council of UMR Neuro-Dol since 2017
Member of the UCA HRS4R steering committee since 2018
Member of the Research commission of the French Society for the Study and Treatment of Pain (SFETD) since 2022
Team Representative for UCA international partnerships since 2022
Ambassador to Clermont Auvergne Innovation (CAI) since 2022

Collaborations:

Reza Sharif-Naeini (McGill, Canada) https://www.shariflab.org/ourteam
Victoria Abraira (Rutgers, USA) https://www.abrairalab.org
Gilles Marodon (Paris, France) https://cimiparis.fr/equipes/dieu-nosjean-marie-caroline
Daniel Voisin (Bordeaux, France) https://www.bordeaux-neurocampus.fr/staff/daniel-voisin

Image:

Anecdote:

Likes: Sushi
Dislikes: 50 Hz noise

HAL Publications

Journal articles

2025

ref_biblio: Matthew Mannarino, Hosni Cherif, Saber Ghazizadeh, Oliver Wu Martinez, Kai Sheng, et al.. Senolytic treatment for low back pain. Science Advances , 2025, 11 (11), pp.adr1719. ⟨10.1126/sciadv.adr1719⟩. ⟨hal-04993847⟩
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ref_biblio: Sarah Mountadem, Karine Hérault, Cedric Peirs, Gisela da Silva Borges, Daniel Voisin, et al.. Astrocytic Kir4.1 ion channel deficit drives persistent inflammatory facial pain in males. Brain – A Journal of Neurology , 2025, ⟨10.1093/brain/awaf122⟩. ⟨hal-05035061⟩
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2024

ref_biblio: Nicolas Aubert, Madeleine Purcarea, Julien Novarino, Julien Schopp, Alexis Audibert, et al.. Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice. eLife, 2024, 13, pp.eLife.91359. ⟨10.7554/eLife.91359⟩. ⟨hal-04678921⟩
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ref_biblio: Nathan Moreau, Cédric Peirs, Radhouane Dallel, Yves Boucher. Spécificités de la douleur neuropathique oro-faciale. Médecine/Sciences, 2024, 40 (1), pp.64 – 71. ⟨10.1051/medsci/2023197⟩. ⟨hal-04438162⟩
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ref_biblio: Nathan Moreau, Cédric Peirs, Radhouane Dallel, Yves Boucher. Spécificités de la douleur neuropathique oro-faciale. Médecine/Sciences, 2024, 40 (1), pp.64-71. ⟨10.1051/medsci/2023197⟩. ⟨hal-04433402⟩
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2022

ref_biblio: Sylvain Mathieu, Martin Soubrier, Cedric Peirs, Laurent-Emmanuel Monfoulet, Yves Boirie, et al.. A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms. Nutrients, 2022, 14 (8), pp.1607. ⟨10.3390/nu14081607⟩. ⟨hal-03736597⟩
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2021

ref_biblio: Cedric Peirs, Sean-Paul G G Williams, Xinyi Zhao, Cynthia M Arokiaraj, David W Ferreira, et al.. Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury. Neuron, 2021, 109, pp.1 – 18. ⟨10.1016/j.neuron.2020.10.027⟩. ⟨inserm-03001339⟩
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2020

ref_biblio: Cedric Peirs, Radhouane Dallel, Andrew J Todd. Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia. Journal of Neural Transmission, 2020, 127 (4), pp.505-525. ⟨10.1007/s00702-020-02159-1⟩. ⟨inserm-02701538⟩
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2016

ref_biblio: Cedric Peirs, Nathalie Bourgois, Alain Artola, Radhouane Dallel. PKCγ Interneurons Mediate C-Fiber-Induced Orofacial Secondary Static Mechanical
Allodynia, but not C-Fiber-Induced Nociceptive Behavior. Anesthesiology, 2016, 124 (5), pp.1136-1152. ⟨10.1097/ALN.0000000000001000⟩. ⟨hal-04412813⟩
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ref_biblio: Cedric Peirs, Rebecca Seal. Neural circuits for pain: recent advances and current views. Science, 2016, 354 (6312), pp.578-584. ⟨10.1126/science.aaf8933⟩. ⟨hal-04412766⟩
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ref_biblio: Cedric Peirs, Nathalie Bourgois, Alain Artola, Radhouane Dallel. Protein Kinase C γ Interneurons Mediate C-fiber–induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber–induced Nociceptive Behavior. Anesthesiology, 2016, 124 (5), pp.1136-1152. ⟨10.1097/ALN.0000000000001000⟩. ⟨hal-03126323⟩
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2015

