Jérôme BUSSEROLLES (EN)
UMR 1107 INSERM/UCA Neuro-Dol
Facultés de Médecine et Pharmacie
Place Henri Dunant
63001 Clermont-Ferrand
FRANCE
Dr. Jérôme BUSSEROLLES
Assistant Professor
Fundamental Pharmacology and Pain Clinic Team, Team FPPC – Pain and Cancer Axis
Jerome.BUSSEROLLES@-Code to remove to avoid SPAM-uca.fr
+33(0)4-7317-8235
Student :
Research Theme:
Within the Medical Pharmacology and Clinical Pain team, I am currently working on a better understanding of the pathophysiology of cancer pain (chemo-induced neuropathies by anticancer drugs and, more recently, bone pain from cancer metastases). The recent data that we have obtained suggest in particular that (i) epigenetic mechanisms participate in the development of neuropathies induced by oxaliplatin (Pereira et al., 2021; Lamoine et al., 2021), (ii) riluzole, a non-active activator selective for the TREK-1 channel, could have a preventive effect on the development of neuropathies induced by oxaliplatin (reference treatment for colorectal cancer) (Poupon et al., 2018) as well as in the development of metastatic bone pain (Delanne-Cuménal et al., 2024); a clinical study funded by a PHRC-K obtained in 2016 is notably underway to evaluate this hypothesis in cancer patients treated with oxaliplatin (Kerckhove et al., 2019); (iii) modulation of the function of HCN channels by disrupting their interaction with TRIP8b (neuronal partner protein, absent from cardiac tissue) could have an analgesic effect in these same pain models (collaborations with E.Bourinet, IGF, and with D .Chetkovich, Nashville, TN, USA). A collaboration with the ICCF COM team (C. Taillefumier) allowed us to show that peptoids (synthetic oligomers mimicking peptides) targeting this interaction have a functional effect in vitro and an analgesic effect in vivo in the same animal model. On the technical side, we recently initiated work using human iPS cells with the aim of developing a cellular model for the co-culture of sensory neurons and Schwann cells.
Teachings:
Responsible for 3 teaching modules in BUT Biological Engineering (Clermont-Ferrand): R3.BMB.10; R4.BMB.7; SAE 3.BMB.02. Since 2004, I have directed or co-directed 9 M2 and 10 doctoral students, including 2 in progress:
- Javier Megias-Vericat, “study of intestinal inflammation” 2004-2005
- Stéphane Lolignier, “Role of the sodium channel Nav1.9 in inflammatory pain, in the perception of cold and in hypersensitivity to cold induced by oxaliplatin” 2007-2011
- Maïly Devilliers, “Le canal TREK-1 potassium: a molecular target of interest for the development of effective and well-tolerated analgesics” 2009-2013
- Vanessa Pereira, “Involvement of TREK and TRAAK potassium channels in the pathophysiology of pain” 2010-2013
- Laura Poupon, “Study of functional couplings between class III metabotropic glutamate receptors and TREK and TRAAK potassium channels and their consequences in the pharmacology of pain” 2012-2015
- Sylvain Lamoine, “Study of the effects of HDAC inhibitors on neuropathy and the antiproliferative effect induced by oxaliplatin” 2014-2017
- Mélissa Cuménal, “Research into the involvement of group III metabotropic glutamate receptors in bone pain » 2017-2020
- Margaux Morez, « Modulation of HCN channel activity: Towards an innovative and well-tolerated therapeutic strategy against neuropathy induced by oxaliplatin » 2019-2022
- Romane Boyer, “Study of the role of TREK1 channels in the pathophysiology of pain and development of TREK1 activators from an analgesic perspective” 2021-2023
- Morgan Lété, “Characterization and use of human sensory neurons derived from induced pluripotent cells to model peripheral neuropathies linked to chemotherapy” 2023-2026
Responsibilities:
- Head of team 1 of UMR1107
- Member of the council of UMR 1107
- Member of the Ethics Committee on Animal Experimentation Auvergne
- Member of the SBEA and of the Management Council of the Animal Stabilization Unit of the Faculty of Medicine
- Member of the steering committee of the “organoid” platform of the UCA
Additional Information:
ORCID: 0000 – 0003 – 1592 – 2369
Web of Science ResearcherID: K-2204-2015
Web of Science ResearcherID: K-2204-2015
HAL Publications
Journal articles
2024
- ref_biblio
- Mélissa Delanne-Cuménal, Sylvain Lamoine, Mathieu Meleine, Youssef Aissouni, Laetitia Prival, et al.. The TREK-1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain. Biomedicine and Pharmacotherapy, 2024, 176, pp.116887. ⟨10.1016/j.biopha.2024.116887⟩. ⟨hal-04687342⟩
- Accès au texte intégral et bibtex
-
2023
- ref_biblio
- David Balayssac, Julie Durif, Céline Lambert, Cristelle Dalbos, Eric Chapuy, et al.. Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine. Toxics, 2023, 11 (12), pp.1004. ⟨10.3390/toxics11121004⟩. ⟨hal-04332718⟩
- Accès au texte intégral et bibtex
-
2022
- ref_biblio
- Sylvain Lamoine, Mélissa Cumenal, David Barriere, Vanessa Pereira, Mathilde Fereyrolles, et al.. The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice. International Journal of Molecular Sciences, 2022, 23 (1), pp.98. ⟨10.3390/ijms23010098⟩. ⟨hal-03703118⟩
- Accès au texte intégral et bibtex
-
2021
- ref_biblio
- Nicolas Kerckhove, Marie Selvy, Céline Lambert, Coralie Gonneau, Gabrielle Feydel, et al.. Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy. Frontiers in Pharmacology, 2021, 12, pp.1-10. ⟨10.3389/fphar.2021.744085⟩. ⟨hal-03498040⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Vanessa Pereira, Sylvain Lamoine, Mélissa Cuménal, Stéphane Lolignier, Youssef Aissouni, et al.. Epigenetics Involvement in Oxaliplatin-Induced Potassium Channel Transcriptional Downregulation and Hypersensitivity. Molecular Neurobiology, 2021, 58 (7), pp.3575-3587. ⟨10.1007/s12035-021-02361-6⟩. ⟨hal-03511787⟩
- Accès au bibtex
-
- ref_biblio
- Marie Selvy, Bruno Pereira, Nicolas Kerckhove, Jérôme Busserolles, Fadila Farsi, et al.. Prevention, diagnosis and management of chemotherapy-induced peripheral neuropathy: a cross-sectional study of French oncologists’ professional practices. Supportive Care in Cancer, 2021, 29 (7), pp.4033-4043. ⟨10.1007/s00520-020-05928-6⟩. ⟨hal-03299953⟩
- Accès au bibtex
-
- ref_biblio
- Marie Selvy, Nicolas Kerckhove, Bruno Pereira, Fantine Barreau, Daniel Nguyen, et al.. Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study. Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.637593⟩. ⟨hal-03238418⟩
- Accès au texte intégral et bibtex
-
2020
- ref_biblio
- Jérôme Busserolles, Stéphane Lolignier, Nicolas Kerckhove, Célian Bertin, Nicolas Authier, et al.. Replacement of current opioid drugs focusing on MOR-related strategies. Pharmacology and Therapeutics, 2020, 210, pp.107519. ⟨10.1016/j.pharmthera.2020.107519⟩. ⟨hal-03490336⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Jérôme Busserolles, Ismail Ben Soussia, Laetitia Pouchol, Nicolas Marie, Mathieu Meleine, et al.. TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects. British Journal of Pharmacology, 2020, 177 (20), pp.4782-4795. ⟨10.1111/bph.15243⟩. ⟨hal-03512213⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Mélissa Cuménal, Marie Selvy, Nicolas Kerckhove, Célian Bertin, Margaux Morez, et al.. The Safety of Medications used to Treat Peripheral Neuropathic Pain, Part 2 (Opioids, Cannabinoids and Other Drugs): review of Double-Blind, Placebo-Controlled, Randomized Clinical Trials. Expert Opinion on Drug Safety, 2020, pp.1-18. ⟨10.1080/14740338.2021.1842871⟩. ⟨hal-02997543⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Dimitra Gkika, Stéphane Lolignier, Guillaume Grolez, Alexis Bavencoffe, Georges Shapovalov, et al.. Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity. FASEB Journal, 2020, 34 (6), pp.7483-7499. ⟨10.1096/fj.201902270R⟩. ⟨hal-03512394⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Marie Selvy, Mélissa Cuménal, Nicolas Kerckhove, Christine Courteix, Jérôme Busserolles, et al.. The safety of medications used to treat peripheral neuropathic pain, part 1 (antidepressants and antiepileptics): review of double-blind, placebo-controlled, randomized clinical trials. Expert Opinion on Drug Safety, 2020, 19 (6), pp.707-733. ⟨10.1080/14740338.2020.1764934⟩. ⟨hal-02997564⟩
- Accès au texte intégral et bibtex
-
2019
- ref_biblio
- David André Barrière, Al Mahdy Hamieh, Ricardo Magalhães, Amidou Traore, Julie Barbier, et al.. Structural and functional alterations in the retrosplenial cortex following neuropathic pain. Pain, 2019, 160 (10), pp.2241-2254. ⟨10.1097/j.pain.0000000000001610⟩. ⟨hal-04327523⟩
- Accès au bibtex
-
- ref_biblio
- Nicolas Kerckhove, Jérôme Busserolles, Trevor Stanbury, Bruno Pereira, Valérie Plence, et al.. Effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy: RILUZOX-01: protocol of a randomised, parallel, controlled, double-blind and multicentre study by the UNICANCER-AFSOS Supportive Care intergroup. BMJ Open, 2019, 9 (6), pp.e027770. ⟨10.1136/bmjopen-2018-027770⟩. ⟨hal-02325112⟩