ref_biblio: Cristina Alba-Delgado, Corinne El Khoueiry, Cédric Peirs, Radhouane Dallel, Alain Artola, et al.. Subpopulations of PKCγ interneurons within the medullary dorsal horn revealed by electrophysiologic and morphologic approach. Pain, 2015, 156 (9), pp.1714-1728. ⟨10.1097/j.pain.0000000000000221⟩. ⟨hal-04326290⟩
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ref_biblio: Cedric Peirs, Sean-Paul G Williams, Xinyi Zhao, Claire E Walsh, Jeremy Y Gedeon, et al.. Dorsal Horn Circuits for Persistent Mechanical Pain. Neuron, 2015, 87 (4), pp.797 – 812. ⟨10.1016/j.neuron.2015.07.029⟩. ⟨hal-04400758⟩
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ref_biblio: Cedric Peirs, Rebecca Seal. Targeting Toll-like receptors to treat chronic pain. Nature Medicine, 2015, 21 (11), pp.1251-1252. ⟨10.1038/nm.3986⟩. ⟨hal-04400819⟩
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2014

ref_biblio: Cédric Peirs, Sudarshan Patil, Rabia Bouali-Benazzouz, Alain Artola, Marc Landry, et al.. Protein kinase C gamma interneurons in the rat medullary dorsal horn: distribution and synaptic inputs of these neurons, and subcellular localization of the enzyme. Journal of Comparative Neurology, 2014, 522 (2), pp.393-413. ⟨10.1002/cne.23407⟩. ⟨hal-04412846⟩
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2011

ref_biblio: Loïs S Miraucourt, Cédric Peirs, Radhouane Dallel, Daniel L Voisin. Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. Pain, 2011, 152 (6), pp.1340 – 1348. ⟨10.1016/j.pain.2011.02.021⟩. ⟨hal-04412880⟩
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Conference papers

2023

ref_biblio: Cedric Peirs. Advances in signaling and treatments of inflammatory pain syndromes. NeuroFrance 2023, May 2023, Lyon, France. ⟨hal-04412407⟩
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ref_biblio: Cedric Peirs. Plasticity of sensory processing by spinal dorsal horn neurons after neuropathy. Montreal Conference on Pain Circuit, Jul 2023, Montréal Québec, Canada. ⟨hal-04412400⟩
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ref_biblio: Cedric Peirs. Microcircuits underlying inflammatory versus neuropathic pain. NeuroFrance 2023, May 2023, Lyon, France. ⟨hal-04412439⟩
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2022

ref_biblio: Cedric Peirs. Understanding dorsal horn circuits mediating mechanical allodynia. McGill University seminar series, Sep 2022, Montréal, Canada. ⟨hal-04412446⟩
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2021

ref_biblio: Cedric Peirs. Mare de souffrir, mais que font les chercheurs ?!. Semaine du cerveau 2021, Mar 2021, Clermont-Ferrand, France. ⟨hal-04412587⟩
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ref_biblio: Cedric Peirs. Heterogeneity in Dorsal Horn Circuits that Mediate Persistent Pain. Pain 2021 Workshop: Genetic Interrogation of Spinal Cord Circuits, Jun 2021, Houston, United States. ⟨hal-04412468⟩
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ref_biblio: Cedric Peirs. Analysis of dorsal horn pain circuits through two-photon imaging. 6th symposium of microscopy of Clermont-Ferrand, Oct 2021, Clermont-Ferrand, France. ⟨hal-04412459⟩
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ref_biblio: Cedric Peirs. Heterogeneity of Pain within the Dorsal Horn. Universitätsklinikum Aachen – Physiologisches Kolloquium, Jul 2021, Aachen, Germany. ⟨hal-04412464⟩
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ref_biblio: Cedric Peirs. Pain in the dorsal horn: network or circuits?. International Workshop on Chronic Pain and Itch: Mechanisms and Circuits, Oct 2021, Alicante, Spain. ⟨hal-04412453⟩
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2019

ref_biblio: Cedric Peirs. Plus bête qu’hier et bien moins que demain. Semaine du cerveau 2019, Mar 2019, Clermont-Ferrand, France. ⟨hal-04412590⟩
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2018