- Accès au texte intégral et bibtex
-
2018
- ref_biblio
- Laura Poupon, Sylvain Lamoine, Vanessa Pereira, David Barriere, Stéphane Lolignier, et al.. Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. Neuropharmacology, 2018, 140, pp.43-61. ⟨10.1016/j.neuropharm.2018.07.026⟩. ⟨hal-02065469⟩
- Accès au texte intégral et bibtex
-
2017
- ref_biblio
- Delphine Vivier, Ismail Ben Soussia, Nuno Rodrigues, Stéphane Lolignier, Maïly Devilliers, et al.. Development of the First Two-Pore Domain Potassium Channel TWIK-Related K + Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity. Journal of Medicinal Chemistry, 2017, 60 (3), pp.1076-1088. ⟨10.1021/acs.jmedchem.6b01285⟩. ⟨hal-02390407⟩
- Accès au bibtex
-
2016
- ref_biblio
- Stéphane Lolignier, Dimitra Gkika, David Andersson, Enrico Leipold, Irina Vetter, et al.. New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives. Journal of Neuroscience, 2016, 36 (45), pp.11435 – 11439. ⟨10.1523/jneurosci.2327-16.2016⟩. ⟨hal-03512571⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Stéphane Lolignier, Alain Eschalier, Caroline Bonnet, Patrick Delmas, Jérôme Busserolles. Le canal Nav1.9 : protéine clé pour la perception du froid et cible thérapeutique potentielle contre la douleur. Médecine/Sciences, 2016, 32 (2), pp.162 – 165. ⟨10.1051/medsci/20163202009⟩. ⟨hal-01795185⟩
- Accès au texte intégral et bibtex
-
2015
- ref_biblio
- Stéphane Lolignier, Caroline Bonnet, Christelle Gaudioso, Jacques Noël, Jérôme Ruel, et al.. The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia. Cell Reports, 2015, ⟨10.1016/j.celrep.2015.04.027⟩. ⟨hal-01208540⟩
- Accès au texte intégral et bibtex
-
2014
- ref_biblio
- Nuno Rodrigues, Khalil Bennis, Delphine Vivier, Vanessa Pereira, Franck C. Chatelain, et al.. Synthesis and structure-activity relationship study of substituted caffeateesters as antinociceptive agents modulating the TREK-1 channel.. European Journal of Medicinal Chemistry, 2014, 75, pp.391-402. ⟨hal-00955551⟩
- Accès au bibtex
-
2013
- ref_biblio
- Maïly Devilliers, Jérôme Busserolles, Stéphane Lolignier, Emmanuel Deval, Vanessa Pereira, et al.. Activation of TREK-1 by morphine results in analgesia without adverse side effects. Nature Communications, 2013, 4, ⟨10.1038/ncomms3941⟩. ⟨hal-01689367⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Bruno Vilar, Jérôme Busserolles, Bing Ling, Sophie Laffray, Lauriane Ulmann, et al.. Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor. Journal of Neuroscience, 2013, 33 (48), pp.18951-18965. ⟨10.1523/JNEUROSCI.1221-13.2013⟩. ⟨hal-02448295⟩
- Accès au texte intégral et bibtex
-
2012
- ref_biblio
- David André Barrière, Jennifer Rieusset, Didier Chanteranne, Jérôme Busserolles, Marie-Agnès Chauvin, et al.. Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization. Pain, 2012, 153 (3), pp.553 – 561. ⟨10.1016/j.pain.2011.11.019⟩. ⟨hal-02645150⟩
- Accès au bibtex
-
2011
- ref_biblio
- Juliette Descoeur, Vanessa Pereira, Anne Pizzoccaro, Amaury François, Bing Ling, et al.. Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Molecular Medicine, 2011, 3 (5), pp.266-278. ⟨10.1002/emmm.201100134⟩. ⟨hal-02370551⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Stéphane Lolignier, Muriel Amsalem, François Maingret, Françoise Padilla, Mélanie Gabriac, et al.. Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation. PLoS ONE, 2011, 6 (8), pp.23083. ⟨10.1371/journal.pone.0023083⟩. ⟨hal-01689907⟩
- Accès au texte intégral et bibtex
-
2010
- ref_biblio
- Alexis Bavencoffe, Dimitra Gkika, Artem Kondratskyi, Benjamin Beck, Anne-Sophie Borowiec, et al.. The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway. Journal of Biological Chemistry, 2010, 285 (13), pp.9410-9419. ⟨10.1074/jbc.M109.069377⟩. ⟨hal-03060332⟩
- Accès au texte intégral et bibtex
-
2009
- ref_biblio
- Jacques Noël, Katharina Zimmermann, Jérôme Busserolles, Emanuel Deval, Abdelkrim Alloui, et al.. The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.. EMBO Journal, 2009, 28 (9), pp.1308-18. ⟨10.1038/emboj.2009.57⟩. ⟨hal-00418382⟩
- Accès au bibtex
-
2006
- ref_biblio
- Jérôme Busserolles, Elyette Gueux, Bozena Balasinska, Yannick Piriou, Edmond Rock, et al.. In vivo antioxidant activity of procyanidin-Rich extracts from grape seed and pine (Pinus maritima) bark in rats. International Journal for Vitamin and Nutrition Research, 2006, 76 (1), pp.22-27. ⟨10.1024/0300-9831.76.1.22⟩. ⟨hal-02667841⟩
- Accès au bibtex
-