ref_biblio: Cedric Peirs. Distinct neuronal circuits to turn touch into pain. Mini – Symposium IGF: Neuronal Circuits in Pain & Development, Nov 2018, Montpellier, France. ⟨hal-04412488⟩
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ref_biblio: Cedric Peirs. Unravelling Spinal Circuits Underlying Chronic Pain. The 17th world congress on pain, Sep 2018, Boston, United States. ⟨hal-04412501⟩
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ref_biblio: Cedric Peirs. Optogénétique et chémogénétique pour contrôler la douleur. Workshop Analgesia, Apr 2018, Clermont-Ferrand, France. ⟨hal-04412507⟩
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ref_biblio: Cedric Peirs. Identifying the Central Circuits for Mechanical Pain. XIVth National Symposium of the French Consortium of Pain Research, Mar 2018, Toulouse, France. ⟨hal-04412642⟩
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ref_biblio: Cedric Peirs. Distinct neuronal circuits mediate mechanical allodynia. Workshop Neurex, Oct 2018, Strasbourg, France. ⟨hal-04412495⟩
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ref_biblio: Cedric Peirs. Pain Circuits: Newly Discovered Networks Underlie Pain Symptoms And Dimensions. The 17th world congress on pain, Sep 2018, Boston, United States. ⟨hal-04412687⟩
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2017

ref_biblio: Cedric Peirs. Spinal cord networks underlying mechanical allodynia. French Society for Research and Treatment of Pain, Nov 2017, Nice, France. ⟨hal-04412516⟩
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ref_biblio: Cedric Peirs. The Neuronal Circuit that Turns Touch into Pain. Les Mardi du GReD, Nov 2017, Clermont-Ferrand, France. ⟨hal-04412514⟩
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ref_biblio: Cedric Peirs. The Spinal Cord Circuits for Chronic Pain. Neurofrance 2017, May 2017, Bordeaux, France. ⟨hal-04412524⟩
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2014

ref_biblio: Cedric Peirs. The Spinal Cord Circuit that Turns Touch into Pain. Postdoc-to-Postdoc, Dec 2014, Pittsburgh, United States. ⟨hal-04412532⟩
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ref_biblio: Cedric Peirs. A Critical Role for the Vesicular Glutamate Transporter 3 in Central Mechanical Pain Circuits. Neurobiology of Pain and Itch, Apr 2014, San Francisco, United States. ⟨hal-04412538⟩
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2012

ref_biblio: Cedric Peirs. Segmental mechanisms of trigeminal mechanical allodynia: the role of Reactive Oxygen Species (ROS). 8th Annual Symposium of the INSERM research network on Pain, Mar 2012, Clermont-Ferrand, France. ⟨hal-04412550⟩
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ref_biblio: Cedric Peirs. How can touch turn into pain: PKCγ neurons. Doctoral school symposium, May 2012, Clermont-Ferrand, France. ⟨hal-04412546⟩
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2011

ref_biblio: Cedric Peirs. Between touch and pain: PKCγ interneurons. 7th Research Day, Dec 2011, Clermont-Ferrand, France. ⟨hal-04412557⟩
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2009

ref_biblio: Cedric Peirs. Does the RLX3/RXFP3 system in the lateral hypothalamic area (LHA) influence circadian food anticipatory activity (FAA) in rats?. Relaxin symposium, May 2009, Melbourne, Australia. ⟨hal-04412564⟩
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Poster communications

2024

ref_biblio: N Aubert, M Purcarea, N Novarino, J Schopp, A Audibert, et al.. Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice. 7th European Congress of Immunology, Sep 2024, Dublin, Ireland. ⟨hal-04589310⟩
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ref_biblio: A Gilbert, L Miraucourt, M Georgiopoulos, I Colmegna, J Ouellet, et al.. Evaluating a novel target in the treatment of osteoarthritis pain. 27th Day of doctoral school SVSAE, May 2024, Clermont- Ferrand, France. ⟨hal-04589446⟩
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ref_biblio: A Gilbert, L Rabiller, L Miraucourt, M Georgiopoulos, I Colmegna, et al.. Evaluating a novel target in the treatment of osteoarthritis pain. McGill Pain Day, Jan 2024, Montréal, Canada. ⟨hal-04424974⟩
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2023

ref_biblio: A Gilbert, L Miraucourt, M Georgiopoulos, I Colmegna, J Ouellet, et al.. Evaluation of TACAN as a new target for treating osteoarthritis pain. 9th Mediterranean Neuroscience Society (MNS) Conference, Oct 2023, Carthage, Tunisia. ⟨hal-04412913⟩
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ref_biblio: A Gilbert, L Rabiller, L Miraucourt, M Georgiopoulos, I Colmegna, et al.. Evaluation of TACAN as a new target for treating osteoarthritis pain. McGill Pain Day, Jan 2023, Montréal, Canada. ⟨hal-04412927⟩
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2022

ref_biblio: A Negm, F Gabrielli, R Dallel, Cedric Peirs. Revealing dorsal horn circuits through 2-photon calcium imaging. The 2022 world congress on pain, Sep 2022, Toronto, Canada. ⟨hal-04412943⟩
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2021

ref_biblio: J Makhoul, S Mountadem, A Artola, R Dallel, Cedric Peirs. How Does Kir4.1 turn Touch into Pain?. 24th Day of doctoral school SVSAE, May 2021, Clermont-Ferrand, France. ⟨hal-04412957⟩
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ref_biblio: A Negm, F Gabrielli, J Makhoul, A Artola, R Dallel, et al.. Revealing dorsal horn circuits through 2-photon calcium imaging. International Workshop on Chronic Pain and Itch: Mechanisms and Circuits, Oct 2021, Alicante, Spain. ⟨hal-04412950⟩
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2020

ref_biblio: S Mountadem, Cedric Peirs, K Herault, M Antri, R Dallel. Astroglial Kir4.1 ion channel deficit underlies inflammatory mechanical allodynia. French Society for Research and Treatment of Pain, Mar 2020, Bordeaux, France. ⟨hal-04412965⟩
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2019

ref_biblio: J Makhoul, L Poncet-Megemont, K Herault, A Descheemaeker, F Gabrielli, et al.. Identifying Central Circuits for Mechanical Pain. I-site CAP20-25 – Séminaire annuel du Challenge 3, Jan 2019, Clermont-Ferrand, France. ⟨hal-04412977⟩
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2017

ref_biblio: Cedric Peirs, Sp Williams, X Zhao, Ce Walsh, J Gedeon, et al.. The Spinal Cord Circuits For Chronic Pain. Neurofrance 2017, May 2017, Bordeaux, France. ⟨hal-04413001⟩
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ref_biblio: Cedric Peirs, X Zhao, Sp Williams, J Gedeon, Rp Seal. Neural Circuits for Mechanical Allodynia in the Spinal Cord Dorsal Horn. Annual Meeting Society for Neuroscience, Nov 2017, Washington, United States. ⟨hal-04412984⟩
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2015

ref_biblio: J Gedeon, Cedric Peirs, Sp Williams, X Zhao, P Marell, et al.. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Midwest/Great Lakes Undergraduate Research Symposium in Neuroscience, Oct 2015, Colombus, United States. ⟨hal-04413025⟩
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ref_biblio: Cedric Peirs, Sp Williams, X Zhao, J Gedeon, P Marell, et al.. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Barriers to Translation of Pain Research, Jun 2015, Pittsburgh, United States. ⟨hal-04413019⟩
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ref_biblio: Cedric Peirs, Sp Williams, X Zhao, J Gedeon, Rp Seal. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Data and Dine, May 2015, Pittsburgh, United States. ⟨hal-04413009⟩
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ref_biblio: Cedric Peirs, Sp Williams, X Zhao, J Gedeon, Rp Seal. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Annual Meeting Society for Neuroscience, Oct 2015, Chicago, United States. ⟨hal-04413028⟩
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ref_biblio: X Zhao, Cedric Peirs, Sp Williams, Rp Seal. Chemogenetic approach to study central mechanical pain circuits. 4th Annual Joint Scientific Pitt-Tsinghua Symposium, May 2015, Pittsburgh, United States. ⟨hal-04413016⟩
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2014

ref_biblio: Cedric Peirs, Sp Williams, Ce Walsh, Z Liu, Ne Cagle, et al.. A Critical Role for the Vesicular Glutamate Transporter 3 in Central Mechanical Pain Circuits. Annual Meeting Society for Neuroscience, Nov 2014, Washington, United States. ⟨hal-04413030⟩
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2012

ref_biblio: Cedric Peirs, S Patil, M Landry, A Artola, R Dallel. Organization and anatomical properties of Protein Kinase C gamma interneurons in the medullary dorsal horn. 8th FENS Forum of Neuroscience, Jul 2012, Barcelona, Spain. ⟨hal-04413035⟩
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2011

ref_biblio: Cedric Peirs, N Pham-Dang, A Artola, R Dallel. Activation of protein kinase C in the medullary dorsal horn produces mechanical hypersensitivity through superficial laminae nociceptive-specific NK1 receptor-negative neurons. 10th Colloque of the French Neuroscience Society, May 2011, Marseille, France. ⟨hal-04413053⟩
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ref_biblio: Cedric Peirs, A Descheemaeker, A Artola, R Dallel. How can touch become pain: the short-circuit PKCγ. Doctoriales 2011, Jun 2011, Saint-Nectaire, France. ⟨hal-04413042⟩
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Theses

2012

ref_biblio: Cédric Peirs. Mécanismes segmentaires de l’allodynie mécanique statique trigéminale : rôle des dérivés réactifs de l’oxygène (ROS), de la désinhibition GABAergique et des interneurones PKCγ. Neurosciences [q-bio.NC]. Université d’Auvergne – Clermont-Ferrand I, 2012. Français. ⟨NNT : 2012CLF1DD03⟩. ⟨tel-04498186⟩
Accès au texte intégral et bibtex